White Matter Water Diffusion Changes in Primary Sjögren Syndrome

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Fig 1.
Tract-based spatial statistics results demonstrate voxelwise comparisons between 19 patients with pSS and 16 control subjects. Statistical maps (thresholded at threshold-free cluster enhancement, P < .01) are overlaid onto the mean FA skeleton and the Montreal Neurological Institute 152 template. Decreased fractional anisotropy in patients with pSS is shown in red (A), increased mean diffusivity is shown in blue (B), decreased axial diffusivity is shown in orange-yellow (C), and increased radial diffusivity is shown in gray (D). A, Corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, inferior fronto-occipital fasciculus, uncinate fasciculus, and inferior longitudinal fasciculus; B, superior longitudinal fasciculus, thalamic radiation, inferior fronto-occipital fasciculus, uncinate fasciculus and inferior longitudinal fasciculus, corticospinal tract, cingulum, genu, and splenium of the corpus callosum; C, superior longitudinal fasciculus, thalamic radiation, inferior fronto-occipital fasciculus, uncinate fasciculus and inferior longitudinal fasciculus, corticospinal tract, cingulum, and genu and splenium of the corpus callosum; D, superior longitudinal fasciculus, thalamic radiation, inferior fronto-occipital fasciculus, uncinate fasciculus, inferior longitudinal fasciculus, corticospinal tract, and cingulum.

Table 1:

Demographic and clinical characteristics of 19 patients with pSS

	Patients With pSS
Age, mean ± SD	64.73 ± 9.1 years
Sex, female:male	19:0
Disease duration, mean ± SD	11.5 ± 7.56 years
Dry mouth	94.7%
Dry eyes	94.7%
Positive salivary gland biopsy	100%
Arthritis/arthralgia	63.2%
Raynaud phenomenon	47.4%

Table 2:

Neuroanatomic regions with reduced FA in patients with pSS compared with control subjects

Anatomic Region	MNI Coordinates, mm			Cluster Size
Anatomic Region	x	y	z	Cluster Size
Right superior corona radiata, superior longitudinal fasciculus, anterior and posterior limb of internal capsule, inferior fronto-occipital fasciculus, uncinate fasciculus	27	8	26	4286
Left anterior thalamic radiation	−8	−18	0	284
Left inferior longitudinal fasciculus, uncinate fasciculus, inferior fronto-occipital fasciculus	−46	7	−20	202
Right anterior thalamic radiation, inferior longitudinal fasciculus	10	−17	5	103
Left anterior limb of internal capsule, anterior thalamic radiation	−23	7	14	92
Left superior corona radiata, superior longitudinal fasciculus, corticospinal tract	−28	−15	21	73
Left anterior thalamic radiation	−16	15	−6	67
Left inferior longitudinal fasciculus, uncinate fasciculus	−44	4	−36	65
Left anterior limb of internal capsule, anterior thalamic radiation	−20	0	11	46
Left inferior longitudinal fasciculus	−16	3	−5	38