Endovascular Approaches to Acute Stroke, Part 2: A Comprehensive Review of Studies and Trials

References

1. ↵
   Sussman BJ, Fitch TS. Thrombolysis with fibrinolysin in cerebral arterial occlusion. JAMA 1958;167:1705–09

   CrossRefPubMedWeb of Science
2. ↵
   Lisboa RC, Jovanovic BD, Alberts MJ. Analysis of the safety and efficacy of intra-arterial thrombolytic therapy in ischemic stroke. Stroke 2002;33:2866–71

   Abstract/FREE Full Text
3. ↵
   Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432–38

   Abstract/FREE Full Text
4. ↵
   Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 2008;39:1205–12

   Abstract/FREE Full Text
5. ↵
   McDougall C, Clark W, Mayer T, et al. The Penumbra Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in acute ischemic stroke. In: Proceedings of the International Stroke Conference, New Orleans. February 20–22,2008
6. ↵
   Nedeltchev K, Fischer U, Arnold M, et al. Long-term effect of intra-arterial thrombolysis in stroke. Stroke 2006;37:3002–07. Epub 2006 Oct 26

   Abstract/FREE Full Text
7. ↵
   Brekenfeld C, Remonda L, Nedeltchev K, et al. Endovascular neuroradiological treatment of acute ischemic stroke: techniques and results in 350 patients. Neurol Res 2005;27 (suppl 1):S29–35

   CrossRefPubMedWeb of Science
8. ↵
   Rha JH, Saver JL. The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007;38:967–73

   Abstract/FREE Full Text
9. ↵
   Ciccone A, Valvassori L, Gasparotti R, et al. Debunking 7 myths that hamper the realization of randomized controlled trials on intra-arterial thrombolysis for acute ischemic stroke. Stroke 2007;38:2191–95

   Abstract/FREE Full Text
10. ↵
    Yamaguchi T, Hayakawa T, Kiuchi H, et al. Intravenous tissue plasminogen activator ameliorates the outcome of hyperacute embolic stroke. Cerebrovasc Dis 1993;3:269–72

    CrossRef
11. ↵
    Wolpert SM, Bruckmann H, Greenlee R, et al. Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator: The rtPA Acute Stroke Study Group. AJNR Am J Neuroradiol 1993;14:3–13

    Abstract/FREE Full Text
12. Mori E, Yoneda Y, Tabuchi M, et al. Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology 1992;42:976–82

    Abstract/FREE Full Text
13. ↵
    Saqqur M, Uchino K, Demchuk AM, et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007;38:948–54

    Abstract/FREE Full Text
14. ↵
    Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke: the PROACT II study—a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11

    CrossRefPubMedWeb of Science
15. ↵
    Lindsberg PJ, Mattle HP. Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis. Stroke 2006;37:922–28

    Abstract/FREE Full Text
16. ↵
    Ducrocq X, Bracard S, Taillandier L, et al. Comparison of intravenous and intra-arterial urokinase thrombolysis for acute ischaemic stroke. J Neuroradiol 2005;32:26–32

    PubMedWeb of Science
17. ↵
    del Zoppo GJ, Higashida RT, Furlan AJ, et al. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke—PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 1998;29:4–11

    Abstract/FREE Full Text
18. ↵
    Ogawa A, Mori E, Minematsu K, et al. Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 2007;38:2633–39. Epub 2007 Aug 16

    Abstract/FREE Full Text
19. ↵
    Wechsler LR, Roberts R, Furlan AJ, et al. Factors influencing outcome and treatment effect in PROACT II. Stroke 2003;34:1224–29

    Abstract/FREE Full Text
20. ↵
    Hill MD, Rowley HA, Adler F, et al. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke 2003;34:1925–31

    Abstract/FREE Full Text
21. ↵
    Hill MD, Kent DM, Hinchey J, et al. Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study. Stroke 2006;37:2322–25

    Abstract/FREE Full Text
22. ↵
    Kent DM, Price LL, Ringleb P, et al. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke 2005;36:62–65

    Abstract/FREE Full Text
23. ↵
    Kase CS, Furlan AJ, Wechsler LR, et al. Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trial. Neurology 2001;57:1603–10

    Abstract/FREE Full Text
24. ↵
    Saver JL. Intra-arterial fibrinlysis for acute ischemic stroke: the message of MELT. Stroke 2007;38:2627–28. Epub 2007 Aug 16

