Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia

fig. 2. A–F, T2-weighted images (A and E) and ADC maps (B, C, D, F) of a representative rat (group C-2) that showed the biphasic ADC reduction pattern. T2-weighted images show no abnormal signal intensity before the hypoxic/ischemic insult (A), during the insult, or 60 minutes after resuscitation; they do show high signal intensity in the ipsilateral parietal cortex 48 hours after the insult (E). ADC maps show no ADC change before the hypoxic/ischemic insult (B), acute ADC reduction in the ipsilateral parietal cortex during the insult (C), ADC recovery 60 minutes after resuscitation (D), and secondary ADC reduction in the ipsilateral parietal cortex 48 hours after the insult (F)

fig. 3. A–H, T2-weighted images (A–D) and ADC maps (E–H) of a representative rat (group C-3) that showed the persistent ADC reduction pattern.

A–D, T2-weighted images show no abnormal signal intensity before the hypoxic/ischemic insult (A), during the insult (B), or 60 minutes after resuscitation (C); they do show high signal intensity in the ipsilateral parietal cortex 6 hours after the insult (D).

E–H, ADC maps show no ADC change before the hypoxic/ischemic insult (E), acute ADC reduction in the ipsilateral parietal cortex during the insult (F), and sustained ADC decrease 60 minutes after resuscitation (G) and 6 hours after the insult (H).