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Research ArticleBrain

Multimodal CT Provides Improved Performance for Lacunar Infarct Detection

T. Das, F. Settecase, M. Boulos, T. Huynh, C.D. d'Esterre, S.P. Symons, L. Zhang and R.I. Aviv
American Journal of Neuroradiology June 2015, 36 (6) 1069-1075; DOI: https://doi.org/10.3174/ajnr.A4255
T. Das
aFrom the Department of Radiology (T.D.), Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK
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F. Settecase
cDepartments of Medical Imaging (F.S., T.H., R.I.A., S.P.S., L.Z.)
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M. Boulos
dNeurology (M.B.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
eUniversity of Toronto (M.B., T.H., S.P.S., R.I.A.), Toronto, Ontario, Canada.
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T. Huynh
cDepartments of Medical Imaging (F.S., T.H., R.I.A., S.P.S., L.Z.)
eUniversity of Toronto (M.B., T.H., S.P.S., R.I.A.), Toronto, Ontario, Canada.
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C.D. d'Esterre
bDepartment of Neurology (C.D.d.), University of Calgary, Calgary Stroke Program, Foothills Medical Centre, Calgary, Alberta, Canada
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S.P. Symons
cDepartments of Medical Imaging (F.S., T.H., R.I.A., S.P.S., L.Z.)
eUniversity of Toronto (M.B., T.H., S.P.S., R.I.A.), Toronto, Ontario, Canada.
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L. Zhang
cDepartments of Medical Imaging (F.S., T.H., R.I.A., S.P.S., L.Z.)
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R.I. Aviv
cDepartments of Medical Imaging (F.S., T.H., R.I.A., S.P.S., L.Z.)
eUniversity of Toronto (M.B., T.H., S.P.S., R.I.A.), Toronto, Ontario, Canada.
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References

