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Research ArticleExtracranial Vascular
Open Access

Association between Carotid Plaque Features on CTA and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis

H. Baradaran, K. Al-Dasuqi, A. Knight-Greenfield, A. Giambrone, D. Delgado, E.J. Ebani, H. Kamel and A. Gupta
American Journal of Neuroradiology December 2017, 38 (12) 2321-2326; DOI: https://doi.org/10.3174/ajnr.A5436
H. Baradaran
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
bClinical and Translational Neuroscience Unit (H.B., H.K., A.G.)
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  • ORCID record for H. Baradaran
K. Al-Dasuqi
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
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A. Knight-Greenfield
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
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  • ORCID record for A. Knight-Greenfield
A. Giambrone
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
bClinical and Translational Neuroscience Unit (H.B., H.K., A.G.)
cFeil Family Brain and Mind Research Institute (H.K., A.G.)
dDepartment of Healthcare Policy and Research (A.G.)
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D. Delgado
eSamuel J. Wood Library and C.V. Starr Biomedical Information Center (D.D.)
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  • ORCID record for D. Delgado
E.J. Ebani
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
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H. Kamel
bClinical and Translational Neuroscience Unit (H.B., H.K., A.G.)
cFeil Family Brain and Mind Research Institute (H.K., A.G.)
fDepartment of Neurology (H.K.), Weill Cornell Medicine, New York, New York.
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A. Gupta
aFrom the Department of Radiology (H.B., K.A.-D., A.K.-G., E.J.E., A.G.)
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    Fig 1.

    Four separate forest plots of the association between CT angiography–determined plaque characteristics and recent prior ipsilateral ischemic events. Each meta-analysis was calculated with a random-effects model with pooled ORs shown for each forest plot. Each square represents the point estimate of the effect size of the study with the square size being proportional to the inverse of the variance of the estimate and the horizontal lines representing each the 95% CI of each study. The diamond represents the pooled estimate with the width of the diamond representing the pooled 95% CI.

Tables

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  • Heterogeneity and publication bias measures

    Measures of HeterogeneityPublication Bias
    I2Cochran QP ValueKendall TP Value
    Soft-plaque studies76.3%21.13.0010.47.27
    Calcified-plaque studies19.8%7.49.280.14.56
    Plaque ulceration studies61.1%20.56.0080.389.018
    Carotid artery wall thickness studies34.6%1.52.22NANA
    • Note:—NA indicates not applicable.

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American Journal of Neuroradiology: 38 (12)
American Journal of Neuroradiology
Vol. 38, Issue 12
1 Dec 2017
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Cite this article
H. Baradaran, K. Al-Dasuqi, A. Knight-Greenfield, A. Giambrone, D. Delgado, E.J. Ebani, H. Kamel, A. Gupta
Association between Carotid Plaque Features on CTA and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis
American Journal of Neuroradiology Dec 2017, 38 (12) 2321-2326; DOI: 10.3174/ajnr.A5436

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Association between Carotid Plaque Features on CTA and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis
H. Baradaran, K. Al-Dasuqi, A. Knight-Greenfield, A. Giambrone, D. Delgado, E.J. Ebani, H. Kamel, A. Gupta
American Journal of Neuroradiology Dec 2017, 38 (12) 2321-2326; DOI: 10.3174/ajnr.A5436
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