    FREE Full Text
25. ↵
    Arnold M, Nedeltchev K, Mattle HP, et al. Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatry 2003;74:739–42

    Abstract/FREE Full Text
26. ↵
    Jansen O, von Kummer R, Forsting M, et al. Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol 1995;16:1977–86

    Abstract
27. ↵
    Zaidat OO, Suarez JI, Santillan C, et al. Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke 2002;33:1821–26

    Abstract/FREE Full Text
28. ↵
    Sorimachi T, Fujii Y, Tsuchiya N, et al. Recanalization by mechanical embolus disruption during intra-arterial thrombolysis in the carotid territory. AJNR Am J Neuroradiol 2004;25:1391–402

    Abstract/FREE Full Text
29. ↵
    Flint AC, Duckwiler GR, Budzik RF, et al. Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and Multi MERCI Part I trials. Stroke 2007;38:1274–80. Epub 2007 Mar 1

    Abstract/FREE Full Text
30. ↵
    Jovin TG, Gupta R, Uchino K, et al. Emergent stenting of extracranial internal carotid artery occlusion in acute stroke has a high revascularization rate. Stroke 2005;36:2426–30

    Abstract/FREE Full Text
31. ↵
    Aldrich EM, Lee AW, Chen CS, et al. Local intraarterial fibrinolysis administered in aliquots for the treatment of central retinal artery occlusion: the Johns Hopkins Hospital experience. Stroke 2008;39:1746–50

    Abstract/FREE Full Text
32. ↵
    Arnold M, Koerner U, Remonda L, et al. Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. J Neurol Neurosurg Psychiatry 2005;76:196–99

    Abstract/FREE Full Text
33. ↵
    Noble J, Weizblit N, Baerlocher MO, et al. Intra-arterial thrombolysis for central retinal artery occlusion: a systematic review. Br J Ophthalmol 2008;92:588–93

    Abstract/FREE Full Text
34. ↵
    Powers WJ. Intra-arterial thrombolysis for basilar artery thrombosis: trial it. Stroke 2007;38 (suppl):704–06

    Abstract/FREE Full Text
35. ↵
    Smith WS. Intra-arterial thrombolytic therapy for acute basilar occlusion: pro. Stroke 2007;38 (suppl):701–03

    Abstract/FREE Full Text
36. ↵
    Macleod MR, Davis SM, Mitchell PJ, et al. Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke. Cerebrovasc Dis 2005;20:12–17. Epub 2005 May 30

    CrossRefPubMedWeb of Science
37. ↵
    Zeumer H, Hacke W, Ringelstein EB. Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease. AJNR Am J Neuroradiol 1983;4:401–04

    Abstract/FREE Full Text
38. ↵
    Furlan A, Higashida R. Intra-arterial thrombolysis in acute ischemic stroke. In: Mohr JP, Choi DW, Grotta JC, et al, eds. Stroke: Pathophysiology, Diagnosis, and Management. 4th ed. Philadelphia: Churchill Livingstone;2004 :943–51
39. ↵
    Schulte-Altedorneburg G, Reith W, Bruckmann H, et al. Thrombolysis of basilar artery occlusion–intra-arterial or intravenous: is there really no difference? Stroke 2007;38:9, author reply 10–11. Epub 2006 Nov 22
40. ↵
    Schonewille WJ, Wijman CA, Michel P, et al. The basilar artery international cooperation study (BASICS). Int J Stroke 2007;2:220–23

    CrossRefPubMedWeb of Science
41. ↵
    Schonewille WJ, Algra A, Wijman CA, et al. Treatment and outcome in basilar artery occlusion: results from the basilar artery international cooperation study (BASICS) registry. In: Proceedings of the 17th European Stroke Conference, Nice, France. May 13–16,2008
42. ↵
    Nagel S, Schellinger PD, Hartmann M, et al. Therapy of acute basilar artery occlusion: intraarterial thrombolysis alone vs bridging therapy. Stroke 2009;40:140–46

    Abstract/FREE Full Text
43. ↵
    Lutsep HL, Rymer MM, Nesbit GM. Vertebrobasilar revascularization rates and outcomes in the MERCI and multi-MERCI trials. J Stroke Cerebrovasc Dis 2008;17:55–57

    CrossRefPubMed
44. ↵
    Levy EI, Firlik AD, Wisniewski S, et al. Factors affecting survival rates for acute vertebrobasilar artery occlusions treated with intra-arterial thrombolytic therapy: a meta-analytical approach. Neurosurgery 1999;45:539–45, discussion 545–48

