Index by author

Serial T1WI and ¹H-MR spectroscopy data were acquired in 15 healthy individuals at normohydration, at 12 hours of dehydration, and during 1 hour of oral rehydration. Osmotic challenges were monitored by serum measures, including osmolality and hematocrit. With dehydration, serum osmolality increased by 0.67% and brain tissue fluid decreased by 1.63%. MR imaging morphometry demonstrated corresponding decreases of cortical thickness and volumes of the whole brain, cortex, white matter, and hypothalamus/thalamus. These changes reversed during rehydration. The authors conclude that it is essential to control for hydration levels in studies on brain morphometry and metabolism in order to avoid confounding the findings.

Serial T1WI and ¹H-MR spectroscopy data were acquired in 15 healthy individuals at normohydration, at 12 hours of dehydration, and during 1 hour of oral rehydration. Osmotic challenges were monitored by serum measures, including osmolality and hematocrit. With dehydration, serum osmolality increased by 0.67% and brain tissue fluid decreased by 1.63%. MR imaging morphometry demonstrated corresponding decreases of cortical thickness and volumes of the whole brain, cortex, white matter, and hypothalamus/thalamus. These changes reversed during rehydration. The authors conclude that it is essential to control for hydration levels in studies on brain morphometry and metabolism in order to avoid confounding the findings.

These authors retrospectively evaluated 12 patients with natalizumab–progressive multifocal leukoencephalopathy (PML), 5 with PML from other causes, and 55 patients with MS without progressive PML for comparison. They observed T2* or SWI signal abnormalities at the chronic stage in all patients with PML, but in patients without PML no areas of low SWI signal intensity were detected. PML—related to natalizumab or not—induces brain susceptibility changes within U-fibers or deep gray matter that are visible on T2* or SWI and potentially explained by iron deposition.

CTA images of the arterial and late arterial phases were used to obtain warped images of the late arterial phase by nonrigid registration that was adjusted to the arterial phase images. R-CTA images were then obtained by subtracting the warped images from the arterial phase images. R-CTA had a higher accuracy compared with conventional spinal CTA (80% versus 47%). The authors conclude that subtracted CTA imaging using nonrigid registration detects feeders of spinal arteriovenous fistulas more accurately and quickly than conventional CTA.

These authors retrospectively evaluated 12 patients with natalizumab–progressive multifocal leukoencephalopathy (PML), 5 with PML from other causes, and 55 patients with MS without progressive PML for comparison. They observed T2* or SWI signal abnormalities at the chronic stage in all patients with PML, but in patients without PML no areas of low SWI signal intensity were detected. PML—related to natalizumab or not—induces brain susceptibility changes within U-fibers or deep gray matter that are visible on T2* or SWI and potentially explained by iron deposition.

In this study of 793 patients with 906 aneurysms, 20 (2.5%) had intraparenchymal hemorrhage. Nine patients with intraparenchymal hemorrhage (45.0%) died, 10 (50.0%) had major neurologic morbidity, and 1 (5.0%) had minor neurologic morbidity. Variables associated with higher odds of intraparenchymal hemorrhage included treatment of ruptured aneurysms and the use of 3 or more Pipeline Embolization Devices. The Shuttle sheath was not associated with intraparenchymal hemorrhage.

These authors retrospectively evaluated 12 patients with natalizumab–progressive multifocal leukoencephalopathy (PML), 5 with PML from other causes, and 55 patients with MS without progressive PML for comparison. They observed T2* or SWI signal abnormalities at the chronic stage in all patients with PML, but in patients without PML no areas of low SWI signal intensity were detected. PML—related to natalizumab or not—induces brain susceptibility changes within U-fibers or deep gray matter that are visible on T2* or SWI and potentially explained by iron deposition.

CTA images of the arterial and late arterial phases were used to obtain warped images of the late arterial phase by nonrigid registration that was adjusted to the arterial phase images. R-CTA images were then obtained by subtracting the warped images from the arterial phase images. R-CTA had a higher accuracy compared with conventional spinal CTA (80% versus 47%). The authors conclude that subtracted CTA imaging using nonrigid registration detects feeders of spinal arteriovenous fistulas more accurately and quickly than conventional CTA.

CTA images of the arterial and late arterial phases were used to obtain warped images of the late arterial phase by nonrigid registration that was adjusted to the arterial phase images. R-CTA images were then obtained by subtracting the warped images from the arterial phase images. R-CTA had a higher accuracy compared with conventional spinal CTA (80% versus 47%). The authors conclude that subtracted CTA imaging using nonrigid registration detects feeders of spinal arteriovenous fistulas more accurately and quickly than conventional CTA.

Serial T1WI and ¹H-MR spectroscopy data were acquired in 15 healthy individuals at normohydration, at 12 hours of dehydration, and during 1 hour of oral rehydration. Osmotic challenges were monitored by serum measures, including osmolality and hematocrit. With dehydration, serum osmolality increased by 0.67% and brain tissue fluid decreased by 1.63%. MR imaging morphometry demonstrated corresponding decreases of cortical thickness and volumes of the whole brain, cortex, white matter, and hypothalamus/thalamus. These changes reversed during rehydration. The authors conclude that it is essential to control for hydration levels in studies on brain morphometry and metabolism in order to avoid confounding the findings.

These authors retrospectively evaluated 12 patients with natalizumab–progressive multifocal leukoencephalopathy (PML), 5 with PML from other causes, and 55 patients with MS without progressive PML for comparison. They observed T2* or SWI signal abnormalities at the chronic stage in all patients with PML, but in patients without PML no areas of low SWI signal intensity were detected. PML—related to natalizumab or not—induces brain susceptibility changes within U-fibers or deep gray matter that are visible on T2* or SWI and potentially explained by iron deposition.

CTA images of the arterial and late arterial phases were used to obtain warped images of the late arterial phase by nonrigid registration that was adjusted to the arterial phase images. R-CTA images were then obtained by subtracting the warped images from the arterial phase images. R-CTA had a higher accuracy compared with conventional spinal CTA (80% versus 47%). The authors conclude that subtracted CTA imaging using nonrigid registration detects feeders of spinal arteriovenous fistulas more accurately and quickly than conventional CTA.