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Research ArticleSpineF

Spinal Meningeal Diverticula in Spontaneous Intracranial Hypotension: Analysis of Prevalence and Myelographic Appearance

P.G. Kranz, S.S. Stinnett, K.T. Huang and L. Gray
American Journal of Neuroradiology June 2013, 34 (6) 1284-1289; DOI: https://doi.org/10.3174/ajnr.A3359
P.G. Kranz
aFrom the Departments of Radiology (P.G.K., K.T.H., L.G.)
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S.S. Stinnett
bBiostatistics and Bioinformatics (S.S.S.)
cOphthalmology (S.S.S.), Duke University Medical Center, Durham, North Carolina.
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K.T. Huang
aFrom the Departments of Radiology (P.G.K., K.T.H., L.G.)
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L. Gray
aFrom the Departments of Radiology (P.G.K., K.T.H., L.G.)
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  • Fig 1.
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    Fig 1.

    A 58-year-old woman with positional headaches and tinnitus. A, Curved plane reformatted image from a CT myelogram demonstrates numerous spinal meningeal diverticula of varying sizes (arrowheads); no CSF leak was directly visualized. B, Coronal T1 postcontrast image from an MR image obtained before treatment shows diffuse smooth dural enhancement (arrows) and pituitary enlargement, compatible with SIH. C, Coronal T1 postcontrast image obtained following blood patching targeting the diverticula seen in A shows resolution of the imaging findings of SIH. The patient's symptoms completely resolved following treatment.

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    Fig 2.

    Classification of diverticular morphology. Lesions were categorized as either round (A) or multilobulated (B) on the basis of analysis of axial images from CT myelography.

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    Fig 3.

    Classification of diverticular size. On the basis of the maximum diameter of the diverticulum on an axial CT myelogram, lesions were trichotomized into 3 groups: 0–3 (A), 4–6 (B), or >6 mm (C).

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    Fig 4.

    Axial CT myelogram obtained immediately following intrathecal contrast administration in a patient with SIH shows an extrathecal contrast collection. These rapidly filling collections indicate the presence of a high-flow CSF leak.

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    Fig 5.

    Axial CT myelogram shows filling of the proximal nerve root sheaths bilaterally, findings seen intermittently in both controls and patients with SIH that we classified as “prominent” nerve root sheaths.

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    Fig 6.

    Incidental spinal diverticula in a control patient. Axial CT myelograms demonstrate multiple thoracic spinal diverticula in a 48-year-old woman. The patient underwent the myelography for postoperative back pain; she had no history of headache or other symptoms suggestive of SIH.

Tables

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    Table 1:

    Demographic data

    ControlSIHP Value
    Age (mean) (SD) (yr)55.56 (13.85)50.37 (13.27)
        Min/median/max35/58/7730/52/81.186a
    Sex
        Male (No.) (%)12 (67)5 (26)
        Female (No.) (%)6 (33)14 (74).014b
    • Note:—Min indicates minimum; max, maximum.

    • ↵a P value based on the Wilcoxon rank sum test of the difference between medians.

    • ↵b P value based on a χ2 test of the difference in proportions.

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    Table 2:

    Prevalence of spinal meningeal diverticula by sex

    Diverticula per PatientMaleFemaleP Valuea
    Mean (SD)1.6 (2.3)6.5 (7.9).166
    Min/median/max0/1/70/1.5/23
    • Note:—Min indicates minimum; max, maximum.

    • ↵a P value based on the Wilcoxon rank sum test of the difference between medians.

    • View popup
    Table 3:

    Prevalence of spinal meningeal diverticula and prominent nerve sheaths

    ControlSIHP Value
    Patients with diverticula present (No.) (%)8 (44)13 (68).141a
    Diverticula per patient (mean)2.2 (3.3)6.3 (8.0).099b
        Min/median/max0/0/100/2/23
    Patients with prominent nerve sheaths present (No.) (%)14 (78)17 (89).405c
    Prominent nerve sheaths per patient (mean)2.6 (3.1)6.1 (4.2).004c
        Min/median/max0/1.5/130/5/15
    • Note:—Min indicates minimum; max, maximum.

    • ↵a P value based on a χ2 test of the difference between proportions.

    • ↵b P value based on the Wilcoxon rank sum test of the difference between medians.

    • ↵c P value based on the Fisher exact test of the difference between proportions.

    • View popup
    Table 4:

    Comparison of myelographic appearance of spinal meningeal diverticula

    ControlSIHP Valuea
    Morphology
        Round (No.) (%)20 (51)62 (52).946
        Multilobulated (No.) (%)19 (49)57 (48)
    Size
        0–3 mm (No.) (%)9 (23)22 (18).711
        4–6 mm (No.) (%)23 (59)71 (60)
        >6 mm (No.) (%)7 (18)26 (22)
    Location
        Cervical (No.) (%)2 (5)4 (3)0.050
        Upper thoracic (No.) (%)6 (15)33 (28)
        Lower thoracic (No.) (%)29 (75)65 (55)
        Lumbar (No.) (%)2 (5)17 (14)
    • ↵a P value based on the generalized estimating equations test of the difference between groups in proportions in morphologic categories while accounting for multiple observations per patient.

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American Journal of Neuroradiology: 34 (6)
American Journal of Neuroradiology
Vol. 34, Issue 6
1 Jun 2013
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Cite this article
P.G. Kranz, S.S. Stinnett, K.T. Huang, L. Gray
Spinal Meningeal Diverticula in Spontaneous Intracranial Hypotension: Analysis of Prevalence and Myelographic Appearance
American Journal of Neuroradiology Jun 2013, 34 (6) 1284-1289; DOI: 10.3174/ajnr.A3359

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Spinal Meningeal Diverticula in Spontaneous Intracranial Hypotension: Analysis of Prevalence and Myelographic Appearance
P.G. Kranz, S.S. Stinnett, K.T. Huang, L. Gray
American Journal of Neuroradiology Jun 2013, 34 (6) 1284-1289; DOI: 10.3174/ajnr.A3359
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