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Figures
- Fig 1.
Regional brain atrophy measurement of the temporal lobes in a patient with secondary progressive multiple sclerosis. The top figure shows coronal 3D spoiled gradient-recalled acquisition in the steady state T1-weighted source image used for the segmentation of the temporal lobes. Panels A and C show the brain parenchyma–only and cerebrospinal fluid–only images of the right temporal lobe. Panels B and D show the same type of segmentation outputs in the left temporal lobe.
Tables
Linear regression analysis results
Block 1 Covariates Retained MRI Variables Partial r for primary predictor Change in R2 from Block 1 Mulitple R2 P Value Processing Speed and Working Memory Paced Auditory Serial Addition Test Age LVV 0.42 0.16 0.17 .030 Age, BDI LVV 0.47 0.21 0.22 .020 Symbol Digit Modalities Test Age LVV; Left Parietal 0.63 0.32 0.50 .001 Age, BDI Left Temporal; BPF; Right Temporal 0.64 0.31 0.61 .001 Auditory/Verbal Learning and Recent Memory CVLT-II Total Learning Age Left Temporal 0.55 0.17 0.30 .006 Age, BDI Left Temporal 0.57 0.17 0.32 .014 CVLT-II Delayed Recall Age Left Temporal; Left Occipital 0.56 0.15 0.45 .001 Age, BDI Left Temporal; Left Occipital 0.61 0.20 0.50 .001 Visual/Spatial Learning and Recent Memory BVMT-R Total Learning Age — 0.31 Age, BDI Left Temporal; Right Temporal 0.51 0.18 0.48 .001 BVMT-R Delayed Recall Age Left Temporal; Right Temporal 0.62 0.22 0.58 <.001 Age, BDI Left Temporal; Right Temporal 0.67 0.29 0.59 .001 Consistency of Learning CVLT-II Learning Consistency Age Left Frontal 0.44 0.17 0.19 .030 Age, BDI Left Frontal 0.44 0.16 0.20 .030 BVMT-R Learning Consistency Age Left Temporal 0.66 0.29 0.43 <.001 Age, BDI Left Temporal; Left Frontal 0.68 0.31 0.55 <.001 Note.—For each regression model, table shows the partial r between the first predictor controlling for variables entered in block 1 and the change in R2 after block 1. CVLT-II = California Verbal Learning Test second edition, BVMT-R = Brief Visuospatial Memory Test-Revised, BDI = Beck Depression Inventory, LVV = Lateral Ventricle Volume, BPF = Brain Parenchyma Fraction. Lobar region labels reflect regional brain parenchyma fractions.
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