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Research ArticleInterventional

A Large and Giant Bifurcation Aneurysm Model in Canines: Proof of Feasibility

R. Ysuda, C.M. Strother, B. Aagaard-Kienitz, K. Pulfer and D. Consigny
American Journal of Neuroradiology March 2012, 33 (3) 507-512; DOI: https://doi.org/10.3174/ajnr.A2789
R. Ysuda
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C.M. Strother
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B. Aagaard-Kienitz
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K. Pulfer
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D. Consigny
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    Fig 1.

    Arterial structures of (A) bifurcation and (B) terminal. Adapted from Strother, Graves, and Rappe.28

  • Fig 2.
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    Fig 2.

    Bilateral external jugular veins are harvested. A, The vein grafts are split to make 2 venous sheets. B, These sheets are trimmed into a shape that would fit into the bifurcation arterial structure. The sheets are then mounted on a device, shown in D, in a way such that the original adventitial side is on the exterior surface. C, A handmade device to facilitate venous pouch preparation. Note that, by using 2 clamps, tension is made on the suture line to facilitate the procedure.

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    Fig 3.

    Incorporation of the venous pouch into the arterial structure. A, At this point, the venous pouch still remains on the device shown in Fig 2D, so as to keep the venous pouch cylindrical and thus facilitate suturing. B, The top of the venous pouch is also sutured. C, Completion of “aneurysm” creation after achieving hemostasis.

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    Fig 4.

    Images acquired at the second follow-up angiogram. A, B, and C represent images of aneurysms from dogs 1, 2, and 3, respectively. Except in 1 case (F, dog 6), all the aneurysms remain patent. In cases H and I (dogs 8 and 9), PTFE was used along with vein grafts.

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    Table 1:

    Case summary

    Dog #Artery“Aneurysm” Sac1st f/u2nd f/uComment
    1BifurcationVein graftIV (2)IA (4)
    2BifurcationVein graftIV (1)IA (3)
    3BifurcationVein graftIV (1)IA (3)
    4BifurcationVein graftIV (3)IA (6)
    5BifurcationVein graftIV (3)IA (6)
    6BifurcationVein graftIV (3)IA (12)An aneurysm was thrombosed
    7BifurcationVein graftIV (3)IA (6)
    8BifurcationVein graft + PTFEIA (2)*Dog was sacrificed after the 1st f/u due to sickness
    9TerminalVein graft + PTFEIV (3)IA (7)
    • Note:—IV and IA represent a modality employed for the follow-up study. A number in parentheses represents the interval in weeks between aneurysm creation and each follow-up study. Animals were sacrificed on the day following the 2nd follow-up. f/u indicates follow-up study; IV, intravenous digital subtraction angiogram; IA, intra-arterial digital subtraction angiogram.

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    Table 2:

    Aneurysm dimensions

    Dog #Height (mm)Dog #Neck Width (mm)
    1st f/u2nd f/uDif.1st f/u2nd f/uDif.
    119.020.01.018.99.90.9
    225.225.1−0.229.610.61.0
    321.724.12.438.69.61.1
    430.131.51.4411.013.22.3
    522.321.7−0.658.48.3−0.1
    6***6***
    722.923.20.378.89.00.2
    821.6**810.4**
    920.920.1−0.898.57.7−0.8
    Mean23.023.7Mean9.39.8
    SD3.44.0SD1.01.8
    Dog #Dome Width (mm)CasesVolume (mm3)/Ostium Area (mm2)
    1st f/u2nd f/uDif.VolumeOstium AreaVOR
    110.111.41.411552.054.828.3
    210.511.81.322576.590.428.5
    310.512.41.932319.995.824.2
    413.414.41.044595.0172.326.7
    510.912.21.352287.568.533.4
    6***6***
    712.112.20.172601.289.229.2
    818.6**82418.164.137.7
    920.722.82.193350.373.445.7
    Mean13.313.9Mean2712.688.631.7
    SD4.14.0SD906.336.77.0
    • Note:—Volume and the area of the ostium were measured only for the second follow-up study.

    • ↵* For dog 6, no measurements were performed because of spontaneous thrombosis. f/u indicates follow-up; Dif., difference.

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American Journal of Neuroradiology: 33 (3)
American Journal of Neuroradiology
Vol. 33, Issue 3
1 Mar 2012
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R. Ysuda, C.M. Strother, B. Aagaard-Kienitz, K. Pulfer, D. Consigny
A Large and Giant Bifurcation Aneurysm Model in Canines: Proof of Feasibility
American Journal of Neuroradiology Mar 2012, 33 (3) 507-512; DOI: 10.3174/ajnr.A2789

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A Large and Giant Bifurcation Aneurysm Model in Canines: Proof of Feasibility
R. Ysuda, C.M. Strother, B. Aagaard-Kienitz, K. Pulfer, D. Consigny
American Journal of Neuroradiology Mar 2012, 33 (3) 507-512; DOI: 10.3174/ajnr.A2789
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