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Research ArticleInterventional

Extra-Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel

G. Gascou, K. Lobotesis, H. Brunel, P. Machi, C. Riquelme, O. Eker, A. Bonafé and V. Costalat
American Journal of Neuroradiology April 2015, 36 (4) 725-731; DOI: https://doi.org/10.3174/ajnr.A4191
G. Gascou
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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K. Lobotesis
bDepartment of Imaging (K.L.), Imperial College Healthcare NHS Trust, Charing Cross Hospital, United Kingdom
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H. Brunel
cDepartment of Neuroradiology (H.B.), CHU La Timone, Marseille, France.
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P. Machi
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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C. Riquelme
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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O. Eker
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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A. Bonafé
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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V. Costalat
aFrom the Department of Neuroradiology (G.G., P.M., C.R., O.E., A.B., V.C.), CHU Gui de Chauliac, Montpellier, France
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  • Fig 1.
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    Fig 1.

    Perforator infarction following PED placement and arterial narrowing of the covered artery on a 12-month follow-up angiogram. A, Anteroposterior view shows the dissecting aneurysm of the left proximal M1 segment. B, Anteroposterior view after PED placement shows absence of filling of the aneurysm and slow flow within the A1 segment. The acquisition was performed with the same parameters but in a later phase to see the A1 segment. C, Single PED placement within the left M1 segment results in contrast stagnation within the aneurysm sac. D and E, DWI and FLAIR sequences performed 2 days later because of transient right brachiofacial hemiparesis demonstrate basal ganglial infarction. F, Twelve-month follow-up angiogram shows the ostial narrowing of the covered collateral branches (arrow).

  • Fig 2.
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    Fig 2.

    Slow flow within MCA side branch. A, Left MCA aneurysm treated with a PED covering the prefrontal branch. B and C, Slow flow within the covered side branch (arrows). D and E, MR imaging performed on day 1 after the procedure shows acute left anterior MCA infarct.

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    Fig 3.

    Imaging findings in a patient presenting with cerebral reperfusion syndrome. The patient was treated for a large left carotid cavernous aneurysm with the implantation of 2 overlapped PEDs (A). Seven hours after the procedure, the patient had severe headache and mild aphasia. B and C, FLAIR images show leptomeningeal hyperintensities in the left hemisphere (arrows) without evidence of hemorrhage on T2 gradient-echo (C). D, FLAIR performed 24 hours after the procedure shows complete reversibility of leptomeningeal hyperintensities.

Tables

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    Table 1:

    Baseline characteristics

    CharacteristicsValue%
    Patients59
    Age (mean, yr)53.7
    Female sex4678
    Aneurysms66
    Morphology
        Saccular4466.7
        Dissecting1624.2
        Blister23
        Fusiform46.1
    Size (mean, mm)10.7
    Size (maximum diameter)
        <10 mm (small)3857.6
        >10–25 mm (large)2334.8
        >25 mm (giant)57.6
    Neck ≥4 mm5075.8
    Dome-to-neck ratio <23654.5
    Location
    Anterior circulation5481.8
        CCA2537.9
        COA1624.2
        MCA710.6
        ACA23
        PcomA46.1
    Posterior circulation1218.2
        BA23
        VA710.7
        PCA23
        PICA11.5
    • Note:—CCA indicates cavernous carotid artery; COA, carotico-ophthalmic artery; BA, basilar artery; VA, vertebral artery; PcomA, posterior communicating artery; PCA, posterior cerebral artery; PICA, posterior inferior cerebellar artery.

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    Table 2:

    Hemodynamic modifications within visible side branches covered by the PED and consequences

    Side BranchesNo. of PEDs ImplantedNo. of Side BranchesSlow Flow within Side BranchesTransient or Permanent Neurologic DeficitsaTerritorial Ischemic Lesions on MRIStenosis at 12-Mo Follow-UpOcclusion at 12-Mo Follow-Up
    Ophthalmic artery12530NA21
    2510NA10
    3100NA01
    4310NA00
    Anterior choroidal artery11103000
    2100000
    ACA1553050
    Callosomarginal artery1100000
    MCA1532110
    PcomA1200000
    PICA1500020
    2100000
    SCA3100000
    PCA3100000
    Anterior spinal artery1100000
    Total6813 (19.1%)81112
    Perforators
        Sylvian perforators14NA31NANA
    21NA00NANA
        BA perforators31NA00NANA
    51NA00NANA
    Total7NA31NANA
    • Note:—SCA indicates superior cerebellar artery; NA, not available; BA, basilar artery; PcomA, posterior communicating artery; PCA, posterior cerebral artery; PICA, posterior inferior cerebellar artery.

    • ↵a Related to the side branch covered.

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American Journal of Neuroradiology: 36 (4)
American Journal of Neuroradiology
Vol. 36, Issue 4
1 Apr 2015
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Cite this article
G. Gascou, K. Lobotesis, H. Brunel, P. Machi, C. Riquelme, O. Eker, A. Bonafé, V. Costalat
Extra-Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel
American Journal of Neuroradiology Apr 2015, 36 (4) 725-731; DOI: 10.3174/ajnr.A4191

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Extra-Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel
G. Gascou, K. Lobotesis, H. Brunel, P. Machi, C. Riquelme, O. Eker, A. Bonafé, V. Costalat
American Journal of Neuroradiology Apr 2015, 36 (4) 725-731; DOI: 10.3174/ajnr.A4191
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