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Research ArticleBrain

Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study

R. Jain, L. Poisson, J. Narang, L. Scarpace, M.L. Rosenblum, S. Rempel and T. Mikkelsen
American Journal of Neuroradiology August 2012, 33 (7) 1343-1348; DOI: https://doi.org/10.3174/ajnr.A2956
R. Jain
aFrom the Division of Neuroradiology, Departments of Radiology (R.J., J.N.)
bNeurosurgery (R.J., L.S., M.L.R., S.R., T.M.)
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L. Poisson
cPublic Health Sciences (L.P.), Henry Ford Health System, Detroit, Michigan.
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J. Narang
aFrom the Division of Neuroradiology, Departments of Radiology (R.J., J.N.)
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L. Scarpace
bNeurosurgery (R.J., L.S., M.L.R., S.R., T.M.)
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M.L. Rosenblum
bNeurosurgery (R.J., L.S., M.L.R., S.R., T.M.)
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S. Rempel
bNeurosurgery (R.J., L.S., M.L.R., S.R., T.M.)
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T. Mikkelsen
bNeurosurgery (R.J., L.S., M.L.R., S.R., T.M.)
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    Fig 1.

    Perfusion CT maps. Base image (A), CBV (B), and PS maps (C) show placement of a freehand ROI, including the solid enhancing part of the tumor and excluding any cystic/necrotic parts.

  • Fig 2.
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    Fig 2.

    Expression map showing genes with significant correlation ordered by hierarchic clustering with samples ordered by increasing PS (left) and CBV (right). Gene-expression levels are indicated relative to the probewise mean expression (black), with higher values in red and lower values in green. The summary bar at the top of the figure uses a similar color scheme to denote the level of the perfusion parameter. Genes with significant probes in both lists are highlighted with yellow circles.

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American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
Vol. 33, Issue 7
1 Aug 2012
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R. Jain, L. Poisson, J. Narang, L. Scarpace, M.L. Rosenblum, S. Rempel, T. Mikkelsen
Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study
American Journal of Neuroradiology Aug 2012, 33 (7) 1343-1348; DOI: 10.3174/ajnr.A2956

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Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study
R. Jain, L. Poisson, J. Narang, L. Scarpace, M.L. Rosenblum, S. Rempel, T. Mikkelsen
American Journal of Neuroradiology Aug 2012, 33 (7) 1343-1348; DOI: 10.3174/ajnr.A2956
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