Research ArticleBRAIN
Inflammatory CNS Demyelination: Histopathologic Correlation with In Vivo Quantitative Proton MR Spectroscopy
Andreas Bitsch, Harald Bruhn, Vassilios Vougioukas, Argyris Stringaris, Hans Lassmann, Jens Frahm and Wolfgang Brück
American Journal of Neuroradiology October 1999, 20 (9) 1619-1627;
Andreas Bitsch
Harald Bruhn
Vassilios Vougioukas
Argyris Stringaris
Hans Lassmann
Jens Frahm

References
- ↵Lassmann H. Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Berlin, Heidelberg: Springer-Verlag; 1983
- Prineas J. W. The neuropathology of multiple sclerosis. In: Koetsier, J. C. Demyelinating Diseases. Amsterdam: Elsevier Science Publishers; 1985;8:213-257
- ↵Lucchinetti CF, Brück W, Rodriguez M, Lassmann H. Distinct patterns of Multiple Sclerosis pathology indicates heterogeneity in pathogenesis. Brain Pathol 1996;6:259-274
- ↵McDonald WI, Miller DH, Barnes D. The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 1992;18:319-334
- ↵Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 1998;121:3-24
- ↵Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997;42:783-793
- ↵Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990;14:154-159
- ↵Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118:1583-1592
- ↵De Stefano N, Matthews PM, Antel JP, Preul M, Francis G, Arnold DL. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909
- Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Frahm J. Non-invasive assessment of brain lesions by fast scan MRI and localized proton spectroscopy. Neuroradiology 1991;33:S279-S281
- Bruhn H, Frahm J, Merboldt KD, et al. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992;32:140-150
- ↵Arnold DL, Matthews PM, Francis GS, O'Connor J, Antel JP. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992;31:235-241
- Koopmans RA, Li DKB, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products. Lancet 1993;341:631-632
- ↵Frahm J, Hanefeld F. Localized proton magnetic resonance spectroscopy of brain disorders in childhood. In: Bachelard, H. S. Magnetic Resonance Spectroscopy and Imaging in Neurochemistry New York: Plenum Press 1997;12:329-402
- Kim MO, Lee SA, Choi CG, Huh JR, Lee MC. Balo's concentric sclerosis: a clinical case study of brain MRI, biopsy, and proton magnetic resonance spectroscopic findings. J Neurol Neurosurg Psych 1997;62:655-658
- ↵Silver NC, Barker RA, MacManus DG, et al. Proton magnetic resonance spectroscopy in a pathologically confirmed acute demyelinating lesion. J Neurol 1997;244:204-207
- ↵Davies SEC, Newcombe J, Williams SR, McDonald WI, Clark JB. High resolution proton NMR spectroscopy of multiple sclerosis lesions. J Neurochem 1995;64:742-748
- ↵Poser S, Lüer W, Bruhn H, Frahm J, Brück Y, Felgenhauer K. Acute demyelinating disease. Classification and non-invasive diagnosis. Acta Neurol Scand 1992;86:579-585
- ↵Brück W, Porada P, Poser S, et al. Monocyte/macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 1995;38:788-796
- ↵Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231
- Brück W, Schmied M, Suchanek G, et al. Oligodendrocytes in the early course of multiple sclerosis. Ann Neurol 1994;35:65-73
- ↵Colman DR, Kreibich G, Frey AB, Sabatini DD. Synthesis and incorporation of myelin polypeptides into CNS myelin. J Cell Biol 1982;95:598-608
- ↵Breitschopf H, Suchanek G, Gould RM, Colman DR, Lassmann H. In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol 1992;84:581-587
- ↵Mews I, Bergmann M, Bunkowski S, Gullotta F, Brück W. Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions. Multiple Sclerosis 1998;4:55-62
- ↵Frahm J, Michaelis T, Merboldt KD, Bruhn H, Gyngell ML, Hänicke W. Improvements in localized 1H-NMR spectroscopy of human brain. Water suppression, short echo times, and 1 mL resolution. J Magn Reson 1990;1990:464-473
- ↵Michaelis T, Merboldt K-D, Bruhn H, Hänicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219-227
- Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679
- ↵Pouwels PJW, Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med 1998;39:53-60
- ↵Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-399
- Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. New Engl J Med 1998;338:278-285
- De Stefano N, Matthews PM, Narayanan S, Francis GS, Antel JP, Arnold DL. Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient. Neurology 1997;49:1138-1141
- Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58
- ↵Urenjak J, Williams SR, Gadian DG, Noble M. Proton magnetic resonance spectroscopy unambigously identifies different neural cell types. J Neurosci 1993;13:981-989
