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Research ArticleINTERVENTIONAL

Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study

L. Pierot, I. Gubucz, J.H. Buhk, M. Holtmannspötter, D. Herbreteau, L. Stockx, L. Spelle, J. Berkefeld, A.-C. Januel, A. Molyneux, J.V. Byrne, J. Fiehler, I. Szikora and X. Barreau
American Journal of Neuroradiology June 2017, 38 (6) 1151-1155; DOI: https://doi.org/10.3174/ajnr.A5178
L. Pierot
aFrom the Department of Neuroradiology (L.P.), Hôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France
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I. Gubucz
bNational Institute of Clinical Neurosciences (I.G., I.S.), Budapest, Hungary
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J.H. Buhk
cDepartment of Neuroradiology (J.H.B., J.F.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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M. Holtmannspötter
dRigshospitalet (M.H.), Copenhagen, Denmark
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D. Herbreteau
eCentre Hospitalier Universitaire Tours (D.H.), Tours, France
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L. Stockx
fZiekenhuis Oost-Limburg Genk (L. Stockx), Genk, Belgium
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L. Spelle
gHôpital Bicêtre (L. Spelle), Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France
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J. Berkefeld
hInstitut für Neuroradiologie (J.B.), Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt, Germany
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A.-C. Januel
iCentre Hospitalier Universitaire Toulouse (A.-C.J.), Toulouse, France
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A. Molyneux
jOxford Neurovascular and Neuroradiology Research Unit (J.V.B., A.M.), John Radcliffe Hospital, Oxford, UK
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J.V. Byrne
jOxford Neurovascular and Neuroradiology Research Unit (J.V.B., A.M.), John Radcliffe Hospital, Oxford, UK
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J. Fiehler
cDepartment of Neuroradiology (J.H.B., J.F.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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I. Szikora
bNational Institute of Clinical Neurosciences (I.G., I.S.), Budapest, Hungary
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X. Barreau
kCentre Hospitalier Universitaire Bordeaux (X.B.), Bordeaux, France.
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Abstract

BACKGROUND AND PURPOSE: Flow disruption with the Woven EndoBridge (WEB) device is an innovative technique for the endovascular treatment of wide-neck bifurcation aneurysms. The initial version of the device (WEB Double-Layer) was evaluated in the WEB Clinical Assessment of IntraSaccular Aneurysm Therapy (WEBCAST) study, whereas the French Observatory study evaluated both WEB Double-Layer and Single-Layer versions of the device. WEBCAST 2 was designed to evaluate the WEB Single-Layer with Enhanced Visualization.

MATERIALS AND METHODS: Patients with wide-neck bifurcation aneurysms for which WEB treatment was possible were included. Clinical data including adverse events and clinical status at 1 month and 1 year were collected and analyzed. A core laboratory evaluated anatomic results at 1 year following the procedure.

RESULTS: Ten European neurointerventional centers included 55 patients (38 women; 27–77 years of age; mean, 54.4 ± 10.0 years) with 55 aneurysms. Aneurysm locations were the middle cerebral artery in 25 aneurysms (45.5%), the anterior communicating artery in 16 (29.1%), the basilar artery in 9 (16.4%), and the internal carotid artery terminus in 5 (9.1%). Procedural morbidity and mortality at 1 month were, respectively, 1.8% (1/55 patients) and 0.0% (0/55 patients). Morbidity and mortality at 1 year were, respectively, 3.9% (2/51 patients) and 2.0% (1/51 patients). At 1 year, complete occlusion was observed in 27/50 aneurysms (54.0%); neck remnant, in 13/50 (26.0%); and aneurysm remnant, in 10/50 (20.0%) (adequate occlusion in 40/50, 80.0%).

CONCLUSIONS: WEBCAST 2 confirms the high safety and efficacy of WEB aneurysm treatment demonstrated in the WEBCAST and French Observatory studies.

ABBREVIATIONS:

EV
Enhanced Visualization
WEB
Woven EndoBridge
WEBCAST
WEB Clinical Assessment of IntraSaccular Aneurysm Therapy
WEB-DL
WEB Double-Layer
WEB-SL
WEB Single-Layer
WEB-SLS
Single-Layer Spherical

Endovascular treatment is now the first-line treatment for ruptured aneurysms.1 For unruptured aneurysms, no randomized trial has been completed that permits the direct comparison of clipping with endovascular treatment. However, at least in Europe, the tendency is to give priority to endovascular treatment.2 Some aneurysms, especially those with a wide-neck, are difficult to treat due to the challenges of stabilizing coils inside the aneurysm sac and avoiding their protrusion into the parent artery. Thus, more complex endovascular techniques have been developed, such as balloon-assisted coiling, stent-assisted coiling, and flow diversion.3⇓⇓⇓⇓–8

Flow disruption is now a well-established procedure for the treatment of wide-neck bifurcation aneurysms.9⇓⇓⇓–13 Today, it is also used in narrow-neck aneurysms and sidewall aneurysms.14 The therapy involves the placement of an intrasaccular device that alters the flow inside the aneurysm, inducing intrasaccular thrombosis. Introduced in 2010 in Europe, the Woven EndoBridge (WEB; Sequent Medical, Aliso Viejo, California) is the only intrasaccular device that has been extensively evaluated in the literature with several single- and multicenter, retrospective, and prospective series.9⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓–21 Good Clinical Practice studies, including the WEB Clinical Assessment of IntraSaccular Aneurysm Therapy (WEBCAST) and the French Observatory studies, have shown a high level of safety with the device.15⇓⇓–18 Efficacy has to be further evaluated, but 1-year anatomic results in both the WEBCAST and French Observatory studies are encouraging. However, important changes in the device have been introduced across the time, moving from a dual-layer, larger profile version (WEB-DL) to single-layer, lower profile versions (WEB-SL and WEB Single-Layer Spherical [SLS]) and more recently Single-Layer with Enhanced Visualization (EV) obtained by introducing composite wires of nitinol and platinum in the braid itself.

