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Abstract

Diagnostic applications of simultaneously acquired dual-isotope single-photon emission CT scans.

D Mathews, B S Walker, B C Allen, H Batjer and P D Purdy
American Journal of Neuroradiology January 1994, 15 (1) 63-71;
D Mathews
Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9071.
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B S Walker
Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9071.
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B C Allen
Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9071.
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H Batjer
Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9071.
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P D Purdy
Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9071.
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Abstract

PURPOSE To report the development and validation of a technique of dual tracer single-photon emission CT brain imaging using technetium-99m hexamethylpropyleneamine oxime and iodine-123 iodoamphetamine agents and the application of this technique in patients with a variety of diagnoses.

METHODS Contamination between the two isotopes' energy windows was calculated by opening both energy windows while scanning a group of patients using a single isotope. To compare uniformity of I-123 down-scatter, Tc-99m studies were performed both before and after the administration of I-123 in five of 24 dual studies. The 24 patients studied with the dual-isotope technique were evaluated during acetazolamide testing, trial balloon occlusion, or embolization of an arteriovenous malformation.

RESULTS In a dual acquisition, average count contamination of an I-123 study by Tc-99m was less than 1% of the total I-123 counts, and contamination of a Tc-99m study by I-123 was approximately 12% of the total Tc-99m counts. Tc-99m studies performed both before and after the administration of I-123 demonstrated that contaminating counts do not adversely affect scan interpretation. Dual-tracer scans were completed in all 24 patients, 10 of whom showed changes after intervention.

CONCLUSIONS Dual-tracer single-photon emission CT brain scans of adequate diagnostic quality are possible using Tc-99m and I-123.

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American Journal of Neuroradiology
Vol. 15, Issue 1
1 Jan 1994
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Cite this article
D Mathews, B S Walker, B C Allen, H Batjer, P D Purdy
Diagnostic applications of simultaneously acquired dual-isotope single-photon emission CT scans.
American Journal of Neuroradiology Jan 1994, 15 (1) 63-71;

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Diagnostic applications of simultaneously acquired dual-isotope single-photon emission CT scans.
D Mathews, B S Walker, B C Allen, H Batjer, P D Purdy
American Journal of Neuroradiology Jan 1994, 15 (1) 63-71;
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