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The New World Health Organization Classification of Central Nervous System Tumors: What Can the Neuroradiologist Really Say?

A.G. Osborn, K.L. Salzman, M.M. Thurnher, J.H. Rees and M. Castillo
American Journal of Neuroradiology May 2012, 33 (5) 795-802; DOI: https://doi.org/10.3174/ajnr.A2583
A.G. Osborn
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K.L. Salzman
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M.M. Thurnher
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J.H. Rees
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M. Castillo
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Abstract

SUMMARY: The WHO Classification of Tumors of the Central Nervous System has become the worldwide standard for classifying and grading brain neoplasms. The most recent edition (WHO 2007) introduced a number of significant changes that include both additions and redefinitions or clarifications of existing entities. Eight new neoplasms and 4 new variants were introduced. This article reviews these entities, summarizing both their histology and imaging appearance. Now with more than 3 years of clinical experience following publication of the newest revision, we also ask, “What can the neuroradiologist really say?” Are there imaging findings that could suggest the preoperative diagnosis of a new tumor entity or variant?

ABBREVIATIONS:

aCPP
atypical choriod plexus papilloma
CNS
central nervous system
CPP
choriod plexus papilloma
CPCa
choriod plexus carcinoma
DNET
dysembryoplastic neuroepithelial tumor
EVNCT
extraventricular neurocytoma
MB
medulloblastoma
MBEN
medulloblastoma with extensive nodularity
PA
pilocytic astrocytoma
PGNT
papillary glioneuronal tumor
PMA
pilomyxoid astrocytoma
PPTID
pineal parenchymal tumor of intermediate differentiation
PTPR
papillary tumor of the pineal region
RGNT
rosette-forming glioneuronal tumor
SCO
spindle cell oncocytoma
T1C+
post-contrast T1-weighted
T1WI
T1-weighted imaging
T2WI
T2-weighted imaging
WHO
World Health Organization
  • © 2012 by American Journal of Neuroradiology

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American Journal of Neuroradiology: 33 (5)
American Journal of Neuroradiology
Vol. 33, Issue 5
1 May 2012
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A.G. Osborn, K.L. Salzman, M.M. Thurnher, J.H. Rees, M. Castillo
The New World Health Organization Classification of Central Nervous System Tumors: What Can the Neuroradiologist Really Say?
American Journal of Neuroradiology May 2012, 33 (5) 795-802; DOI: 10.3174/ajnr.A2583

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The New World Health Organization Classification of Central Nervous System Tumors: What Can the Neuroradiologist Really Say?
A.G. Osborn, K.L. Salzman, M.M. Thurnher, J.H. Rees, M. Castillo
American Journal of Neuroradiology May 2012, 33 (5) 795-802; DOI: 10.3174/ajnr.A2583
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