- Bruhn H, Frahm J, Gyngell ML, et al. Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology 1989;172:541-548
- ↵
- ↵Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Sauter R. Localized proton NMR spectroscopy in different regions of the human brain in vivo: relaxation times and concentrations of cerebral metabolites. Magn Reson Med 1989;11:47-63
- Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis. Neurology 1991;41:1251-1256
- ↵Brenner RE, Munro PMG, Williams SCR, et al. The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio. Magn Reson Med 1993;29:737-745
- ↵Husted CA, Goodin DS, Hugg JW, et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol 1994;36:157-165
- Matthews PM, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996;119:715-722
- ↵Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993;15:189-198
- Landtblom A-M, Sjöqvist L, Söderfeldt B, Nyland H, Thuomas K-A. Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis—ringlike appearances in acute plaques. Acta radiol 1996;37:278-287
- Pouwels PJW, Hanefeld F, Frahm J. Proton MRS in Pelizaeus-Merzbacher disease. Neuropediatrics 1997;23:355-356
- Pan WP, Hetherington HP, Vaughan JT, Mitchell G, Pohost GM, Whitaker JN. Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T. Magn Reson Med 1996;36:72-77
- ↵Lopez-Villegas D, Lenkinski RE, Wehrli SL, Ho W-Z, Douglas SD. Lactate production by human monocytes/macrophages determined by proton MR spectroscopy. Magn Reson Med 1995;34:32-38
In this issue
Advertisement
Andreas Bitsch, Harald Bruhn, Vassilios Vougioukas, Argyris Stringaris, Hans Lassmann, Jens Frahm, Wolfgang Brück
Inflammatory CNS Demyelination: Histopathologic Correlation with In Vivo Quantitative Proton MR Spectroscopy
American Journal of Neuroradiology Oct 1999, 20 (9) 1619-1627;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
- In vivo assessment of astrocyte reactivity in patients with progressive supranuclear palsy
- Linking cortical lesions to metabolic changes in multiple sclerosis using 7T proton MR spectroscopy
- The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditions
- Alterations of Brain Metabolites in Adults With HIV: A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies
- BRAIN MR SPECTROSCOPIC FINDINGS IN THREE CONSECUTIVE COVID-19 PATIENTS: PRELIMINARY OBSERVATIONS
- Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations
- NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study
- Regional Myo-Inositol, Creatine, and Choline Levels Are Higher at Older Age and Scale Negatively with Visuospatial Working Memory: A Cross-Sectional Proton MR Spectroscopy Study at 7 Tesla on Normal Cognitive Ageing
- Magnetic Resonance Imaging in Multiple Sclerosis
- Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels
- Early Alzheimer's Disease Neuropathology Detected by Proton MR Spectroscopy
- Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions
- Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS
- Metabolic profile of PML lesions in patients with and without IRIS: An observational study
- Correlating Quantitative MR Imaging with Histopathology in X-Linked Adrenoleukodystrophy
- Intracranial dural arteriovenous fistula presenting as an enhancing lesion of the medulla
- MRS in presymptomatic MAPT mutation carriers: A potential biomarker for tau-mediated pathology
- Diffuse White Matter Damage Is Absent in Neuromyelitis Optica
- MR spectroscopy indicates diffuse multiple sclerosis activity during remission
- Role of MRI in the differentiation of ADEM from MS in children
- Proton MR Spectroscopy Improves Discrimination between Tumor and Pseudotumoral Lesion in Solid Brain Masses
- 1H Magnetic resonance spectroscopy in dementia
- Guidelines for using proton MR spectroscopy in multicenter clinical MS studies
- Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study
- 1H MR spectroscopy in common dementias
- Five new cases of a recently described leukoencephalopathy with high brain lactate
- Inflammatory Demyelinating Disease Mimicking Malignant Glioma
- Brain N-acetylaspartate is elevated in Pelizaeus-Merzbacher disease with PLP1 duplication
- Magnetic resonance spectroscopy in AD
- Altered white and gray matter metabolism in CADASIL: A proton MR spectroscopy and 1H-MRSI study
- The Choline/Creatine Ratio in Five Benign Neoplasms: Comparison with Squamous Cell Carcinoma by Use of in Vitro MR Spectroscopy
- Serial Proton MR Spectroscopy of Contrast-enhancing Multiple Sclerosis Plaques: Absolute Metabolic Values over 2 Years during a Clinical Pharmacological Study
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement