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Abstract

Localized cerebral proton MR spectroscopy in HIV infection and AIDS.

W K Chong, M Paley, I D Wilkinson, M A Hall-Craggs, B Sweeney, M J Harrison, R F Miller and B E Kendall
American Journal of Neuroradiology January 1994, 15 (1) 21-25;
W K Chong
MR Unit, Middlesex Hospital, London, England.
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M Paley
MR Unit, Middlesex Hospital, London, England.
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I D Wilkinson
MR Unit, Middlesex Hospital, London, England.
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M A Hall-Craggs
MR Unit, Middlesex Hospital, London, England.
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B Sweeney
MR Unit, Middlesex Hospital, London, England.
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M J Harrison
MR Unit, Middlesex Hospital, London, England.
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R F Miller
MR Unit, Middlesex Hospital, London, England.
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B E Kendall
MR Unit, Middlesex Hospital, London, England.
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Abstract

PURPOSE To document differences in the cerebral proton MR spectra of patients with early and late stages of human immunodeficiency virus (HIV) infection.

METHOD We studied the relative N-acetyl-aspartate (NAA) levels by localized proton spectroscopy of the parietooccipital region of the brain in 43 HIV-seropositive patients, including 26 with an acquired immunodeficiency syndrome (AIDS)-defining diagnosis, and in eight control subjects.

RESULTS Reduced relative NAA levels were shown in those HIV-1-seropositive patients: 1) with AIDS against HIV-1-seropositive patients without AIDS (P < .04); 2) with HIV-1-associated cognitive/motor complex against neurologically healthy patients (P < .007); 3) with encephalopathic changes on MR against those with normal imaging (P < .001); and 4) on follow-up against their results on initial study (P < .03).

CONCLUSIONS By clinical (Centers for Disease Control classification) and radiologic (MR evidence of white-matter disease) criteria indicating late-stage HIV infection, reduced relative levels of NAA have been demonstrated. Spectroscopic abnormalities can be quantitatively tracked with time. This paper demonstrates the clinical use of detecting NAA as a putative in vivo measure of the neuronal loss that has been demonstrated in postmortem studies of patients with AIDS. This neuronal loss, which is believed to underlie the HIV-1-associated cognitive/motor complex, is thought to be attributable directly or indirectly to the presence of HIV in the brain. Proton spectroscopy may serve as a quantitative noninvasive indicator of this aspect of cerebral involvement in HIV disease.

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American Journal of Neuroradiology
Vol. 15, Issue 1
1 Jan 1994
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Cite this article
W K Chong, M Paley, I D Wilkinson, M A Hall-Craggs, B Sweeney, M J Harrison, R F Miller, B E Kendall
Localized cerebral proton MR spectroscopy in HIV infection and AIDS.
American Journal of Neuroradiology Jan 1994, 15 (1) 21-25;

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Localized cerebral proton MR spectroscopy in HIV infection and AIDS.
W K Chong, M Paley, I D Wilkinson, M A Hall-Craggs, B Sweeney, M J Harrison, R F Miller, B E Kendall
American Journal of Neuroradiology Jan 1994, 15 (1) 21-25;
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  • Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV
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