Article Figures & Data
Figures
- Fig 1.
A and B, ADCav maps of the brain at the level of the thalamus (A) and the cerebellum (B) are shown. The brain regions for which data were acquired include 4 gray matter regions (1 indicates cerebral cortex; 2, thalamus; 3, hippocampus; 4, cerebellar gray matter) and 4 white matter regions (5 indicates corona radiata; 6, centrum semiovale; 7, internal capsule; 8, cerebellar white matter).
- Fig 2.
T2 relaxation times of gray matter regions (cerebral cortex, thalamus, hippocampus, and cerebellar cortex and white matter regions (corona radiata, centrum semiovale, internal capsule, and cerebellar white matter [bottom]) were determined in unaffected and AMD cats. Significant increases in T2 were found in the white matter of AMD cats compared with unaffected cats (*P < .05). No significant differences in T2 were found between affected and normal cats when gray matter regions were compared.
- Fig 3.
ADCav of gray matter regions (cerebral cortex, thalamus, hippocampus, and cerebellar cortex and white matter regions (corona radiata, centrum semiovale, internal capsule, and cerebellar white matter [bottom]) were determined in unaffected and AMD cats. Significant decreases in ADVav were found in AMD cats in all gray and white matter regions examined (*P < .05).
- Fig 4.
A and B, H&E-stained sections of the cerebellar cortex (original magnification ×400) from a normal cat (A) and an AMD cat (B), showing cytoplasmic vacuolation and distention of Purkinje cells (arrowhead), granular cells (small arrow), and glia (large arrow). C and D, Luxol fast blue staining of the cerebellar white matter (original magnification ×50) from a normal cat (C) and an AMD cat (D). A decrease in myelination is seen as a decrease in stain intensity and as an increase in space between myelin sheaths. E and F, GFAP immunohistochemistry of the cerebellum (original magnification ×200) from a normal (E) and an AMD cat (F), showing diffuse astrogliosis (brown staining) present throughout the gray and white matter of affected cats.
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