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Research ArticleInterventional

Endovascular Treatment Using Predominantly Stent-Assisted Coil Embolization and Antiplatelet and Anticoagulation Management of Ruptured Blood Blister–Like Aneurysms

S. Meckel, T.P. Singh, P. Undrén, B. Ramgren, O.G. Nilsson, C. Phatouros, W. McAuliffe and M. Cronqvist
American Journal of Neuroradiology April 2011, 32 (4) 764-771; DOI: https://doi.org/10.3174/ajnr.A2392
S. Meckel
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T.P. Singh
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P. Undrén
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B. Ramgren
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O.G. Nilsson
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C. Phatouros
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W. McAuliffe
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M. Cronqvist
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    Fig 1.

    A 50-year-old male patient presenting with HH grade I SAH. A, Transorbital view of the right ICA angiogram shows a small 1.3 × 1.7 mm BBA on the posteromedial ICA surface (arrow) on day 1 after ictus. B, Subsequent follow-up angiogram on day 4 shows no increase in size of the BBA (arrow). C, On day 10, marked expansion of the BBA, now measuring 2.6 × 2.9 mm, is noted (arrow). Stent-assisted coiling was subsequently performed on the same day. D, The final angiogram after placement of a single coil shows some residual filling of the BBA (arrow). E, Unsubtracted view of the final ICA angiogram after treatment demonstrates a single GDC coil inside the BBA (short white arrow) and end markers of the Neuroform stent within the supraclinoid ICA segment (long thin white arrows). F, Follow-up angiogram obtained 16 months after treatment reveals complete occlusion of the BBA.

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    Fig 2.

    A 49-year-old female patient who presented with severe SAH (Fisher/HH grades, 3/4). A and B, A very broad-based small BBA is found in the distal basilar artery trunk on initial DSA. C, At early angiographic follow-up on day 6, considerable growth of the BBA is noted (4.8 × 2.1 mm), prompting stent-assisted coiling. D, Angiogram immediately after treatment discloses residual proximal aneurysm filling. E, At 3 months' angiographic follow-up, progressive occlusion with a tiny dog ear remnant is evident. The patient made an excellent clinical recovery (mRS 1) at 5-month follow-up.

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    Table 1:

    Baseline characteristics of patients and BBAs

    PatientAge/SexFisher GradeaHH GradeaAneurysm Location/SideAneurysm Level/PositionSizea (neck × depth) (mm)Neck-Dome RatioAneurysm GrowthbAssociated Findings
    156/M11ICA/LC6-postmed1.7 × 1.51.1NoProx stenosis
    254/F31ICA/LC7-lateral2.4 × 1.91.3YesProx stenosis
    350/M21ICA/RC6-antmed2.6 × 2.90.9Yes
    446/F44ICA/RC6-antmed2.8 × 2.91.0Yes
    549/F34BA-TAnterior4.8 × 2.12.3Yes
    644/F32ICA/RC6–7 antlat6.8 × 2.13.2NoFusiform dilation
    744/M43ICA/RC6-antmed1.6 × 1.51.1Yes
    835/M11ICA/LC6-antmed2.5 × 1.51.7Yes
    950/M34ICA/RC6-med8.0 × 12.00.7NoPartially thrombosed
    1070/M42ICA/LC6-postmed5.0 × 2.02.5Yes
    1151/F11ICA/LC6-antmed3.3 × 3.70.9No
    1244/F21ICA/RC6–7 post7.0 × 8.00.7NoPartially thrombosed
    1344/F23BA-TAnterior3.0 × 2.01.5Yes
    • a Fisher and HH grade and aneurysm sizes are provided at the time of treatment.

    • b Aneurysm growth assessed between diagnosis and treatment.

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    Table 2:

    Peri- and postprocedural antiplatelet and anticoagulation regimensa

    No.Clopidogrel/Aspirin (oral) Pre-EVT (mg)Clopidogrel (NGT)/Aspirin (IV) Pre-Stent+Coil (mg)Clopidogrel (NGT)/Aspirin (IV) Post-Stent±Coil (mg)Clopidogrel (oral) Postprocedure (mg)/DurationAspirin (oral) Postprocedure (mg)/DurationHeparin Postprocedure/Duration
    1–150/0150/075/1.5 Months150/6 MonthsIV/1 day + LMWH/1 week
    20/300–––150/1 MonthIV/3 days
    30/300300/0–75/2 Months100/LifetimeLow-dose s.c./14 days
    4300/300––75/1 Day100/1 DayIV/2 days
    5–0/300 (NGT)150/0–150/LifetimeIV/0.5 days
    6–––––IV/1.5 days
    7–150/0150/075/3 Days75/12 Months–
    80/320–150/075/1 Month75/3 Months–
    9–300b/500b–75/1 Month75/3 Months–
    10–150/0150/075/1 Month75/3 Months–
    11–300b/300b–75/3 Months–IV/0.5 day + LMWH/6 days
    12–0/5000/15075/1 Month75/3 Months–
    13–150/075/30075/3 Months150/6 Months–
    • a All patients received intraprocedural IV heparin aiming at an ACT >2 × baseline.

    • b Postcoil and prestent.

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American Journal of Neuroradiology: 32 (4)
American Journal of Neuroradiology
Vol. 32, Issue 4
1 Apr 2011
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Endovascular Treatment Using Predominantly Stent-Assisted Coil Embolization and Antiplatelet and Anticoagulation Management of Ruptured Blood Blister–Like Aneurysms
S. Meckel, T.P. Singh, P. Undrén, B. Ramgren, O.G. Nilsson, C. Phatouros, W. McAuliffe, M. Cronqvist
American Journal of Neuroradiology Apr 2011, 32 (4) 764-771; DOI: 10.3174/ajnr.A2392

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Endovascular Treatment Using Predominantly Stent-Assisted Coil Embolization and Antiplatelet and Anticoagulation Management of Ruptured Blood Blister–Like Aneurysms
S. Meckel, T.P. Singh, P. Undrén, B. Ramgren, O.G. Nilsson, C. Phatouros, W. McAuliffe, M. Cronqvist
American Journal of Neuroradiology Apr 2011, 32 (4) 764-771; DOI: 10.3174/ajnr.A2392
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