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Research ArticleSpine
Open Access

Patient-Specific 3D Simulation of Cyclic CSF Flow at the Craniocervical Region

G. Rutkowska, V. Haughton, S. Linge and K.-A. Mardal
American Journal of Neuroradiology October 2012, 33 (9) 1756-1762; DOI: https://doi.org/10.3174/ajnr.A3047
G. Rutkowska
bCenter for Biomedical Computing (G.R., S.L., K.-A.M.), Simula Research Institute, Lysaker, Norway
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V. Haughton
aFrom the Department of Radiology, University of Wisconsin (V.H.), Madison, Wisconsin
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S. Linge
bCenter for Biomedical Computing (G.R., S.L., K.-A.M.), Simula Research Institute, Lysaker, Norway
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K.-A. Mardal
bCenter for Biomedical Computing (G.R., S.L., K.-A.M.), Simula Research Institute, Lysaker, Norway
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Figures

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  • Fig 1.
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    Fig 1.

    Model of the subarachnoid space for 1 subject.

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    Fig 2.

    Sagittal MR image (A) showing the axial image locations and an example of a Paraview image of the velocities computed for the sagittal and the axial locations (B).

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    Fig 3.

    Paraview image showing an example of systolic velocities in sagittal and multiple axial planes in a typical patient with a Chiari I malformation. Note that the C5 level has the fastest CSF velocities.

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    Fig 4.

    Paraview image showing an example of systolic velocities in sagittal and multiple axial planes in a volunteer. C4 has the peak CSF velocities.

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    Fig 5.

    Paraview snapshot image showing an example of velocities during systole in a patient with Chiari I post–craniovertebral decompression.

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    Fig 6.

    Paraview image showing an example of flow jets at multiple axial levels in a patient with Chiari I (A) and at the level of C4 in the same patient (B).

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    Fig 7.

    Paraview image of the pressure gradients at 4 times during the cardiac cycle. Pressure gradient has maximum value at t = 0.25 and 0.75 when flow is reversing and equals zero at t = 0 and 0.5 when CSF velocity is near maximum.

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    Fig 8.

    Comparison of velocities in simulations with velocities measured with PCMR in 5 patients (A) and in 5 locations in 1 patient (B).

Tables

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    Table 1:

    Gender, age, tonsilar herniation, and presence of syrinx in the patients with Chiari I

    Chiari I PatientsSexAgeTonsilar Herniation (mm)Syrinx
    1M212No
    2M49No
    3F513No
    4F306No
    5F405No
    6M105No
    7F165No
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    Table 2:

    Gender, age, and reason selected for the control subjects

    ControlsSexAgeStatus
    8NAAdult volunteer
    9NAAdult volunteer
    10F13Patient with no suspected CSF flow abnormality
    • Note:—NA indicates not available.

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    Table 3:

    Gender, age, and presence of syrinx in the postoperative patients with Chiari I

    Patients with Chiari I Post–Craniovertebral DecompressionSexAgeSyrinx
    11M54C1 to T10
    12F31Cervical
    13M3No
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    Table 4:

    Peak systolic and diastolic velocities and synchronous bidirectional flow in the patients with Chiari I, controls, and postoperative patients

    Peak Systolic Velocity (cm/s)Peak Diastolic Velocity (cm/s)Magnitude of Bidirectional Flow (cm/s)Duration of Bidirectional Flow (sec)
    Patients with Chiari I
        112.110.97.20.24
        211.911.87.60.30
        311.511.47.50.22
        411.48.86.00.38
        59.48.05.40.24
        67.77.64.90.20
        77.56.94.50.24
        Average10.29.36.20.26
    Controls
        86.86.53.80.22
        97.57.43.20.22
        107.97.55.30.18
        Average7.47.14.10.20
    Postoperative patients with Chiari I
        1110.09.95.50.22
        128.37.84.40.22
        1315.615.77.30.18
        Average11.311.15.70.21
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American Journal of Neuroradiology: 33 (9)
American Journal of Neuroradiology
Vol. 33, Issue 9
1 Oct 2012
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G. Rutkowska, V. Haughton, S. Linge, K.-A. Mardal
Patient-Specific 3D Simulation of Cyclic CSF Flow at the Craniocervical Region
American Journal of Neuroradiology Oct 2012, 33 (9) 1756-1762; DOI: 10.3174/ajnr.A3047

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Patient-Specific 3D Simulation of Cyclic CSF Flow at the Craniocervical Region
G. Rutkowska, V. Haughton, S. Linge, K.-A. Mardal
American Journal of Neuroradiology Oct 2012, 33 (9) 1756-1762; DOI: 10.3174/ajnr.A3047
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