Article Figures & Data
Figures
- Fig 1.
Absolute and relative permeability maps for the gold standard 90- to 240-second acquisition and for the truncated acquisitions (90–210, 90–180, 90–150, and 90–120 seconds). Absolute and relative BBBP values are overlapping for the gold standard 90- to 240-second delayed acquisition and for the 90- to 210-second truncated analysis window. For shorter analysis windows (90–180 seconds and, especially, 90–150 and 90–120 seconds), absolute and relative BBBP values are overestimated. The map depicting PCT-determined infarct and penumbra at the same level is also presented for reference.
Tables
Characteristics Patients with Stroke No. of patients 23 No. of men (%) 8 (35%) Median age (years) 74 Interquartile range 59.5–82.5 Range 26–92 Median time from stroke to PCT (hours) 2.25 Interquartile range 1.5–5 Range 1–11.75 Stroke location ACA, MCA territories 3 MCA territory 20 ACA territory 0 PCA territory 0 Note:—ACA indicates anterior cerebral artery; MCA, middle cerebral artery; PCA, posterior cerebral artery; PCT, perfusion CT.
- Table 2:
Correlation of BBBP values from the truncated analysis windows with BBBP values from the gold standard 90- to 240-second delayed acquisition*
90–120 Seconds 90–150 Seconds 90–180 Seconds 90–210 Seconds Overall 0.89 (0.81–0.97) P = .012 0.93 (0.89–0.98) P = .022 0.98 (0.96–0.99) P = .42 0.99 (0.99–1.00) P = 1.000 Infarct 0.85 (0.71–0.99) P = .035 0.94 (0.89–0.98) P = .028 0.98 (0.97–1.00) P = .690 (0.99–1.00) P = 1.000 Penumbra 0.90 (0.80–1.00) P = .058 0.93 (0.87–1.00) P = .070 0.98 (0.96–0.99) P = .350 0.99 (0.99–1.00) P = 1.000 Nonischemic 0.91 (0.84–0.99) P = .048 0.94 (0.88–0.99) P = .061 0.98 (0.96–1.00) P = .400 0.99 (0.99–1.00) P = 1.000 Note:—BBBP indicates blood-brain barrier permeability surface product.
* For different regions of interest and different analysis windows, correlation coefficients and their 95% CIs are given. The P values provided are for a 1-sided test for H0: correlation ≥ .980.
- Table 3:
Absolute permeability measurements for the gold standard 90- to 240-second delayed acquisition and for the truncated analysis windows*
90–120 Seconds 90–150 Seconds 90–180 Seconds 90–210 Seconds 90–240 Seconds Nonischemic 4.62 (4.09–5.22) 3.28 (2.85–3.79) 2.51 (2.14–2.94) 2.05 (1.73–2.42) 1.82 (1.53–2.17) Infarct 4.92 (4.30–5.62) 3.51 (2.97–4.16) 2.72 (2.24–3.31) 2.24 (1.82–2.76) 2.00 (1.62–2.47) Penumbra 5.45 (4.81–6.17) 3.87 (3.36–4.46) 2.91 (2.50–3.39) 2.35 (2.01–2.74) 2.05 (1.75–2.41) * Mean absolute permeability (milliliters per 100 grams per minute) values and corresponding 95% CIs are shown for different regions of interest and different acquisition-time datasets.
- Table 4:
Relative permeability measurements for the gold standard 90- to 240-second delayed acquisition and for the truncated analysis windows*
90–120 Seconds 90–150 Seconds 90–180 Seconds 90–210 Seconds 90–240 Seconds Nonischemic 12% (10%–15%) 9% (7%–11%) 7% (5%–8%) 5% (4%–7%) 5% (4%–6%) Infarct 53% (45%–64%) 38% (31%–47%) 30% (23%–37%) 24% (19%–31%) 22% (17%–28%) Penumbra 26% (22%–32%) 19% (15%–23%) 14% (11%–18%) 11% (9%–14%) 10% (8%–13%) * Mean relative permeability values and corresponding 95% CIs are shown for different regions of interest and different acquisition-time datasets.
- Table 5:
√MSE calculated for the fitting of the Patlak line for the gold standard 90- to 240-second delayed acquisition and the truncated delayed acquisitions
90–120 Seconds 90–150 Seconds 90–180 Seconds 90–210 Seconds 90–240 Seconds Nonischemic 4.84 (3.95–5.95) 3.13 (2.65–3.71) 2.16 (1.84–2.54) 1.66 (1.41–1.95) 1.35 (1.14–1.59) Infarct 5.17 (4.10–6.52) 3.38 (2.73–4.19) 2.31 (1.87–2.84) 1.75 (1.43–2.15) 1.41 (1.15–1.73) Penumbra 5.31 (4.31–6.55) 3.42 (2.86–4.09) 2.35 (1.99–2.78) 1.79 (1.51–2.12) 1.44 (1.21–1.72) Note:—√MSE indicates root-mean-square error.
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