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Research ArticleINTERVENTIONAL

Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single-Center Experience

D.H. Lee, A. Arat, H. Morsi, H. Shaltoni, J.R. Harris and M.E. Mawad
American Journal of Neuroradiology August 2008, 29 (7) 1389-1394; DOI: https://doi.org/10.3174/ajnr.A1070
D.H. Lee
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A. Arat
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H. Morsi
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H. Shaltoni
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J.R. Harris
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M.E. Mawad
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  • Fig 1.
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    Fig 1.

    Distribution of ARU in patients receiving dual antiplatelet therapy. Most patients are within the target inhibition range, <550 ARU (dotted line).

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    Fig 2.

    Distribution of values associated with clopidogrel response in patients receiving dual antiplatelet therapy. A, BASE value. B, PRU. C, Percentage inhibition. The working cutoff value is 40% (dotted line).

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    Fig 3.

    Variability of PRU according to the duration of dual antiplatelet therapy. CI indicates confidence interval.

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    Fig 4.

    Changes in PRUs (A) and percentage inhibition (% inhibition) (B) after an additional clopidogrel loading dose in 10 patients. Results are shown for initial (PRU1 and % inhibition1) and follow-up tests after an additional loading dose of clopidogrel (PRU2 and % inhibition2).

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    Table 1:

    Indications for dual antiplatelet therapy

    IndicationsNo. (%)
    Stent-assisted coiling of aneurysm60 (61.2)
    Stenting for intracranial artery stenosis19 (19.4)
    Stenting for extracranial cervical artery stenosis14 (14.3)
    Stenting for cervical artery dissection3 (3.1)
    Stent-assisted embolization of carotid cavernous fistula2 (2.0)
    Total98 (100)
    • View popup
    Table 2:

    Variability of dual antiplatelet therapy regime

    DurationRegimenDaysNo. (%)
    >10 daysASA + PVX after LD<1031 (31.6)
    5–10 daysASA + PVX after LD5–1049 (50.0)
    2–4 daysASA + PVX after LD2–45 (5.1)
    1 dayASA + LD + LD in the morning18 (8.2)
    Same dayASA + 2LDs05 (5.1)
    Total98 (100)
    • Note:—ASA indicates aspirin 325 mg daily; PVX, clopidogrel 75 mg daily; LD, clopidogrel 300 mg as a loading dose.

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American Journal of Neuroradiology: 29 (7)
American Journal of Neuroradiology
Vol. 29, Issue 7
August 2008
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Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single-Center Experience
D.H. Lee, A. Arat, H. Morsi, H. Shaltoni, J.R. Harris, M.E. Mawad
American Journal of Neuroradiology Aug 2008, 29 (7) 1389-1394; DOI: 10.3174/ajnr.A1070

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Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single-Center Experience
D.H. Lee, A. Arat, H. Morsi, H. Shaltoni, J.R. Harris, M.E. Mawad
American Journal of Neuroradiology Aug 2008, 29 (7) 1389-1394; DOI: 10.3174/ajnr.A1070
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