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Research ArticleBRAIN

Adult-Onset Neurologic Dysfunction Associated with Cortical Malformations

Woo Ho Cho, David Seidenwurm and A. James Barkovich
American Journal of Neuroradiology June 1999, 20 (6) 1037-1043;
Woo Ho Cho
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David Seidenwurm
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A. James Barkovich
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    fig 1.

    Patient 3. Diffuse subependymal heterotopia.

    A, Sagittal spin-echo (550/15 [TR/TE]) image shows multiple ovoid subependymal nodules isointense to cortical gray matter, protruding into the lateral ventricle.

    B, Axial spin-echo (2500/80) image shows that diffuse heterotopia, lining the lateral walls of the lateral ventricles, remain isointense to gray matter.

    C, Midline sagittal spin-echo (550/15) image shows the diffusely thin body of the corpus callosum and a large posterior fossa cyst.

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    fig 2.

    Patient 7. Heterotopia involving the frontal horn. Axial spin-echo (2500/80) image shows subependymal heterotopia associated with the dilated left frontal horn.fig 3. Patient 1. Contiguous subependymal heterotopia.

    A, Axial spin-echo (2500/80) image shows multiple contiguous nodules lining the occipital homs and trigones.

    B, Sagittal fast spin-echo (3500/102) image reveals the thin splenium.

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    fig 4.

    Single heterotopion. Axial spin-echo (2500/80) (A) and coronal 3D FT gradient-echo (35/7 [𝛉 = 35°]) (B) images show that the single heterotopion is associated with deep infolding of the adjacent cortex (arrows).fig 5. Patient 15. Closed-lip schizencephaly. Axial spin-echo (2500/30) image shows small closed-lip schizencephaly involving the left central fissure and decreased white matter volume of the ipsilateral hemisphere

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    TABLE 1:

    Clinical findings in 14 patients with SEH (patients 1–12) or schizencephaly (patients 13–14)

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    TABLE 2:

    Imaging findings in 12 patients with SEH

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American Journal of Neuroradiology
Vol. 20, Issue 6
1 Jun 1999
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Cite this article
Woo Ho Cho, David Seidenwurm, A. James Barkovich
Adult-Onset Neurologic Dysfunction Associated with Cortical Malformations
American Journal of Neuroradiology Jun 1999, 20 (6) 1037-1043;

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Adult-Onset Neurologic Dysfunction Associated with Cortical Malformations
Woo Ho Cho, David Seidenwurm, A. James Barkovich
American Journal of Neuroradiology Jun 1999, 20 (6) 1037-1043;
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