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Research ArticlePEDIATRICS

Evaluation of Subependymal Gray Matter Heterotopias on Fetal MRI

U.D. Nagaraj, J.L. Peiro, K.S. Bierbrauer and B.M. Kline-Fath
American Journal of Neuroradiology April 2016, 37 (4) 720-725; DOI: https://doi.org/10.3174/ajnr.A4585
U.D. Nagaraj
aFrom the Departments of Radiology and Medical Imaging (U.D.N., B.M.K.-F)
dUniversity of Cincinnati College of Medicine (U.D.N., J.L.P., K.S.B., B.M.K.-F), Cincinnati, Ohio.
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J.L. Peiro
bPediatric Surgery (J.L.P.)
dUniversity of Cincinnati College of Medicine (U.D.N., J.L.P., K.S.B., B.M.K.-F), Cincinnati, Ohio.
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K.S. Bierbrauer
cPediatric Neurosurgery (K.S.B.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
dUniversity of Cincinnati College of Medicine (U.D.N., J.L.P., K.S.B., B.M.K.-F), Cincinnati, Ohio.
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B.M. Kline-Fath
aFrom the Departments of Radiology and Medical Imaging (U.D.N., B.M.K.-F)
dUniversity of Cincinnati College of Medicine (U.D.N., J.L.P., K.S.B., B.M.K.-F), Cincinnati, Ohio.
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    Fig 1.

    Breakdown of the fetuses included in our study. OEIS indicates omphalocele-exstrophy-imperforate anus-spinal defects.

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    Fig 2.

    Example of SEH prospectively diagnosed on fetal MR imaging (true-positive finding). Axial T2 single-shot fast spin-echo imaging of the fetal brain at 25 weeks' GA (A) demonstrates multiple nodules along the ependymal surfaces of the lateral ventricles suspicious for SEH. Postnatal brain MR imaging at 5 weeks of age (B) confirms the presence of bilateral SEH on axial T2 FSE.

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    Fig 3.

    An example of subependymal nodularity giving the false appearance of SEH (false-positive finding). Axial T2 single-shot fast spin-echo image from fetal MR imaging at 24 weeks' GA (A) demonstrates nodularity along the ependymal surfaces of the lateral ventricles, giving the appearance of SEH. However, postnatal MR imaging at 8 weeks of age (B) does not demonstrate any SEH.

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    Fig 4.

    Example of a false-negative finding in a patient with SEH. Postnatal brain MR imaging at 15 days of age (A) demonstrates 2 small SEH along the right lateral ventricle (arrow) on axial T2 FSE imaging. In retrospect, there is some subtle asymmetric irregularity of the subependyma (arrow) on fetal MR imaging at 24 weeks' GA (B) on axial T2 single-shot fast spin-echo imaging. However, other areas of nodularity on fetal MR imaging in this patient (C, arrows) do not correspond to SEH postnatally (D).

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American Journal of Neuroradiology: 37 (4)
American Journal of Neuroradiology
Vol. 37, Issue 4
1 Apr 2016
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Cite this article
U.D. Nagaraj, J.L. Peiro, K.S. Bierbrauer, B.M. Kline-Fath
Evaluation of Subependymal Gray Matter Heterotopias on Fetal MRI
American Journal of Neuroradiology Apr 2016, 37 (4) 720-725; DOI: 10.3174/ajnr.A4585

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Evaluation of Subependymal Gray Matter Heterotopias on Fetal MRI
U.D. Nagaraj, J.L. Peiro, K.S. Bierbrauer, B.M. Kline-Fath
American Journal of Neuroradiology Apr 2016, 37 (4) 720-725; DOI: 10.3174/ajnr.A4585
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