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Research ArticleBRAIN

Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas?

Tufail F. Patankar, Hamied A. Haroon, Samantha J. Mills, Danielle Balériaux, David L. Buckley, Geoff J.M. Parker and Alan Jackson
American Journal of Neuroradiology November 2005, 26 (10) 2455-2465;
Tufail F. Patankar
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Hamied A. Haroon
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Samantha J. Mills
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Danielle Balériaux
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David L. Buckley
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Geoff J.M. Parker
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Alan Jackson
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References

  1. ↵
    Shin JH, Lee HK, Kwun BD, et al. Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. AJR Am J Roentgenol 2002;179:783–789
    CrossRefPubMed
  2. ↵
    Ludemann L, Grieger W, Wurm R, et al. Comparison of dynamic contrast-enhanced MRI with WHO tumor grading for gliomas. Eur Radiol 2001;11:1231–1241
    CrossRefPubMed
  3. ↵
    Law M, Yang S, Wang H, et al. Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 2003;24:1989–1998
    Abstract/FREE Full Text
  4. ↵
    Law M, Cha S, Knopp EA, et al. High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 2002;222:715–721
    PubMedWeb of Science
  5. ↵
    Knopp EA, Cha S, Johnson G, et al. Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 1999;211:791–798
    CrossRefPubMedWeb of Science
  6. ↵
    Fuss M, Wenz F, Essig M, et al. Tumor angiogenesis of low-grade astrocytomas measured by dynamic susceptibility contrast-enhanced MRI (DSC-MRI) is predictive of local tumor control after radiation therapy. Int J Radiat Oncol Biol Phys 2001;51:478–482
    CrossRefPubMed
  7. ↵
    Aronen HJ, Perkio J. Dynamic susceptibility contrast MRI of gliomas. Neuroimaging Clin N Am 2002;12:501–523
    CrossRefPubMed
  8. ↵
    Aronen HJ, Gazit IE, Louis DN, et al. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994;191:41–51
    PubMedWeb of Science
  9. Haroon HA, Buckley DL, Patankar TA, et al. A comparison of Ktrans measurements obtained with conventional and first pass pharmacokinetic models in human gliomas. J Magn Reson Imaging 2004;19:527–536
    CrossRefPubMed
  10. ↵
    Provenzale JM, Wang GR, Brenner T, et al. Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging. AJR Am J Roentgenol 2002;178:711–716
    CrossRefPubMedWeb of Science
  11. ↵
    Roberts HC, Roberts TP, Brasch RC, Dillon WP. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891–899
    Abstract/FREE Full Text
  12. ↵
    Sugahara T, Korogi Y, Kochi M, et al. Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. AJR Am J Roentgenol 1998;171:1479–1486
    CrossRefPubMedWeb of Science
  13. ↵
    Croteau D, Scarpace L, Hearshen D, et al. Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma. Neurosurgery 2001;49:823–829
    CrossRefPubMedWeb of Science
  14. ↵
    Wong ET, Jackson EF, Hess KR, et al. Correlation between dynamic MRI and outcome in patients with malignant gliomas. Neurology 1998;50:777–781
    Abstract/FREE Full Text
  15. Wong JC, Provenzale JM, Petrella JR. Perfusion MR imaging of brain neoplasms. AJR Am J Roentgenol 2000;174:1147–1157
    PubMed
  16. Cha S, Knopp EA, Johnson G, et al. Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology 2002;223:11–29
    CrossRefPubMedWeb of Science
  17. Lev MH, Rosen BR. Clinical applications of intracranial perfusion MR imaging. Neuroimaging Clin N Am 1999;9:309–331
    PubMedWeb of Science
  18. ↵
    Petrella JR, Provenzale JM. MR perfusion imaging of the brain: techniques and applications. AJR Am J Roentgenol 2000;175:207–219
    CrossRefPubMedWeb of Science
  19. ↵
    Aronen HJ, Pardo FS, Kennedy DN, et al. High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. Clin Cancer Res 2000;6:2189–2200
    Abstract/FREE Full Text
  20. ↵
    Lev MH, Ozsunar Y, Henson JW, et al. Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol 2004;25:214–221
    Abstract/FREE Full Text
  21. ↵
    Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)- weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223–232
    CrossRefPubMedWeb of Science
  22. ↵
    Li KL, Zhu XP, Checkley DR, et al. Simultaneous mapping of blood volume and endothelial permeability surface area product in gliomas using iterative analysis of first-pass dynamic contrast enhanced MRI data. Br J Radiol 2003;76:39–50
    Abstract/FREE Full Text
  23. ↵
    Zhu XP, Li KL, Kamaly-Asl ID, et al. Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J Magn Reson Imaging 2000;11:575–585
    CrossRefPubMedWeb of Science
