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OtherBRAIN

Emerging Patterns of Diffusion-Weighted MR Imaging in Creutzfeldt-Jakob Disease: Case Report and Review of the Literature

Yang Mao-Draayer, Steven P. Braff, Keith J. Nagle, William Pendlebury, Paul L. Penar and Robert E. Shapiro
American Journal of Neuroradiology April 2002, 23 (4) 550-556;
Yang Mao-Draayer
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Steven P. Braff
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Keith J. Nagle
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William Pendlebury
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Paul L. Penar
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Robert E. Shapiro
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Fig 1.

Serial MR images demonstrate the evolution of ribbon-like cortical signal intensity abnormalities. MR images are presented at each of three brain axial levels (1–3), at each of three time points from the onset of symptoms (left columns, 4 months; middle columns, 5.5 months; right columns, 6 months) for FLAIR (top row), DW imaging (middle row), and ADC (bottom row) studies. At 4 months from onset of symptoms, DW images demonstrate gyriform increased signal intensity predominantly in the right temporal cortex (DWI1D) with decreased ADC signal intensity consistent with restricted diffusion (ADC1G). At 5.5 months from onset, the hyperintense signals on DW images involve more cortical gyri, extending into the left temporoparietal cortex (DWI3E). At 6 months from onset, DW images (DWI1F, DWI2F, and DWI3F) show ribbon-like areas of hyperintensity involving the right temporoparietooccipital cortex, as well as the left frontotempoparietal cortex, extending into the parafalcine occipital region.

Images on this page were obtained at level 1.

(continued) Images on this page were obtained at level 2.

(continued) Images on this page were obtained at level 3.

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American Journal of Neuroradiology: 46 (5)
American Journal of Neuroradiology
Vol. 46, Issue 5
1 May 2025
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Cite this article
Yang Mao-Draayer, Steven P. Braff, Keith J. Nagle, William Pendlebury, Paul L. Penar, Robert E. Shapiro
Emerging Patterns of Diffusion-Weighted MR Imaging in Creutzfeldt-Jakob Disease: Case Report and Review of the Literature
American Journal of Neuroradiology Apr 2002, 23 (4) 550-556;

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Emerging Patterns of Diffusion-Weighted MR Imaging in Creutzfeldt-Jakob Disease: Case Report and Review of the Literature
Yang Mao-Draayer, Steven P. Braff, Keith J. Nagle, William Pendlebury, Paul L. Penar, Robert E. Shapiro
American Journal of Neuroradiology Apr 2002, 23 (4) 550-556;
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