Article Figures & Data
Figures
- Fig 1.
Coronal ADC map of the rat brain taken 1–2 hours post-HI shows the measurement of the area of reduced ADC by using a relative ADC threshold of 80% of the mean contralateral hemisphere ADC intensity.
- Fig 2.
Coronal T2WI (A) and DWI (B) sections of the rat brain at the level of the thalamus taken 1–2 hours post-HI show hyperintense areas in the right cerebral hemisphere, which are larger and more conspicuous on DWI than T2WI.
- Fig 3.
Scatterplot of ln(%LV on 80% ADC threshold) at early imaging versus %LV on histopathology.
Tables
- Table 1:
%LV using various MR imaging measurements at 1–2 hours and day 4 post-HI and %LV of irreversible infarct at day 10 post-HI
%LV Early T2WI 80% ADC 70% ADC 60% ADC Late T2WI Histopathology Max 10.85 48.07 45.82 39.03 35.01 44.19 Min 0 0.12 0 0 1.76 6.46 Mean 2.8 20.9 13.2 7.4 23.3 28.6 SD 3.5 14.5 14.0 11.7 8.6 7.8 Note:—Max indicates maximum; Min, minimum; Early T2WI, %LV on T2WI at 1–2 hours post-HI; 80% ADC, %LV on 80% ADC threshold at 1–2 hours post-HI; 70% ADC, %LV on 70% ADC threshold at 1–2 hours post-HI; 60% ADC, %LV on 60% ADC threshold at 1–2 hours post-HI; Late T2WI, %LV on T2WI at day 4 post-HI.
- Table 2:
Pearson correlation between ln(%LV) using various MR imaging measurements at 1–2 hours, day 4 post-HI, and %LV on histopathology at day 10 post-HI
%LV Early ln(T2WI) ln(80% ADC) ln(70% ADC) ln(60% ADC) Late ln(T2WI) Histopathology r 0.342 0.738 0.593 0.435 0.848 P 0.111 <0.001 0.003 0.038 <0.001 Late T2WI r 0.621 0.666 0.49 0.343 P 0.002 0.001 0.018 0.109 Note:—Late T2WI indicates %LV on T2WI at 4 days post-HI; Early ln(T2WI), ln transformation of %LV on T2WI at 1–2 hours post-HI; ln(80% ADC), ln transformation of %LV on 80% ADC threshold at 1–2 hours post-HI; ln(70% ADC), ln transformation of %LV on 70% ADC threshold at 1–2 hours post-HI; ln(60% ADC), ln transformation of %LV on 60% ADC threshold at 1–2 hours post-HI; Late ln(T2WI), ln transformation of %LV on T2WI at day 4 post-HI.
