Article Figures & Data
Figures
- Fig 1.
Maximum intensity projections of SPM2 results from group comparison of rCBF between patients with very early AD and age-matched healthy volunteers. Patients with very early AD showed significant decline of rCBF in bilateral posterior cingulate gyri, precunei, and inferior parietal cortices. Height threshold is <0.001, corrected for multiple comparisons.
- Fig 2.
ROC curves with data conversion to the core SPECT data for discrimination between patients with probable AD at the very early stage of MCI and age-matched healthy volunteers in a multicenter study by using the 3 indicators of severity, extent, and ratio.
- Fig 3.
Automated voxel-by-voxel Z-score analysis by comparison of a brain perfusion SPECT image of a 78-year-old man with probable AD and an MMSE score of 24 with the mean and SD of SPECT images of healthy volunteers after normalization to global mean cerebral blood flow values. Color-scaled Z-score maps ranging from 2.0 to 5.0 with extent threshold of 300 voxels are displayed by overlaying on transaxial sections and surface rendering of the spatially normalized MR imaging template. Red lines enclose a VOI with the most significant decline of rCBF in very early AD obtained from group comparison with healthy volunteers by SPM2. The severity, extent, and ratio are 2.18, 77.2%, and 3.56, respectively.
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