Statin Therapy Does Not Affect the Radiographic and Clinical Profile of Patients with TIA and Minor Stroke

Article Figures & Data

Table 1:

Baseline clinical and radiographic characteristics of patients based on prior statin treatment

Baseline Characteristics	Prior Statin (n = 96)	No Prior Statin (n = 322)	P Value
Age (yr) (median) (IQR)	73 (14)	66 (24)	<.001
Sex (% male)	68% (65/96)	58% (187/322)	.09
Smoking	15% (14/96)	15% (49/322)	.87
Hypertension (%)	73% (70/96)	50% (159/322)	<.001
Diabetes mellitus (%)	19% (18/96)	12% (39/322)	.044
Prior ASA treatment (%)	65% (62/96)	22% (71/322)	<.001
Symptomatic carotid disease^{^a}	19% (18/96)	7% (21/322)	.001
Symptomatic intracranial disease^{^b}	12% (11/96)	21% (67/322)	.174
Positive CTA finding^{^c}	31% (30/96)	27% (88/322)	.45
DWI-positive	64% (61/96)	55% (177/322)	.08
DWI infarct volume (mL) (median) (IQR)	1.0 (2.5)	1.1 (4)	.56

Note:—ASA indicates aspirin.
↵a Symptomatic carotid disease: extracranial carotid stenosis of ≥50%.
↵b Symptomatic intracranial disease: symptomatic intracranial vascular occlusion or stenosis of ≥50%.
↵c Positive CTA finding: relevant intra- or extracranial occlusion or stenosis of ≥50%.

Table 2:

Baseline clinical and radiographic characteristics stratified by statin treatment (statin therapy either continued or acutely started) or not

Baseline Characteristics	On Statin Treatment^{^a} (n = 251)	No Statin Treatment (n = 167)	P Value
Age (yr) (median) (IQR)	70 (18)	62 (25)	<.001
Hypertension (%)	63% (159/251)	42% (70/167)	<.001
Sex (% male)	65% (163/251)	53% (89/167)	.01
Smoking	17% (42/251)	13% (21/167)	.24
Diabetes mellitus (%)	15% (38/251)	11% (19/167)	.38
Symptomatic extracranial carotid disease ≥50% (%)	13% (33/251)	4% (6/167)	.001
Symptomatic intracranial vascular occlusion/stenosis ≥50% (%)	25% (63/251)	15% (25/167)	.013
Positive CTA finding^{^b}	36% (89/251)	17% (29/167)	<.001
DWI-positive on baseline MRI	69% (172/251)	40% (66/167)	<.001
DWI infarct volume (mL) (median) (IQR)	1.1 (3.8)	1.0 (2.9)	.48

↵a Statin treatment either acutely started or continued.
↵b Positive CTA finding: relevant intra- or extracranial occlusion or stenosis of ≥50%.