Article Figures & Data
Figures
- Fig 1.
A−E, A schematic diagram illustrates the sequential steps in constructing the stump aneurysm model in the right common carotid artery in a rat by using temporary (t) and permanent (p) sutures after Abrahams et al.37 The artery is small, even in adult rats, and only a short segment of coil, approximately 1 cm, could be fitted retrogradely into the arteriotomy site. F, In the final image, a permanent suture separates the coil site from the arteriotomy repair, whereas removal of the temporary ligature below exposes the coil to systemic circulatory conditions.
- Fig 2.
A, HE staining of representative slides from 4 subject groups. Sham (no coil) procedure (group 1) demonstrates no evidence of coil or intense neointimal response. B, Plain platinum coil (group 2) produces a relatively small degree of luminal distension and neointimal response. C and D, Vitronectin-coated platinum coil (group 3) and gold-coated platinum coil (group 4) produce increasing neointimal response and luminal distension, respectively (magnification 100×).
- Fig 3.
Graph shows the ratio of intimal-to-luminal cross-sectional area, expressed as mean ± SD, for 4 groups: no coil (sham controls), uncoated platinum coil, gold-coated platinum coil, or vitronectin-coated platinum coil. Numbers closer to 1 indicate a greater degree of histologic response. The asterisk (*) indicates a statistically significant difference compared with the sham control group. The dagger (†) indicates a statistically significant difference compared with the uncoated platinum group. Note that the ratio of intimal-to-luminal cross-sectional area is 53% higher for vitronectin-coated and 100% higher for the gold-coated platinum coils, compared with the uncoated platinum coil.