    CrossRefPubMedWeb of Science
45. ↵
    Tomycz ND, Holm MB, Horowitz MB, et al. Extensive brainstem ischemia on neuroimaging does not preclude meaningful recovery from locked-in syndrome: two cases of endovascularly managed basilar thrombosis. J Neuroimaging 2008;18:15–17

    PubMed
46. ↵
    Lewandowski CA, Frankel M, Tomsick TA, et al. Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 1999;30:2598–605

    Abstract/FREE Full Text
47. ↵
    Wolfe T, Suarez JI, Tarr RW, et al. Comparison of combined venous and arterial thrombolysis with primary arterial therapy using recombinant tissue plasminogen activator in acute ischemic stroke. J Stroke Cerebrovasc Dis 2008;17:121–28

    CrossRefPubMed
48. ↵
    Ernst R, Pancioli A, Tomsick T, et al. Combined intravenous and intra-arterial recombinant tissue plasminogen activator in acute ischemic stroke. Stroke 2000;31:2552–57

    Abstract/FREE Full Text
49. ↵
    Suarez JI, Zaidat OO, Sunshine JL, et al. Endovascular administration after intravenous infusion of thrombolytic agents for the treatment of patients with acute ischemic strokes. Neurosurgery 2002;50:251–59, discussion 259–60

    CrossRefPubMedWeb of Science
50. ↵
    Hill MD, Barber PA, Demchuk AM, et al. Acute intravenous–intra-arterial revascularization therapy for severe ischemic stroke. Stroke 2002;33:279–82

    Abstract/FREE Full Text
51. ↵
    Shaltoni HM, Albright KC, Gonzales NR, et al. Is intra-arterial thrombolysis safe after full-dose intravenous recombinant tissue plasminogen activator for acute ischemic stroke? Stroke 2007;38:80–84

    Abstract/FREE Full Text
52. ↵
    Burns TC, Rodriguez GJ, Patel S, et al. Endovascular interventions following intravenous thrombolysis may improve survival and recovery in patients with acute ischemic stroke: a case-control study. AJNR Am J Neuroradiol 2008;29:1918–24

    Abstract/FREE Full Text
53. ↵
    Keris V, Rudnicka S, Vorona V, et al. Combined intraarterial/intravenous thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 2001;22:352–58

    Abstract/FREE Full Text
54. ↵
    IMS Study Investigators. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 2004;35:904–11. Epub 2004 Mar 11

    Abstract/FREE Full Text
55. ↵
    Tissue plasminogen activator for acute ischemic stroke: The National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group. N Engl J Med 1995;333:1581–87

    CrossRefPubMedWeb of Science
56. ↵
    IMS Study Investigators. Hemorrhage in the Interventional Management of Stroke study. Stroke 2006;37:847–51. Epub 2006 Jan 26

    Abstract/FREE Full Text
57. ↵
    Khatri P, Neff J, Broderick JP, et al. Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke 2005;36:2400–03

    Abstract/FREE Full Text
58. ↵
    Hill MD, Demchuk AM, Tomsick TA, et al. Using the baseline CT scan to select acute stroke patients for IV-IA therapy. AJNR Am J Neuroradiol 2006;27:1612–16

    Abstract/FREE Full Text
59. ↵
    IMS II Trial Investigators. The Interventional Management of Stroke (IMS) II Study. Stroke 2007;38:2127–35. Epub 2007 May 24

    Abstract/FREE Full Text
60. ↵
    Tomsick T, Broderick J, Carrozella J, et al. Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol 2008;29:582–87

    Abstract/FREE Full Text
61. ↵
    Nogueira RG, Schwamm LH, Hirsch JA. Endovascular approaches to acute stroke, part 1: drugs, devices, and data. AJNR Am J Neuroradiol 2009;30:649–61

    Abstract/FREE Full Text
62. ↵
    Nichols CW, Khatri P, Yeatts S, et al. Periprocedural sedation during intervention for acute stroke [abstract]. Stroke 2008;39:595
63. ↵
    King S, Khatri P, Carrozella J, et al. Anterior cerebral artery emboli in combined intravenous and intra-arterial rtPA treatment of acute ischemic stroke in the IMS I and II trials. AJNR Am J Neuroradiol 2007;28:1890–94

