Comparing 3T T1-Weighted Sequences in Identifying Hyperintense Punctate Lesions in Preterm Neonates

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Fig 1.
Schematic representation of a typical neonatal brain. Only the central (motor) location on the 1-mm reformatted T1 3D-FFE sequence scored a significantly greater number of HPLs compared with IR and SE sequences. The 1-mm axial reformatted T1 3D-FFE sequence identified a significant overall greater number of HPLs than other 3-mm sequences (P < .01).
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Fig 2.
Three-millimeter (A) and 1-mm (B) axial reformatted T1 3D-FFE sequences of PNs affected by PVL. The thinner sections (B) separated lesions that were seen as confluent with the thicker sections (A).

Table 1:

MRI sequence parameters

Sequence	Section Thickness (mm)	Intersection (mm)	TR (ms)	TE (ms)	TI (ms)	FA	SAR (W/Kg)	dB
Axial T1 SE	3	0.5	663	11	–	–	<0.2	−6.5
Axial T1 IR	3	0.5	4938	15	400	–	<0.1	7.2
T1 3D-FFE	1 and 3	0	9.2	4.3	–	10°	0.0	5.4
Axial T2-TSE	3	0.5	3000	80	–	–	<0.2	6.5
Axial DWI	4	1	2380	65	–	–	<0.1	9.5

Table 2:

HPLs identified in consensus reading

Patient	Sex	Outcome	Overall
Patient	Sex	Outcome	3-mm T1 FFE	1-mm T1 FFE	3-mm T1 IR	3-mm T1 SE
1	F	1	4	7	0	NA
2	F	0	3	7	0	NA
3	F	1	12	20	6	NA
4	F	0	3	8	6	NA
5	M	1	8	12	5	4
6	F	1	16	35	8	16
7	M	0	9	12	6	7
8	M	1	17	19	10	11
9	M	1	12	25	9	9
10	F	1	9	11	11	10
11	M	0	3	5	2	4
12	F	NA	5	14	7	4
13	M	1	6	9	11	11
14	M	1	21	30	9	9
15	M	1	15	29	17	15
16	M	1	6	13	8	14
17	M	NA	4	9	NA	NA
18	F	0	8	11	0	0
19	M	0	6	9	1	2
20	F	1	6	12	5	6
21	M	0	4	9	0	0
22	M	1	4	8	3	4
23	M	1	2	4	2	2
24	F	1	4	10	3	1
25	M	1	1	7	5	2
26	M	1	15	15	9	13
27	M	0	5	10	3	3
28	M	0	2	5	0	0
29	M	1	2	8	0	0
30	F	1	1	5	0	0
31	F	1	5	8	6	4
Total			218	386	152	151