Article Figures & Data
Figures
- Fig 1.
Progressive brain atrophy in CLN2 disease. Baseline 3D-T1-weighted MPRAGE images in axial, coronal, and sagittal planes (left to right) of patient 457–1 (A), segmented brain volumes (B), and segmented brain volumes 4 years later (C).
- Fig 2.
Age dependence of segmented brain volumes, logarithmic fit functions, and confidence intervals.
Tables
- Table 1:
Correlation of brain volumes with patient age and clinical motor-language-visual scores
Patient Age Clinical Score Correlation Coefficient r P Valuea Correlation Coefficient r P Valuea ROI Lateral ventricles 0.606 .001 −0.692 <.001 Supratentorial cortical GM −0.913 <.001 0.862 <.001 Supratentorial WM −0.865 <.001 0.735 <.001 Basal ganglia/thalamus −0.832 <.001 0.758 <.001 Cerebellar GM −0.659 <.001 0.609 .001 Cerebellar WM −0.830 <.001 0.638 <.001 Clinical score −0.781 <.001 NA Note:—NA indicates not applicable.
↵a All P values are statistically significant.
- Table 2:
Correlation of brain volumes with patient age and clinical motor-language-visual scores for patients with very low clinical scores (<1)
Patient Age Clinical Scores <1 Correlation Coefficient r P Value Correlation Coefficient r P Value ROI Lateral ventricles −0.068 .810 NA NA Supratentorial cortical GM −0.903 <.001a NA NA Supratentorial WM 0.111 .695 NA NA Basal ganglia/thalamus −0.822 <.001a NA NA Cerebellar GM −0.548 .035a NA NA Cerebellar WM −0.795 <.001a NA NA Clinical score NA NA NA NA Note:—NA indicates not applicable.
↵a Statistically significant.