  1. 1.↵
    1. Kolominsky-Rabas PL,
    2. Weber M,
    3. Gefeller O, et al
    . Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 2001;32:2735–40
    Abstract/FREE Full Text
  2. 2.↵
    1. Wardlaw JM,
    2. Smith C,
    3. Dichgans M
    . Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol 2013;12:483–97
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Norrving B
    . Long-term prognosis after lacunar infarction. Lancet Neurol 2003;2:238–45
    CrossRefPubMedWeb of Science
  4. 4.↵
    National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581–87
    CrossRefPubMedWeb of Science
  5. 5.↵
    IST-3 collaborative group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third International Stroke Trial [IST-3]): a randomised controlled trial. Lancet 2012;379:2352–63
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Fuentes B,
    2. Martínez-Sánchez P,
    3. Alonso de Leciñana M, et al
    . Efficacy of intravenous thrombolysis according to stroke subtypes: the Madrid Stroke Network data. Eur J Neurol 2012;19:1568–74
    CrossRefPubMed
  7. 7.↵
    1. Pantoni L,
    2. Fierini F,
    3. Poggesi A
    . Thrombolysis in acute stroke patients with cerebral small vessel disease. Cerebrovasc Dis 2014;37:5–13
    CrossRefPubMed
  8. 8.↵
    1. Chalela JA,
    2. Ezzeddine M,
    3. Latour L, et al
    . Reversal of perfusion and diffusion abnormalities after intravenous thrombolysis for a lacunar infarction. J Neuroimaging 2003;13:152–54
    CrossRefPubMed
  9. 9.↵
    1. Wessels T,
    2. Röttger C,
    3. Jauss M, et al
    . Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes. Stroke 2005;36:757–61
    Abstract/FREE Full Text
  10. 10.↵
    1. Young KC,
    2. Benesch CG,
    3. Jahromi BS
    . Cost-effectiveness of multimodal CT for evaluating acute stroke. Neurology 2010;75:1678–85
    CrossRef
  11. 11.↵
    1. Hopyan J,
    2. Ciarallo A,
    3. Dowlatshahi D, et al
    . Certainty of stroke diagnosis: incremental benefit with CT perfusion over noncontrast CT and CT angiography. Radiology 2010;255:142–53
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Campbell BCV,
    2. Weir L,
    3. Desmond PM, et al
    . CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2013;84:613–18
    Abstract/FREE Full Text
  13. 13.↵
    1. Yamada M,
    2. Yoshimura S,
    3. Kaku Y, et al
    . Prediction of neurologic deterioration in patients with lacunar infarction in the territory of the lenticulostriate artery using perfusion CT. AJNR Am J Neuroradiol 2004;25:402–08
    Abstract/FREE Full Text
  14. 14.↵
    1. Poppe AY,
    2. Coutts SB,
    3. Kosior J, et al
    . Normal magnetic resonance perfusion-weighted imaging in lacunar infarcts predicts a low risk of early deterioration. Cerebrovasc Dis 2009;28:151–56
    CrossRefPubMed
  15. 15.↵
    1. Gerraty RP,
    2. Parsons MW,
    3. Barber PA, et al
    . Examining the lacunar hypothesis with diffusion and perfusion magnetic resonance imaging. Stroke 2002;33:2019–24
    Abstract/FREE Full Text
  16. 16.↵
    1. Fisher CM
    . Lacunes: small, deep cerebral infarcts. Neurology 1965;15:774–84
    CrossRef
  17. 17.↵
    1. Lansberg MG,
    2. Thijs VN,
    3. O'Brien MW, et al
    . Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke. AJNR Am J Neuroradiol 2001;22:637–44
    Abstract/FREE Full Text
  18. 18.↵
    1. Potter GM,
    2. Marlborough FJ,
    3. Wardlaw JM
    . Wide variation in definition, detection, and description of lacunar lesions on imaging. Stroke 2011;42:359–66
    Abstract/FREE Full Text
  19. 19.↵
    1. Doege CA,
    2. Kerskens CM,
    3. Romero BI, et al
    . Assessment of diffusion and perfusion deficits in patients with small subcortical ischemia. AJNR Am J Neuroradiol 2003;24:1355–63
    Abstract/FREE Full Text
  20. 20.↵
    1. Restrepo L,
    2. Jacobs MA,
    3. Barker PB, et al
    . Etiology of perfusion-diffusion magnetic resonance imaging mismatch patterns. J Neuroimaging 2005;15:254–60
    CrossRefPubMed
  21. 21.↵
    1. Brenner DJ,
    2. Hall EJ
    . Computed tomography: an increasing source of radiation exposure. N Engl J Med 2007;357:2277–84
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. DeLong ER,
    2. DeLong DM,
    3. Clarke-Pearson DL
    . Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988;44:837–45
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Zhou X-H,
    2. Obuchowski NA,
    3. McClish DK
    . Comparing the accuracy of two diagnostic tests. In: Statistical Methods in Diagnostic Medicine, 2nd ed. Hoboken: John Wiley & Sons; 2011:165–92
  24. 24.↵
    1. Barnhart HX,
    2. Williamson JM
    . Weighted least-squares approach for comparing correlated kappa. Biometrics 2002;58:1012–19
    CrossRefPubMed
  25. 25.↵
    1. Bezerra DC,
    2. Sharrett AR,
    3. Matsushita K, et al
    . Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) study. Neurology 2012;78:102–08
    CrossRef
  26. 26.↵
    1. Mohr JP,
    2. Caplan LR,
    3. Melski JW, et al
    . The Harvard Cooperative Stroke Registry: a prospective registry. Neurology 1978;28:754–62
    CrossRef
  27. 27.↵
    1. Nakamura K,
    2. Saku Y,
    3. Ibayashi S, et al
    . Progressive motor deficits in lacunar infarction. Neurology 1999;52:29–33
    CrossRef
  28. 28.↵
    1. Tei H,
    2. Uchiyama S,
    3. Ohara K, et al
    . Deteriorating ischemic stroke in 4 clinical categories classified by the Oxfordshire Community Stroke Project. Stroke 2000;31:2049–54
    Abstract/FREE Full Text
  29. 29.↵
    1. Shobha N,
    2. Fang J,
    3. Hill MD
    . Do lacunar strokes benefit from thrombolysis? Evidence from the registry of the Canadian Stroke Network. Int J Stroke 2013;8(suppl A100):45–49
    CrossRefPubMed
  30. 30.↵
    1. Mustanoja S,
    2. Meretoja A,
    3. Putaala J, et al
    . Outcome by stroke etiology in patients receiving thrombolytic treatment: descriptive subtype analysis. Stroke 2011;42:102–06
    Abstract/FREE Full Text
  31. 31.↵
    1. Lee SJ,
    2. Saver JL,
    3. Liebeskind DS, et al
    . Safety of intravenous fibrinolysis in imaging-confirmed single penetrator artery infarcts. Stroke 2010;41:2587–91
    Abstract/FREE Full Text
  32. 32.↵
    1. Murphy A,
    2. So A,
    3. Lee TY, et al
    . Low dose CT perfusion in acute ischemic stroke. Neuroradiology 2014;56:1055–62
    CrossRefPubMed
  33. 33.↵
    1. Wintermark M,
    2. Sanelli PC,
    3. Albers GW, et al
    . Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery. AJNR Am J Neuroradiol 2013;34:E117–27
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 36 (6)
American Journal of Neuroradiology
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Cite this article
T. Das, F. Settecase, M. Boulos, T. Huynh, C.D. d'Esterre, S.P. Symons, L. Zhang, R.I. Aviv
Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
American Journal of Neuroradiology Jun 2015, 36 (6) 1069-1075; DOI: 10.3174/ajnr.A4255

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Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
T. Das, F. Settecase, M. Boulos, T. Huynh, C.D. d'Esterre, S.P. Symons, L. Zhang, R.I. Aviv
American Journal of Neuroradiology Jun 2015, 36 (6) 1069-1075; DOI: 10.3174/ajnr.A4255
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