Article Figures & Data
Tables
- Table 1:
Demographics of complete study sample including before (group A) and after (group B) initiation of tailored clopidogrel dosing
All Group A (49) Group B (47) P Value Male sex 58% 55% 62% .51 Age (yr) 63.9 ± 13.6 61.7 ± 14.4 66.1 ± 12.5 .12 Weight (kgs) 81.8 ± 20.2 78.6 ± 17.4 85.2 ± 22.4 .11 Hypertension 65 (68%) 30 (61%) 35 (74%) .17 Diabetes mellitus 32 (33%) 16 (33%) 16 (34%) .88 History of stroke 28 (29%) 18 (37%) 10 (21%) .09 Statin use 53 (55%) 27 (55%) 26 (55%) .92 Smoker 38 (40%) 16 (33%) 22 (47%) .16 Alcohol intake 23 (24%) 9 (18%) 14 (30%) .19 Platelet count (103/μL) 237 ± 79 239 ± 85 234 ± 72 .75 Demographics Mean Platelet Inhibition (%) P Value Age (yr) <55 years (n = 22) 38.6 .752 >55 years (n = 74) 36.7 Sex (No.) Women (n = 40) 39.1 .509 Men (n = 56) 35.7 Medical history Hypertension (No.) No (n = 31) 40.4 .355 Yes (n = 65) 35.5 Diabetes (No.) No (n = 64) 40.9 .029 Yes (n = 32) 29.4 Hyperlipidemia (No.) No (n = 50) 33.1 .067 Yes (n = 46) 42.2 Coronary artery disease (No.) No (n = 75) 37.7 .652 Yes (n = 21) 35.0 Prior stroke (No.) No (n = 68) 39.0 .254 Yes (n = 28) 32.7 Statin use (n = No.) No (n = 38) 30.0 .012 Yes (n = 54) 42.7 Aspirin use (No.) No (n = 19) 34.0 .491 Yes (n = 73) 38.3 Group Diagnosis Sex Age (yr) Clopidogrel Resistance PRU % Inhibition Thromboembolic Event 30-Day Follow-Up A Bilateral carotid artery dissection Female 53 Yes 298 3% Post-op in-stent thrombosis with TIA, required 1 ECA-ICA bypass Normal A Right internal carotid artery occlusion, secondary to right carotid artery dissection Male 42 Yes 291 0% Perioperative R frontal stroke Normal (recovered) A Basilar apex aneurysm Female 48 Yes 289 0% R cerebellar stroke POD 1 Dizziness (resolved) A Right MCA stenosis Female 77 Yes 235 0% Intra-op in-stent thrombus formation treated with IA abciximab; right basal ganglia stroke Nonfocal; psychomotor retardation A Left hemisphere subcortical subacute infarct, left MCA severe stenosis Male 68 Yes 360 0% Periprocedural in-stent thrombosis, required ECA-ICA bypass Dysarthria and R hemiparesis B Giant left MCA aneurysm Male 75 Yes 243 0% Stroke after being decreased from double clopidogrel dose Right-handed weakness (resolved) B MCA stenosis Male 79 No 30 80% L MCA small vessel stroke in the MCA stent distribution Mild word-finding difficulty (resolved) Note:—ECA indicates external carotid artery; R, right; POD, post-operative day; intra-op, introperative; L, left; PcomA, posterior communicating artery; IA, intra-arterial; PCA, posterior cerebral artery; Post-op, postoperative; periop, perioperative.
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