    Abstract/FREE Full Text
64. ↵
    Khatri P, Broderick JP, Khoury JC, et al. Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk. Stroke 2008;39:3283–87

    Abstract/FREE Full Text
65. ↵
    Khatri P, Martin R, Tomsick TA, et al. The clinical effect of mild hemorrhagic transformation after acute intra-arterial revascularization therapy: an exploratory analysis. Stroke 2008;39:559
66. ↵
    Molina CA, Alvarez-Sabin J, Montaner J, et al. Thrombolysis-related hemorrhagic infarction: a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion. Stroke 2002;33:1551–56

    Abstract/FREE Full Text
67. ↵
    Khatri P, Martin R, Hill M, et al. Hemorrhagic infarction after intra-arterial thrombolysis is not a marker of early, successful reperfusion [abstract]. Stroke 2009;40:2
68. ↵
    Khatri P, Abruzzo T, Yeatts SD, et al. Good outcome after technically successful intra-arterial therapy is time-dependent. Stroke 2008;39:560
69. ↵
    Nogueira RG, Liebeskind DS, Sung G, et al. Predictors of clinical outcomes in acute ischemic stroke patients undergoing thrombectomy: pooled analysis of the MERCI and Multi MERCI Trials [abstract]. Stroke 2009;40:26

    CrossRef
70. ↵
    Gobin YP, Starkman S, Duckwiler GR, et al. MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Stroke 2004;35:2848–54. Epub 2004 Oct 28

    Abstract/FREE Full Text
71. ↵
    Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke: results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. AJNR Am J Neuroradiol 2006;27:1177–82

    Abstract/FREE Full Text
72. ↵
    Devlin TG, Baxter BW, Feintuch TA, et al. The Merci Retrieval System for acute stroke: the Southeast Regional Stroke Center experience. Neurocrit Care 2007;6:11–21

    CrossRefPubMedWeb of Science
73. ↵
    Kim D, Jahan R, Starkman S, et al. Endovascular mechanical clot retrieval in a broad ischemic stroke cohort. AJNR Am J Neuroradiol 2006;27:2048–52

    Abstract/FREE Full Text
74. ↵
    Nogueira RG, Smith WS. Safety and efficacy of endovascular thrombectomy in patients with abnormal hemostasis: pooled analysis of the MERCI and multi MERCI trials. Stroke 2009;40:516–22

    Abstract/FREE Full Text
75. ↵
    Bose A, Henkes H, Alfke K, et al. The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol 2008;29:1409–13

    Abstract/FREE Full Text
76. ↵
    Tarr R, Alfke K, Stingele R, et al. Initial post-market experience of the Penumbra System: revascularization of large vessel occlusion in acute ischemic stroke in the United States and Europe [abstract]. Stroke 2009;40:46

    CrossRef
77. ↵
    Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29

    CrossRefPubMedWeb of Science
78. ↵
    Alexandrov AV, Molina CA, Grotta JC, et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004;351:2170–78

    CrossRefPubMedWeb of Science
79. ↵
    Josephson SA, Saver JL, Smith WS. Comparison of mechanical embolectomy and intraarterial thrombolysis in acute ischemic stroke within the MCA: MERCI and Multi MERCI compared to PROACT II. Neurocrit Care 2009;10:43–49. Epub 2008 Nov 22

    CrossRefPubMedWeb of Science
80. ↵
    Khatri P, Hill MD, Palesch YY, et al. Methodology of the Interventional Management of Stroke III Trial. Int J Stroke 2008;3:130–37

    CrossRefPubMedWeb of Science
81. ↵
    Molyneux A, Rothwell P. Pragmatic ischaemic stroke thrombectomy evaluation (PISTE): mechanical thrombectomy or revascularisation for acute ischaemic stroke—plans for a prospective randomised trial [abstract]. In: Proceedings of the 29th ABC-WIN Seminar, Val d'Isere, France. January 11–16,2009
82. ↵
    Nogueira RG, Liebeskind D, Gupta R, et al. DWI/PWI and CTP assessment in the triage of wake-up and late presenting strokes undergoing neurointervention: the DAWN Trial. In: Proceedings of the International Stroke Conference, San Diego, Calif. February 17–20,2009
83. ↵
    Hammer MD, Starkman S, Burgin WS, et al. Flo 24 Stroke Trial: safety and efficacy of NeuroFlo in 8–24 hour stroke patients [abstract]. Stroke 2009;40:142