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Research ArticleInterventional

How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?

H.G. Morales, M. Kim, E.E. Vivas, M.-C. Villa-Uriol, I. Larrabide, T. Sola, L. Guimaraens and A.F. Frangi
American Journal of Neuroradiology November 2011, 32 (10) 1935-1941; DOI: https://doi.org/10.3174/ajnr.A2635
H.G. Morales
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M. Kim
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E.E. Vivas
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M.-C. Villa-Uriol
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I. Larrabide
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T. Sola
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L. Guimaraens
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A.F. Frangi
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    Fig 1.

    Results of virtual coiling for case 2. Untreated model (A) and treated models corresponding to coil packing densities of 5.6% (B), 11.2% (C), 16.7% (D), 22.2% (E), and 30.0% (F).

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    Fig 2.

    Blood flow velocity magnitudes in gray-scale for an aneurysm cross-section at peak systole for case 2. A, Changes in the velocity are presented with a fixed coil configuration and increasing packing density. B, Two coil configurations are compared for packing densities of 11.2% and 16.7%. The coils are presented in yellow and the percentages represent the packing densities achieved for each model.

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    Fig 3.

    WSS distributions for the untreated and several treated models for case 2, calculated at peak systole (A) and end diastole (B).

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    Fig 4.

    A, Time-averaged intra-aneurysmal mean flow velocity reduction rate. B, Time-averaged WSS in the aneurysm dome.

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    Fig 5.

    Variation of the aneurysm areas with low and high WSS expressed as a percentage of the whole aneurysm dome during one cardiac cycle for case 2. A, Untreated model. B and C, treated models with packing densities of 22.2% and 30.0%, respectively.

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    Table 1:

    Design parameters of virtual coiling experiments

    Case No.Volume of Aneurysm Region (mm3)Coil Diameter (mm)Coil Length (cm)Coil ShapeCoil Packing Density (%)
    11070.3045–30Straight6.8, 13.6, 20.0, 25.0, 31.5
    24230.4574–30Straight5.6, 11.2, 16.7, 22.2, 30.0
    36350.4574–30Straight7.0, 14.0, 21.0, 27.5, 32.0
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    Table 2:

    P values of ANOVA tests performed for each of the cases at different packing densities

    Case No.Packing Density (%)P Value Obtained from ANOVA Tests for
    Velocity Reduction RateAverage WSSLow WSS AreaHigh WSS Area
    120.0.001*.981.245.834
    25.0.064.988.833.886
    31.5.127.941.269.723
    222.2.000*.927.000*.309
    30.0.869.981.181.956
    321.0.000*.373.002*.163
    27.5.077.601.757.583
    32.0.155.655.760.552
    • ↵* Means significantly different due to coil configuration (P < .01).

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American Journal of Neuroradiology: 32 (10)
American Journal of Neuroradiology
Vol. 32, Issue 10
1 Nov 2011
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Cite this article
H.G. Morales, M. Kim, E.E. Vivas, M.-C. Villa-Uriol, I. Larrabide, T. Sola, L. Guimaraens, A.F. Frangi
How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?
American Journal of Neuroradiology Nov 2011, 32 (10) 1935-1941; DOI: 10.3174/ajnr.A2635

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How Do Coil Configuration and Packing Density Influence Intra-Aneurysmal Hemodynamics?
H.G. Morales, M. Kim, E.E. Vivas, M.-C. Villa-Uriol, I. Larrabide, T. Sola, L. Guimaraens, A.F. Frangi
American Journal of Neuroradiology Nov 2011, 32 (10) 1935-1941; DOI: 10.3174/ajnr.A2635
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