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Research ArticleSPINE

Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series

R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen and D.F. Kallmes
American Journal of Neuroradiology April 2008, 29 (4) 642-648; DOI: https://doi.org/10.3174/ajnr.A0918
R.J. McDonald
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A.T. Trout
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L.A. Gray
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A. Dispenzieri
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K.R. Thielen
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D.F. Kallmes
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    Fig 1.

    Sagittal T1 MR imaging demonstrating fracture types. Stars indicate treated fractures. A, Type 1 fracture, considered probably osteoporotic in nature. Areas of preserved, high T1 signal intensity within the fractured vertebral body, without focal intravertebral lesion and no evidence for pedicle involvement or epidural or paraspinal disease (not shown). B, Type 2 fracture, indeterminate for underlying lesions. Diffusely low signal intensity marrow throughout the spine. No focal lesion or epidural or paraspinal lesion within the treated vertebral body. C, Type 3 fracture, with clear evidence for myelomatous lesion within the treated vertebral body.

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    Fig 2.

    Treated and affected levels. Vertebral level frequency histograms of 114 treated vertebral levels (A) and 216 affected vertebral levels (B) in the 67 patients composing the myeloma study population. Diffuse myeloma involvement (>10 vertebral bodies) was not included in this histogram.

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    Fig 3.

    Time to treatment. Time to treatment of myeloma study participants is shown as a function of a frequency histogram with each bin representing a 4-month period.

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    Fig 4.

    Objective clinical outcome scores over time. Mean (± SD) RDQ and analog pain scale (pain with rest and activity) scores are shown preoperatively (baseline), postoperatively, and 1 week, 1 month, 6 months, and 1 year after vertebroplasty.

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  • Subjective outcome scores collected throughout follow-up

    VariableTime
    Postoperation1 Week1 Month6 Months1 Year
    Rest pain+1.25+1.33+1.29+1.53+1.49
    Active pain+1.10+1.12+1.00+1.33+1.12
    Mobility+0.76+0.67+0.83+1.00
    Narcotic use+0.81+0.84+0.93+0.94
    • Note:—Subjective outcome scores as compared with preoperative status: +2 indicates total improvement; +1, some improvement; 0, no change; −1, worse. Scores were calculated as described in the Methods section. Mobility and narcotic use were not determined until 1 week had passed after treatment.

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American Journal of Neuroradiology: 29 (4)
American Journal of Neuroradiology
Vol. 29, Issue 4
April 2008
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Cite this article
R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen, D.F. Kallmes
Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series
American Journal of Neuroradiology Apr 2008, 29 (4) 642-648; DOI: 10.3174/ajnr.A0918

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Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series
R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen, D.F. Kallmes
American Journal of Neuroradiology Apr 2008, 29 (4) 642-648; DOI: 10.3174/ajnr.A0918
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  • Evaluating Treatment Strategies for Spinal Lesions in Multiple Myeloma: A Review of the Literature
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  • Vertebral Augmentation in Patients with Multiple Myeloma: A Pooled Analysis of Published Case Series
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  • Efficacy of Percutaneous Vertebroplasty for Multiple Synchronous and Metachronous Vertebral Compression Fractures
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    European Spine Journal 2009 18 9
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    E. Terpos, O. Sezer, P.I. Croucher, R. García-Sanz, M. Boccadoro, J. San Miguel, J. Ashcroft, J. Bladé, M. Cavo, M. Delforge, M.-A. Dimopoulos, T. Facon, M. Macro, A. Waage, P. Sonneveld
    Annals of Oncology 2009 20 8
  • Guidelines for supportive care in multiple myeloma 2011
    John A. Snowden, Sam H. Ahmedzai, John Ashcroft, Shirley D’Sa, Timothy Littlewood, Eric Low, Helen Lucraft, Rhona Maclean, Sylvia Feyler, Guy Pratt, Jennifer M. Bird
    British Journal of Haematology 2011 154 1
  • Primary Malignant Tumors of the Spine
    Narayan Sundaresan, Gerald Rosen, Stefano Boriani
    Orthopedic Clinics of North America 2009 40 1
  • Percutaneous Techniques in the Treatment of Spine Tumors
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    Spine 2009 34 Supplement
  • Risk factors for bone cement leakage in percutaneous vertebroplasty: a retrospective study of four hundred and eighty five patients
    Si-Yuan Zhu, Zhao-Ming Zhong, Qian Wu, Jian-Ting Chen
    International Orthopaedics 2016 40 6
  • Current Paradigms for Metastatic Spinal Disease: An Evidence-Based Review
    P. E. Kaloostian, A. Yurter, P. L. Zadnik, D. M. Sciubba, Z. L. Gokaslan
    Annals of Surgical Oncology 2014 21 1

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