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Research ArticleBRAIN

Regional Cerebral Blood Flow After Acetazolamide Challenge in Patients with Dural Arteriovenous Fistula: Simple Way to Evaluate Intracranial Venous Hypertension

Jun Deguchi, Makoto Yamada, Hitoshi Kobata and Toshihiko Kuroiwa
American Journal of Neuroradiology May 2005, 26 (5) 1101-1106;
Jun Deguchi
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Makoto Yamada
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Hitoshi Kobata
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Toshihiko Kuroiwa
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    Fig 1.

    Case 21. Right lateral internal carotid angiograms show a Cognard type IV lesion in an asymptomatic patient.

    A, Preoperative image shows an anterior fossa DAVF with cortical venous reflux.

    B, Postoperative image shows disappearance of the DAVF and venous reflux.

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    Fig 2.

    Case 21. rCBF maps for a Cognard type IV lesion in an asymptomatic patient.

    A and B, Before surgery, resting rCBF in the right frontal region (white outline) is low (A), and the response of rCBF to the acetazolamide challenge is limited (B).

    C and D, At 6 months after surgery, resting rCBF (C) and the response of rCBF (D) to the acetazolamide challenge is increased.

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    Fig 3.

    Differences in rCBF between groups according to Cognard angiographic classification.

    A, Resting rCBF significantly differs between type I and types III and IV.

    B, After acetazolamide challenge, rCBF significantly differs, even between type I and type II.

    C, Increase in rCBF due to acetazolamide (ΔF, or acetazolamide value minus resting value) is significantly different between type I and the other types.

Tables

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    TABLE 1:

    Clinical summary of patients

    Patient/Age (y)/SexCognard ClassificationAffected SinusSymptomTreatment*
    DescriptionDue to Venous Hypertension?
    1/75/MIR sigmoidTinnitusNoTAE
    2/54/MISuperior sagittal sinusBulging scalp vesselsNoTAE
    3/78/FISuperior sagittal sinusAneurysm-like STA dilatationNoNone
    4/54/FIL cavernousNoneNANone
    5/58/MIR cavernousChemosis, diplopiaNoNone
    6/73/MIL cavernousDiplopiaNoNone
    7/75/FIL cavernousChemosisNoTVE
    8/62/MIIaL sigmoidTinnitusNoTAE, TVE
    9/75/MIIaR transverse sigmoidNoneNANone
    10/33/MIIbL transverse sigmoidHeadache, tinnitusYesTAE, TVE
    11/66/FIIbL cavernousDiplopia, disorientationYesTVE
    12/85/FIIbL cavernousChemosis, diplopiaNoTAE
    13/33/FIIa+bR transverse sigmoidHeadache, visual disturbanceYesTAE
    14/54/FIIa+bL transverse sigmoidDementiaYesTAE,TVE
    15/55/MIIIL transverse sigmoidHemorrhage, vertigo, convulsionYesTAE, TVE
    16/63/MIIIR transverse sigmoidHemorrhageYesTAE
    17/67/MIIIR transverse confluenceL lower quadrant homonymous anopsiaYesTAE, TVE
    18/72/FIIIL transverse confluenceDementiaYesTVE
    19/78/FIIIL transverseConvulsion, disturbed consciousnessYesTAE
    20/67/MIVL anterior fossaConvulsionYesSurgery
    21/74/MIVR anterior fossaNoneNASurgery
    • Note.—NA = Not applicable, STA = superficial temporal artery, TAE = transarterial embolization, TAV = transvenous embolization.

    • * All patients improved except for patients 3 and 12, whose condition was unchanged.

    • View popup
    TABLE 2:

    rCBF in patients with and those without symptoms caused by venous hypertension

    MeasureSymptomatic GroupAsymptomatic GroupP Value*
    Age (y)58.8 ± 15.369.4 ± 10.5.1118
    rCBF (mL/min/100g)
        Resting23.3 ± 5.133.2 ± 7.8.0092
        Acetazolamide27.1 ± 5.147.6 ± 10.9.0003
    ΔF†3.9 ± 2.714.4 ± 6.2.0002
    • * Mann-Whitney U test.

    • † Acetazolamide rCBF − resting rCBF.

    • View popup
    TABLE 3:

    Regional rCBF before and after treatment

    rCBF (ml/min/100g)Before Treatment6 Months After TreatmentP Value*
    Symptomatic patients (n = 10)
        Resting23.3 ± 5.126.8 ± 7.3.1849
        Acetazolamide27.1 ± 5.138.0 ± 12.4.0166
        ΔF†3.9 ± 2.711.2 ± 7.0.0367
    Asymptomatic patients (n = 4)
        Resting28.8 ± 8.230.1 ± 6.4>.05
        Acetazolamide38.4 ± 7.647.4 ± 8.6.0679
        ΔF†9.7 ± 2.617.2 ± 6.9.0679
    • * Wilcoxon signed rank test.

    • † Acetazolamide rCBF − resting rCBF.

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American Journal of Neuroradiology: 26 (5)
American Journal of Neuroradiology
Vol. 26, Issue 5
1 May 2005
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Cite this article
Jun Deguchi, Makoto Yamada, Hitoshi Kobata, Toshihiko Kuroiwa
Regional Cerebral Blood Flow After Acetazolamide Challenge in Patients with Dural Arteriovenous Fistula: Simple Way to Evaluate Intracranial Venous Hypertension
American Journal of Neuroradiology May 2005, 26 (5) 1101-1106;

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Regional Cerebral Blood Flow After Acetazolamide Challenge in Patients with Dural Arteriovenous Fistula: Simple Way to Evaluate Intracranial Venous Hypertension
Jun Deguchi, Makoto Yamada, Hitoshi Kobata, Toshihiko Kuroiwa
American Journal of Neuroradiology May 2005, 26 (5) 1101-1106;
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