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Research ArticleBrain

Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis

O.T. Wiebenga, A.M. Klauser, M.M. Schoonheim, G.J.A. Nagtegaal, M.D. Steenwijk, J.A. van Rossum, C.H. Polman, F. Barkhof, P.J.W. Pouwels and J.J.G. Geurts
American Journal of Neuroradiology June 2015, 36 (6) 1116-1123; DOI: https://doi.org/10.3174/ajnr.A4252
O.T. Wiebenga
aFrom the Departments of Radiology and Nuclear Medicine (O.T.W., G.J.A.N.†, M.D.S., F.B.)
bAnatomy and Neurosciences (O.T.W., A.M.K., M.M.S., G.J.A.N.†, J.J.G.G.)
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A.M. Klauser
bAnatomy and Neurosciences (O.T.W., A.M.K., M.M.S., G.J.A.N.†, J.J.G.G.)
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M.M. Schoonheim
bAnatomy and Neurosciences (O.T.W., A.M.K., M.M.S., G.J.A.N.†, J.J.G.G.)
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G.J.A. Nagtegaal
aFrom the Departments of Radiology and Nuclear Medicine (O.T.W., G.J.A.N.†, M.D.S., F.B.)
bAnatomy and Neurosciences (O.T.W., A.M.K., M.M.S., G.J.A.N.†, J.J.G.G.)
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M.D. Steenwijk
aFrom the Departments of Radiology and Nuclear Medicine (O.T.W., G.J.A.N.†, M.D.S., F.B.)
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J.A. van Rossum
cNeurology (J.A.v.R., C.H.P.)
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C.H. Polman
cNeurology (J.A.v.R., C.H.P.)
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F. Barkhof
aFrom the Departments of Radiology and Nuclear Medicine (O.T.W., G.J.A.N.†, M.D.S., F.B.)
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P.J.W. Pouwels
dPhysics and Medical Technology (P.J.W.P.), Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, the Netherlands.
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J.J.G. Geurts
bAnatomy and Neurosciences (O.T.W., A.M.K., M.M.S., G.J.A.N.†, J.J.G.G.)
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American Journal of Neuroradiology: 36 (6)
American Journal of Neuroradiology
Vol. 36, Issue 6
1 Jun 2015
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Cite this article
O.T. Wiebenga, A.M. Klauser, M.M. Schoonheim, G.J.A. Nagtegaal, M.D. Steenwijk, J.A. van Rossum, C.H. Polman, F. Barkhof, P.J.W. Pouwels, J.J.G. Geurts
Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
American Journal of Neuroradiology Jun 2015, 36 (6) 1116-1123; DOI: 10.3174/ajnr.A4252

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Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
O.T. Wiebenga, A.M. Klauser, M.M. Schoonheim, G.J.A. Nagtegaal, M.D. Steenwijk, J.A. van Rossum, C.H. Polman, F. Barkhof, P.J.W. Pouwels, J.J.G. Geurts
American Journal of Neuroradiology Jun 2015, 36 (6) 1116-1123; DOI: 10.3174/ajnr.A4252
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  • Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the Translation From Proton Signal to Diagnostic Biomarker
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  • Exploring potential mechanisms of action of natalizumab in secondary progressive multiple sclerosis
    Finn Sellebjerg, Diego Cadavid, Deborah Steiner, Luisa Maria Villar, Richard Reynolds, Daniel Mikol
    Therapeutic Advances in Neurological Disorders 2016 9 1
  • Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System
    Kim M. A. De Kleijn, Gerard J. M. Martens
    International Journal of Molecular Sciences 2020 21 12
  • Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives
    Maria A. Rocca, Paolo Preziosa, Massimo Filippi
    Expert Review of Neurotherapeutics 2019 19 9
  • Occurrence and microstructural features of slowly expanding lesions on fingolimod or natalizumab treatment in multiple sclerosis
    Paolo Preziosa, Elisabetta Pagani, Lucia Moiola, Mariaemma Rodegher, Massimo Filippi, Maria A Rocca
    Multiple Sclerosis Journal 2021 27 10
  • The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials
    Kedar R. Mahajan, Daniel Ontaneda
    Neurotherapeutics 2017 14 4
  • Metabolites predict lesion formation and severity in relapsing-remitting multiple sclerosis
    Antoine M Klauser, Oliver T Wiebenga, Anand JC Eijlers, Menno M Schoonheim, Bernard MJ Uitdehaag, Frederik Barkhof, Petra JW Pouwels, Jeroen JG Geurts
    Multiple Sclerosis Journal 2018 24 4
  • Natalizumab for Multiple Sclerosis: A Case in Point for the Impact of Translational Neuroimmunology
    Afsaneh Shirani, Olaf Stüve
    The Journal of Immunology 2017 198 4
  • Grey matter atrophy is associated with disability increase in natalizumab-treated patients
    Ethel Ciampi, Deborah Pareto, Jaume Sastre-Garriga, Angela Vidal-Jordana, Carmen Tur, Jordi Río, Mar Tintoré, Cristina Auger, Alex Rovira, Xavier Montalban
    Multiple Sclerosis Journal 2017 23 4
  • Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady‐state metabolism and its relationship to conventional imaging
    Ivan I. Kirov, Shu Liu, Assaf Tal, William E. Wu, Matthew S. Davitz, James S. Babb, Henry Rusinek, Joseph Herbert, Oded Gonen
    Human Brain Mapping 2017 38 8

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