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Review ArticleREVIEW ARTICLE
Open Access

Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist

J.D. Oldan, V.L. Jewells, B. Pieper and T.Z. Wong
American Journal of Neuroradiology April 2021, DOI: https://doi.org/10.3174/ajnr.A7079
J.D. Oldan
aFrom the Department of Radiology (J.D.O., V.L.J), University of North Carolina, Chapel Hill, North Carolina
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V.L. Jewells
aFrom the Department of Radiology (J.D.O., V.L.J), University of North Carolina, Chapel Hill, North Carolina
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B. Pieper
bDepartment of Radiology (B.P.), Richard L. Roudebush VA Medical Center, Indianapolis, Indiana
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T.Z. Wong
cDepartment of Radiology (T.Z.W.), Duke University Hospital, Durham, North Carolina
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Abstract

SUMMARY: This article will familiarize neuroradiologists with the pathophysiology, clinical findings, and standard MR imaging and PET imaging features of multiple forms of dementia as well as new emerging techniques. Cases were compiled from multiple institutions with the goal of improved diagnostic accuracy and improved patient care as well as information about biomarkers on the horizon. Dementia topics addressed include the following: Alzheimer disease, frontotemporal dementia, cerebral amyloid angiopathy, Lewy body dementia, Parkinson disease and Parkinson disease variants, amyotrophic lateral sclerosis, multisystem atrophy, Huntington disease vascular dementia, and Creutzfeldt-Jakob disease.

ABBREVIATIONS:

AD
Alzheimer disease
CAA
cerebral amyloid angiopathy
CBD
corticobasilar degeneration
FTD
frontotemporal dementia
LBD
Lewy body dementia
MCI
mild cognitive impairment
MH
microhemorrhages
MSA
multisystem atrophy
PD
Parkinson disease
PSP
progressive supranuclear palsy
rsfMRI
resting-state fMRI

Footnotes

  • Paper previously presented, in part, at: Annual AOCR Convention 2019, Merging Mind and Muscle, April 8-12, 2019, San Antonio, Texas.

  • Disclosures: Valerie L. Jewells—UNRELATED: Payment for Development of Educational Presentations: American Osteopathic College of Radiology, Comments: I gave a lecture on this topic and received a $250 stipend. Terence Z. Wong—RELATED: Consulting Fee or Honorarium: Lilly USA, LLC, Comments: In 2012, I served as a consultant to develop educational training materials for the interpretation of florbetapir scans (amyloid imaging for dementia).

  • © 2021 by American Journal of Neuroradiology

Indicates open access to non-subscribers at www.ajnr.org

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Cite this article
J.D. Oldan, V.L. Jewells, B. Pieper, T.Z. Wong
Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7079

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Complete Evaluation of Dementia: PET and MRI Correlation and Diagnosis for the Neuroradiologist
J.D. Oldan, V.L. Jewells, B. Pieper, T.Z. Wong
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7079
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