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Research ArticlePEDIATRICS

Neonatal Hypoxic-ischemic Encephalopathy: Detection with Diffusion-weighted MR Imaging

Kirsten P. N. Forbes, James G. Pipe and Roger Bird
American Journal of Neuroradiology September 2000, 21 (8) 1490-1496;
Kirsten P. N. Forbes
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James G. Pipe
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Roger Bird
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    fig 1.

    Subject 4: watershed ischemia.

    A, T1-weighted image shows hypointensity bilaterally in the anterior and posterior watershed areas.

    B, T2-weighted image shows hyperintensity in the same areas, suggesting edema.

    C, Anisotropic diffusion-weighted image (z gradient) shows corresponding signal hyperintensity.

    D, Isotropic ADC map confirms a decrease in water diffusion with hypointensity in all watershed regions, most prominently seen in left posterior watershed area.

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    fig 2.

    Subject 10: deep gray matter ischemia.

    A and B, T1-weighted (A) and T2-weighted (B) images show hyperintensity in the thalami and lentiform nuclei.

    C and D, Anisotropic diffusion-weighted image (z gradient) (C) and isotropic ADC map (D) confirm normal water diffusion.

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    fig 3.

    Cortical injuries: correlation between image timing and ADC changes. The age of each subject with cortical ischemic damage is shown. ADC changes within the ischemic region were calculated using normal published values (16), with error bars shown (SD). All subjects except case 12 (day 11) had a significant decrease in ADC values

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    fig 4.

    Thalamic injuries: correlation between image timing and ADC changes. The age of each subject with thalamic ischemic damage is shown. Four imaging studies show a significant decrease in ADC: subjects 5 (day 2); 12 (days 4 and 11), and 13 (day 9)

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    Clinical findings

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    TABLE 2:

    Basal ganglia/watershed scoring system

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    TABLE 3:

    Imaging findings according to site of ischemic damage

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American Journal of Neuroradiology
Vol. 21, Issue 8
1 Sep 2000
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Cite this article
Kirsten P. N. Forbes, James G. Pipe, Roger Bird
Neonatal Hypoxic-ischemic Encephalopathy: Detection with Diffusion-weighted MR Imaging
American Journal of Neuroradiology Sep 2000, 21 (8) 1490-1496;

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Neonatal Hypoxic-ischemic Encephalopathy: Detection with Diffusion-weighted MR Imaging
Kirsten P. N. Forbes, James G. Pipe, Roger Bird
American Journal of Neuroradiology Sep 2000, 21 (8) 1490-1496;
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  • Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy
  • An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
  • A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns
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