  24. Johnson G, Wetzel SG, Cha S, et al. Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magn Reson Med 2004;51:961–968
    CrossRefPubMed
  25. ↵
    Weisskoff R, Boxermann J, Sorensen A, et al. Simultaneous blood volume and permeability mapping using a single Gd-based contrast injection. In: Proceedings of the International Society of Magnetic Resonance in Medicine. ISMRM: Berkeley, CA;1994 :279
  26. ↵
    Nasel C, Schindler E. [Xenon-CT and perfusion MRI in the diagnosis of cerebral gliomas]. Radiologe 1998;38:930–934
    PubMed
  27. ↵
    Nakagawa T, Tanaka R, Takeuchi S, Takeda N. Haemodynamic evaluation of cerebral gliomas using XeCT. Acta Neurochir (Wien) 1998;140:223–233; discussion 233–224
    CrossRefPubMedWeb of Science
  28. ↵
    van Dijke CF, Brasch RC, Roberts TP, et al. Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density. Radiology 1996;198:813–818
    PubMedWeb of Science
  29. Schwickert HC, Stiskal M, Roberts TP, et al. Contrast-enhanced MR imaging assessment of tumor capillary permeability: effect of irradiation on delivery of chemotherapy. Radiology 1996;198:893–898
    PubMed
  30. ↵
    Dvorak HF, Detmar M, Claffey KP, et al. Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int Arch Allergy Immunol 1995;107:233–235
    CrossRefPubMedWeb of Science
  31. ↵
    Law M, Yang S, Babb JS, et al. Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 2004;25:746–755
    Abstract/FREE Full Text
  32. ↵
    Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61:215–225; discussion 226–229
    PubMedWeb of Science
  33. ↵
    Li KL, Zhu XP, Waterton J, Jackson A. Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors. J Magn Reson Imaging 2000;12:347–357
    CrossRefPubMed
  34. ↵
    Tabachnick B, Fidell L. Using multivariate statistics. New York: Harper Collins;1996
  35. ↵
    Li KL, Jackson A. New hybrid technique for accurate and reproducible quantitation of dynamic contrast-enhanced MRI data. Magn Reson Med 2003;50:1286–1295
    CrossRefPubMed
  36. ↵
    Jackson A, Kassner A, Annesley-Williams D, et al. Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol 2002;23:7–14
    Abstract/FREE Full Text
  37. ↵
    Sugahara T, Korogi Y, Kochi M, et al. Perfusion-sensitive MR imaging of gliomas: comparison between gradient-echo and spin-echo echo-planar imaging techniques. AJNR Am J Neuroradiol 2001;22:1306–1315
    Abstract/FREE Full Text
  38. ↵
    Roberts TP. Physiologic measurements by contrast-enhanced MR imaging: expectations and limitations. J Magn Reson Imaging 1997;7:82–90
    PubMedWeb of Science
  39. ↵
    Jackson A, Jayson GC, Li KL, et al. Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma. Br J Radiol 2003;76:153–162
    Abstract/FREE Full Text
  40. ↵
    Ludemann L, Hamm B, Zimmer C. Pharmacokinetic analysis of glioma compartments with dynamic Gd-DTPA-enhanced magnetic resonance imaging. Magn Reson Imaging 2000;18:1201–1214
    CrossRefPubMed
  41. ↵
    Kassner A, Annesley DJ, Zhu XP, et al. Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. J Magn Reson Imaging 2000;11:103–113
    CrossRefPubMed
  42. ↵
    Jackson A, Kassner A, Zhu XP, Li KL. Reproducibility of T2* blood volume and vascular tortuosity maps in cerebral gliomas. J Magn Reson Imaging 2001;14:510–516
    CrossRefPubMed
  43. Bruening R, Kwong KK, Vevea MJ, et al. Echo-planar MR determination of relative cerebral blood volume in human brain tumors: T1 versus T2 weighting. AJNR Am J Neuroradiol 1996;17:831–840
    Abstract
  44. ↵
    Hacklander T, Hofer M, Reichenbach JR, et al. Cerebral blood volume maps with dynamic contrast-enhanced T1-weighted FLASH imaging: normal values and preliminary clinical results. J Comput Assist Tomogr 1996;20:532–539
    CrossRefPubMed
  45. ↵
    Jackson A, Haroon H, Zhu XP, et al. Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model. NMR Biomed 2002;15:164–173
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology
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Tufail F. Patankar, Hamied A. Haroon, Samantha J. Mills, Danielle Balériaux, David L. Buckley, Geoff J.M. Parker, Alan Jackson
Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas?
American Journal of Neuroradiology Nov 2005, 26 (10) 2455-2465;

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Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas?
Tufail F. Patankar, Hamied A. Haroon, Samantha J. Mills, Danielle Balériaux, David L. Buckley, Geoff J.M. Parker, Alan Jackson
American Journal of Neuroradiology Nov 2005, 26 (10) 2455-2465;
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  • Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer: Techniques and Clinical Applications
  • Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas
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