Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleLetter

Reply:

Suresh K. Mukherji
American Journal of Neuroradiology November 2001, 22 (10) 1983-1984;
Suresh K. Mukherji
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
Loading

We thank Drs. O'Tuama and Poussaint for their interest in our work (1). Our study group consisted of patients with recurrent tumors and not primary neoplasms. Thus, we did not have the ability to investigate the prognostic capability of thallium-201 before treatment. It would have been difficult to draw any such conclusions from our patient population because we evaluated previously treated patients with recurrent disease, and the effect of thallium uptake after various forms of treatment has not been sufficiently investigated.

Drs. O'Tuama and Poussaint raise a potentially important use of thallium with respect to predicting treatment response and potentially stratifying treatment regimens on the basis of objective quantitative criteria. I would call their attention to the work of Nagamachi et al (2, 3). This group semiquantitatively measured 201Tl to predict the response of squamous cell carcinoma of the head and neck to radiation therapy. The measurements consisted of a 201Tl retention index; the details of this technique are described in their articles. Nagamachi et al (3) found that the pretreatment retention index was predictive of response to radiation therapy. A high retention index was predictive of a reduction in size of 50% or more at the primary site (complete or partial response), whereas a low retention index was predictive of response of less than 50% (3). We recently evaluated the capability of combined imaging before and after the administration of 201Tl in predicting the response of squamous cell carcinoma of the head and neck to nonsurgical organ preservation therapy (4). Our preliminary results showed that persistence of activity in the primary site 6 wk after the completion of therapy was indicative of persistent tumor, whereas loss of uptake was indicative of local control (4). We did not, however, quantify the pretreatment thallium uptake of the tumors in this report (4). This is something that we certainly can consider in future studies to shed more light on the insightful inquiry that Drs. O'Tuama and Poussaint presented.

References

  1. ↵
    Mukherji SK, Gapany M, Phillips D, et al. Thallium-201 single-photon emission CT versus CT for the detection of recurrent squamous cell carcinoma of the head and neck. AJNR Am J Neuroradiol 1999;20:1215-1220
    Abstract/FREE Full Text
  2. ↵
    Nagamachi S, Hoshi H, Jinnouchi S, et al. 201Tl SPECT for evaluating head and neck cancer. Ann Nucl Med 1996;10:105-111
    PubMed
  3. ↵
    Nagamachi S, Jinnouchi S, Flores LG, et al. The use of 201T1 SPET to predict the response to radiotherapy in patients with head and neck cancer. Nucl Med Commun 1996;17:935-942
    PubMed
  4. ↵
    Mukherji SK, Gapany M, Neelon B, McCartney W. Evaluation of 201T1 SPECT for predicting early treatment response in patients with squamous cell carcinoma of the extracranial head and neck treated with nonsurgical organ preservation therapy: initial results. J Comput Assist Tomogr 2000;24:146-151
    PubMed
  • Copyright © American Society of Neuroradiology
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 22 (10)
American Journal of Neuroradiology
Vol. 22, Issue 10
1 Nov 2001
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Reply:
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Reply:
Suresh K. Mukherji
American Journal of Neuroradiology Nov 2001, 22 (10) 1983-1984;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Reply:
Suresh K. Mukherji
American Journal of Neuroradiology Nov 2001, 22 (10) 1983-1984;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • References
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Fair Performance of CT in Diagnosing Unilateral Vocal Fold Paralysis
  • Reply:
  • Regarding “Altered Blood Flow in the Ophthalmic and Internal Carotid Arteries in Patients with Age-Related Macular Degeneration Measured Using Noncontrast MR Angiography at 7T”
Show more Letter

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire