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Abstract

Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging.

M A van Buchem, J K Udupa, J C McGowan, Y Miki, F H Heyning, M P Boncoeur-Martel, D L Kolson, M Polansky and R I Grossman
American Journal of Neuroradiology August 1997, 18 (7) 1287-1290;
M A van Buchem
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J K Udupa
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J C McGowan
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Y Miki
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F H Heyning
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M P Boncoeur-Martel
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D L Kolson
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M Polansky
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R I Grossman
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Abstract

We report a semiautomated postprocessing method based on magnetization transfer MR imaging that can quantify the extent of global disease in patients with multiple sclerosis. The technique combines segmentation and quantitative analysis of imaging data reflecting the structural integrity of white matter. Applications of this technique may include assessment of disease progress and of the efficacy of experimental therapeutic intervention. The height of the histogram peak corresponding to white matter was found to be lowered in patients with multiple sclerosis and the overall distribution of magnetization transfer ratios was shifted to lower values.

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American Journal of Neuroradiology
Vol. 18, Issue 7
1 Aug 1997
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Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging.
M A van Buchem, J K Udupa, J C McGowan, Y Miki, F H Heyning, M P Boncoeur-Martel, D L Kolson, M Polansky, R I Grossman
American Journal of Neuroradiology Aug 1997, 18 (7) 1287-1290;

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Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging.
M A van Buchem, J K Udupa, J C McGowan, Y Miki, F H Heyning, M P Boncoeur-Martel, D L Kolson, M Polansky, R I Grossman
American Journal of Neuroradiology Aug 1997, 18 (7) 1287-1290;
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  • The effect of gadolinium-enhancing lesions on whole brain atrophy in relapsing-remitting MS
  • BRAIN IMAGING
  • Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis
  • Characterization of White Matter Lesions in Multiple Sclerosis and Traumatic Brain Injury as Revealed by Magnetization Transfer Contour Plots
  • Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular
  • Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple
  • Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application
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