Quantitative Diffusion-Weighted MRI Parameters and Human Papillomavirus Status in Oropharyngeal Squamous Cell Carcinoma

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig 1.
Axial MR images of an HPV-positive OPSCC. A 48-year-old patient was diagnosed with an OPSCC in the right palatine tonsil. A, STIR MR image shows a hyperintense mass in the palatine tonsil (arrow). A b=750 diffusion-weighted image (B) and an ADC map (C) show decreased ADC. An ROI was drawn on the b=750 diffusion-weighted image and copied to the ADC map. In this ROI, ADC_minimum measured 0.992 × 10⁻³ mm²/s.
Download figure
Open in new tab
Download powerpoint
Fig 2.
Axial MR images of an HPV-negative OPSCC. A 54-year-old patient was diagnosed with an OPSCC in the right palatine tonsil. A, STIR MR image shows a large hyperintense mass in the oropharynx (arrow). A b=750 diffusion-weighted image (B) and an ADC map (C) show decreased ADC. An ROI was drawn on the b=750 diffusion-weighted image and copied to the ADC map. In this ROI, ADC_minimum measured 0.826 × 10⁻³ mm²/s.

Table 1:

General patient characteristics

Characteristic	HPV-Positive (n = 22) (50%)	HPV-Negative (n = 22) (50%)	P Value
Sex			.30
Male	18 (81.8%)	15 (68.2%)
Female	4 (18.2%)	7 (31.8%)
Age at diagnosis (yr)			.92
Median (range)	57 (47–78)	60.5 (45–71)
Oropharyngeal subsite			.29
Tonsil	12 (54.4%)	10 (45.5%)
Base of tongue	8 (36.4%)	6 (27.3%)
Oropharynx nos	2 (9.1%)	6 (27.3%)
Smoking^{^a}			.01
Never (0–5 pack years)	8 (36.4%)	0 (0%)
Moderate (6–24 pack years)	5 (22.7%)	5 (22.7%)
Heavy (>24 pack years)	9 (40.9%)	17 (77.3%)
Alcohol consumption^{^b}			.02
Never (0)	3 (13.6%)	0 (0%)
Moderate (1–149 U years)	15 (68.2%)	10 (45.5%)
Heavy (>149 U years)	4 (18.2%)	12 (54.5%)
T-stage			.03
T2	12 (54.5%)	5 (22.7%)
T3–4	10 (45.5%)	17 (77.3%)
N-stage			.04
N0	0 (0%)	5 (22.7%)
N1–3	22 (100%)	17 (77.3%)
M-stage			NA
M0	22 (100%)	22 (100%)
M1	0 (0%)	0 (0%)

Note:—NA indicates not applicable; Oropharynx nos, oropharynx not otherwise specified.
↵a Smoking was defined in pack years (1 pack year = 20 cigarettes a day during 1 year).
↵b Alcohol consumption was defined in unit years (1 U year = 1 alcohol-containing consumption a day during 1 year).