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Research ArticlePEDIATRICS

Prospective Evaluation of the Brain in Asymptomatic Children with Neurofibromatosis Type 1: Relationship of Macrocephaly to T1 Relaxation Changes and Structural Brain Abnormalities

R. Grant Steen, June S. Taylor, James W. Langston, John O. Glass, Vickie R. Brewer, Wilburn E. Reddick, Roy Mages and Eniko K. Pivnick
American Journal of Neuroradiology May 2001, 22 (5) 810-817;
R. Grant Steen
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June S. Taylor
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James W. Langston
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John O. Glass
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Vickie R. Brewer
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Wilburn E. Reddick
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Roy Mages
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Eniko K. Pivnick
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    fig 1.

    A, T1-weighted sagittal midline image (266/6/3) in an 11-year old boy with NF-1 and macrocephaly shows where the measurements of midline structures were made (see Table 2). This boy had thickening of the corpus callosum and enlargement of the anteroposterior diameter of the pons and medulla.

    B, T2-weighted transverse image (3500/93/1) in an 8-year old girl shows bilateral lesions in the globus pallidus and tectum

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    fig 2.

    Scatterplot of quantitative tissue T1 in the nucleus pulvinarus versus FSIQ in children with NF-1 (r = .58; P = .012 by ANOVA)

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    Table 1:

    Summary of WISC-III data in asymptomatic NF-1 subjects

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    Table 2:

    Summary of findings from conventional MR imaging

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    Table 3:

    Mean T1 values in healthy controls and in all NF-1 subjects combined, or in NF-1 subjects with normocephaly or macrocephaly

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    Table 4:

    Brain volume in asymptomatic NF-1 patients and controls

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American Journal of Neuroradiology
Vol. 22, Issue 5
1 May 2001
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Cite this article
R. Grant Steen, June S. Taylor, James W. Langston, John O. Glass, Vickie R. Brewer, Wilburn E. Reddick, Roy Mages, Eniko K. Pivnick
Prospective Evaluation of the Brain in Asymptomatic Children with Neurofibromatosis Type 1: Relationship of Macrocephaly to T1 Relaxation Changes and Structural Brain Abnormalities
American Journal of Neuroradiology May 2001, 22 (5) 810-817;

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Prospective Evaluation of the Brain in Asymptomatic Children with Neurofibromatosis Type 1: Relationship of Macrocephaly to T1 Relaxation Changes and Structural Brain Abnormalities
R. Grant Steen, June S. Taylor, James W. Langston, John O. Glass, Vickie R. Brewer, Wilburn E. Reddick, Roy Mages, Eniko K. Pivnick
American Journal of Neuroradiology May 2001, 22 (5) 810-817;
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Cited By...

  • Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1
  • White Matter is Increased in the Brains of Adults with Neurofibromatosis 1
  • Validating indicators of CNS disorders in a swine model of neurological disease
  • Neurofibromatosis Type 1: Modeling CNS Dysfunction
  • Brain structure and function in neurofibromatosis type 1: current concepts and future directions
  • T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning
  • Aberrant Growth and Differentiation of Oligodendrocyte Progenitors in Neurofibromatosis Type 1 Mutants
  • Megalencephaly in NF1: Predominantly white matter contribution and mitigation by ADHD
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