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Research ArticleBRAIN

MR Imaging and Proton MR Spectroscopy in Adult Krabbe Disease

Laura Farina, Alberto Bizzi, Gaetano Finocchiaro, Davide Pareyson, Angelo Sghirlanzoni, Barbara Bertagnolio, Mario and Savoiardo, and SakkuBai Naidu, Bhim S. Singhal and David A. Wenger
American Journal of Neuroradiology September 2000, 21 (8) 1478-1482;
Laura Farina
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Alberto Bizzi
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Gaetano Finocchiaro
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Davide Pareyson
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Angelo Sghirlanzoni
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Barbara Bertagnolio
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Mario and Savoiardo
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and SakkuBai Naidu
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Bhim S. Singhal
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David A. Wenger
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    fig 1.

    Case 1.

    A, Axial FLAIR image (9264/150/2; TI = 2200) shows increased signal intensity of the white matter of the precentral gyri, which are atrophic (arrowhead).

    B, Coronal FLAIR image (9264/150/2; TI = 2200) shows the hyperintensity limited to the upper part of the motor cortex (arrows) and extending across the corpus callosum (arrowheads).

    C, Midline sagittal turbo spin-echo T2-weighted image (5422/110/2) shows thin, slightly hyperintense isthmus of the corpus callosum (arrow).

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    fig 2.

    Case 2. Selected proton MR spectra (PRESS, 1500/136/1; nominal voxel size, 2 cm3) from the voxels indicated on the scout spin-echo T2-weighted MR image (2000/90/1; thickness, 10 mm) show moderate choline elevation (3.2 ppm), mild NAA loss (2.02 ppm), normal creatine peak (3.0 ppm), and an abnormally elevated peak at 3.6 ppm (myo-inositol) in the centrum semiovale. Spectra from the parasagittal cortical gray matter show only mild NAA loss. Similar proton MR spectroscopic findings in the centrum semiovale were found in case 1

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    fig 3.

    Case 4.

    A and B, Coronal T2-weighted images (3648/99/2) of adjacent sections, A posterior to B, show nearly symmetrical involvement of the corticospinal tract from the cortex (A) to the brain stem (B) (asterisks).

    C, Axial T2-weighted image (2100/90/2) at pontine level shows symmetrical pyramidal involvement (arrowhead).

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    Metabolites ratios from proton MR spectroscopy

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American Journal of Neuroradiology
Vol. 21, Issue 8
1 Sep 2000
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Cite this article
Laura Farina, Alberto Bizzi, Gaetano Finocchiaro, Davide Pareyson, Angelo Sghirlanzoni, Barbara Bertagnolio, Mario and Savoiardo, and SakkuBai Naidu, Bhim S. Singhal, David A. Wenger
MR Imaging and Proton MR Spectroscopy in Adult Krabbe Disease
American Journal of Neuroradiology Sep 2000, 21 (8) 1478-1482;

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MR Imaging and Proton MR Spectroscopy in Adult Krabbe Disease
Laura Farina, Alberto Bizzi, Gaetano Finocchiaro, Davide Pareyson, Angelo Sghirlanzoni, Barbara Bertagnolio, Mario and Savoiardo, and SakkuBai Naidu, Bhim S. Singhal, David A. Wenger
American Journal of Neuroradiology Sep 2000, 21 (8) 1478-1482;
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