MR Imaging Findings in 2 Cases of Late Infantile GM1 Gangliosidosis

1.5T MR images in an 8-year-old boy with GM1 gangliosidosis. A, Spin-echo T1-weighted image (TR/TE/NEX, 655 ms/15 ms/2) shows abnormal hyperintensity of the globus pallidum bilaterally (arrows). B, B0 diffusion-weighted image (TR/TE/NEX, 3072 ms/70 ms/1) confirms profound hypointensity of both pallida (arrows), consistent with paramagnetic effects. C, Axial fast spin-echo T2-weighted image (TR/TE/NEX, 4161 ms/100 ms/2) shows pallidal hypointensity (arrows) associated with hyperintensity of the posterior putamen bilaterally (arrowheads). Notice normal white matter signal intensity.