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Research ArticleINTERVENTIONAL

Percutaneous Transluminal Angioplasty and Stent Placement in Acute Vessel Occlusion: Evaluation of New Methods for Interventional Stroke Treatment

C. Brekenfeld, P. Tinguely, G. Schroth, M. Arnold, M. El-Koussy, K. Nedeltchev, J.V. Byrne and J. Gralla
American Journal of Neuroradiology June 2009, 30 (6) 1165-1172; DOI: https://doi.org/10.3174/ajnr.A1541
C. Brekenfeld
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P. Tinguely
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G. Schroth
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M. Arnold
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M. El-Koussy
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K. Nedeltchev
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J.V. Byrne
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J. Gralla
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  • Fig 1.
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    Fig 1.

    Graph shows the mean recanalization rate after PTA and stent placement during the study interval.

  • Fig 2.
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    Fig 2.

    PTA performed for an occlusion of the LA. A, Angiogram before thrombus injection depicts side branches. Black arrows delineate the prospective position of the occluding thrombus. B, The microguidewire and PTA balloon are placed at the thrombus (open arrows). C and D, During balloon inflation (C), the thrombus is compressed and penetrates into side branches (red arrows) of the LA located contralateral to the balloon (D).

  • Fig 3.
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    Fig 3.

    A, The radiopaque thrombus (open arrowheads) is visualized in a branch of the maxillary artery. B, The microguidewire and balloon catheter have passed between the thrombus and the vessel wall. After balloon inflation, the thrombus is pressed to the contralateral side of the vessel. C, Due to insufficient length of the balloon (red arrow), a second PTA at the proximal end of the occlusion is performed. D, Follow-up angiogram reveals flow in the parent artery and reperfusion of a side branch ipsilateral to balloon placement (red asterisk).

  • Fig 4.
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    Fig 4.

    A, Occlusion of the maxillary artery in proximity to a sharp bend of the vessel. B and C, The stent (red arrows) is placed across the thrombus (B) and deployed (C). Again, the thrombus (open arrowheads) is compressed to the side contralateral to the initial passing procedure and is stabilized there (C). D, Follow-up angiogram reveals nearly complete recanalization.

  • Fig 5.
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    Fig 5.

    Stent placement performed for an occlusion of the LA. A, Assessment of vessel status before intervention (black arrowheads mark the prospective position of the thrombus). B and C, The microguidewire and stent catheter have passed the occlusion site (open arrowheads) on the left side (caudally, red arrow) on this lateral projection. D and E, The stent is deployed (open arrowheads), and the follow-up angiogram reveals reperfusion of an ipsilateral side branch (asterisk, E). Another side branch proximal to the occlusion is perfused through the mesh of the stent (curved red arrow, E).

Tables

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    Table 1:

    Results of PTA and stenting with postdilation for vessel recanalization

    PTAStentLevel of Significance
    Total No. of attempts1515NA
    Mean vessel diameter (mm)2.14 (±0.3)2.28 (±0.4)NS
    Mean time (min) per attempt16.6 (±5.0)33.0 (±15.1)P < .001*
    Total incidence of embolic events3/16 (20%)2/16 (13%)NS
    Mean recanalization rate (%)
    Immediately after PTA/stenting20.5%61.8%P < 0.001†
        P114.6%67.5%P < 0.001†
        P212.5%65.3%P < 0.001†
        P36.0%71.6%P < 0.001†
    • Note:—NA indicates not applicable; NS, not significant; PTA, percutaneous transluminal angioplasty; P1, 1 hour postintervention.

    • * Student t test.

    • † Variance analysis of repeated-measures.

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    Table 2:

    Recanalization results at different time points after PTA and stenting with postdilation according to the TIMI classification

    PTAStentP Value*
    TIMI 0TIMI 1TIMI 2TIMI 3TIMI 0TIMI 1TIMI 2TIMI 3
    0 hours† (n = 30)61802229.006
    P1* (n = 30)74402067.001
    P2* (n = 24)62401065.002
    P3* (n = 10)32000023.007
    • Note:—TIMI indicates Thrombolysis in Myocardial Infarction trial criteria.

    • * Mann-Whitney U test.

    • † Immediately.

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American Journal of Neuroradiology: 30 (6)
American Journal of Neuroradiology
Vol. 30, Issue 6
June 2009
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Cite this article
C. Brekenfeld, P. Tinguely, G. Schroth, M. Arnold, M. El-Koussy, K. Nedeltchev, J.V. Byrne, J. Gralla
Percutaneous Transluminal Angioplasty and Stent Placement in Acute Vessel Occlusion: Evaluation of New Methods for Interventional Stroke Treatment
American Journal of Neuroradiology Jun 2009, 30 (6) 1165-1172; DOI: 10.3174/ajnr.A1541

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Percutaneous Transluminal Angioplasty and Stent Placement in Acute Vessel Occlusion: Evaluation of New Methods for Interventional Stroke Treatment
C. Brekenfeld, P. Tinguely, G. Schroth, M. Arnold, M. El-Koussy, K. Nedeltchev, J.V. Byrne, J. Gralla
American Journal of Neuroradiology Jun 2009, 30 (6) 1165-1172; DOI: 10.3174/ajnr.A1541
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