January 10, 2011
Patient with a history of chronic myeloid leukemia presenting with decreased visual acuity in the left eye.
Granulocytic Sarcoma (Chloroma/Extramedullary Myeloblastoma)
- Granulocytic sarcoma is a solid tumor composed of primitive precursors of the granulocytic series of white blood cells.
- The presence of this tumor suggests the occurrence of acute myelogenous leukemia or heralds the onset of the blastic phase of chronic myelogenous leukemia.
- Tumors can involve any part of the body but preferentially involve the orbits and subcutaneous tissues.
- Key Diagnostic Features: MR is the imaging modality of choice. These tumors appear isointense on T1WI, hypointense on T2WI, and demonstrate near homogenous intense contrast enhancement. Restricted diffusion is noted on DWI due to a high nuclear to cytoplasmic ratio.
- DDx: Lymphoma, metastasis, meningioma, hemangiopericytoma