The WEBCAST study evaluated the WEB-DL, whereas the French Observatory evaluated the WEB-DL, WEB-SL, and the WEB-SLS.15⇓⇓–18 In the continuing effort to assess the clinical and anatomic performance of these new devices, it was logical to further evaluate this technique with a series of patients treated exclusively with single-layer (SL, SLS) and Enhanced Visualization devices.

Materials and Methods

WEBCAST 2 is a prospective, consecutive, multicenter, European registry dedicated to the evaluation of WEB-SL EV and WEB-SLS EV treatment for bifurcation aneurysms.

The study received national regulatory authorization (Advisory Committee on Information Processing in Material Research in the Field of Health), Reims Institutional Review Board approval, and National Commission for Data Processing and Freedom approval. Written informed consent was obtained for all patients.

Trial Design and Procedural Modalities

WEBCAST 2 protocol was similar to that in WEBCAST with some amendments.17 Inclusion criteria were ruptured (Hunt and Hess 1, 2, or 3) and unruptured bifurcation aneurysms located in the basilar artery, middle cerebral artery, anterior communicating artery, posterior communicating artery, and internal carotid artery terminus. The indication for endovascular treatment was determined in each center by a local multidisciplinary team that included neurosurgeons and neuroradiologists. The selection of aneurysms treated with the WEB device was performed autonomously in each center by the interventional neuroradiologists according to aneurysm characteristics (aneurysm status, aneurysm location and size, and neck size).

The treatment of aneurysms with the WEB was performed by using techniques similar to those used in the treatment of aneurysms with coils. The study protocol did not specify the antiplatelet regimen to be followed, and it was managed in each center as indicated for typical endovascular treatment with coils or stents and coils. Triaxial access was recommended. A very careful sizing of the aneurysm was recommended because previous evaluation showed that oversizing of the device plays an important role in the quality of anatomic results. On the basis of the size of the WEB device to be used, VIA-21 (WEB SL/SLS 4–7 mm), VIA-27 (WEB SL/SLS 8–9 mm), and VIA-33 (WEB SL/SLS 1011 mm) microcatheters (Sequent Medical) were used to catheterize the aneurysm. If the treatment plan included use of ancillary implant devices, the patient was not enrolled in the study. Treatment with ancillary devices (coils, stent, flow diverters) was allowed during the procedure if deemed necessary by the physician and was not considered a treatment failure.

Data Collection

The following data were collected for each patient: age and sex; aneurysm rupture status; aneurysm characteristics including location, size, and neck size; date of the procedure; perioperative antiplatelet medications; occurrence of complications during or after the procedure; and use of additional devices during the procedure (coils, remodeling balloons, stents, or flow diverters). The preoperative Hunt and Hess grade was collected in case of ruptured aneurysms. The modified Rankin Scale score was collected before treatment (unruptured aneurysms) and at 30 ± 7 days and 12 ± 3 months for all patients. Vascular imaging at 12 ± 3 months was collected.

Data Analysis

Clinical data were independently monitored and analyzed, including all adverse events. Morbidity was defined as mRS > 2 if preoperative mRS was ≤2 (or in case of ruptured aneurysm), or an increase of 1 point when the preoperative mRS was >2.

An expert interventional neuroradiologist (J.B.) independently evaluated aneurysm measurements and occlusion by using a 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant. According to a previous publication, opacification of the proximal recess of the WEB device was considered complete occlusion.15

Statistical Analysis

Continuous variables were described as mean ± SD. Categoric data were described numerically as a categoric total and as a percentage of the population analyzed. Binomial data were described as a ratio of the true value and the population analyzed. Confidence intervals for binomial data were calculated by the Clopper-Pearson method, and P values were calculated by the Fisher exact test. Analyses were conducted by using SPSS statistical software (IBM, Armonk, New York) for confidence intervals and P values.

Results

Patient and Aneurysm Population

Between August 2014 and May 2015, 10 European centers included 55 patients (38 women, 69.1%; 27–77 years of age; mean, 54.4 ± 10.0 years) with 55 aneurysms.

Four (7.3%) aneurysms were ruptured, and 51 (92.7%), unruptured. In patients with ruptured aneurysms, the Hunt and Hess grade was 1 in 1 patient and 3 in 3 patients. For patients treated for unruptured aneurysms, the preoperative mRS was 0 in 39/51 patients (76.5%), 1 in 10/51 patients (19.6%), 2 in 1/51 patients (2.0%), and 4 in 1/51 patients (2.0%). Aneurysm locations were the MCA in 25 aneurysms (45.5%), the anterior communicating artery in 16 (29.1%), the basilar artery in 9 (16.4%), and the ICA terminus in 5 (9.1%). The aneurysm neck was between 2.5 and 8.0 mm (mean, 4.6 ± 1.1 mm). The aneurysm neck was ≥4 mm in 41/55 aneurysms (74.5%). Aneurysm size was between 2.8 and 17.0 mm (mean, 6.7 ± 2.3 mm). The aneurysm was ≥10 mm in 3/55 aneurysms (5.5%).

Modalities of antiplatelet treatment before, during, and after the procedure are described in Table 1.

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Table 1:

Antiplatelet treatment before, during, and after WEB procedure

Treatment Feasibility, Adjunctive Treatments, and Adverse Events

Treatment was successfully performed in all except 2 patients (96.4%), with the WEB-SL in 47/53 patients and the WEB-SLS in 6/53 patients.

An adjunctive device (flow diverter and stent) was used in 1/53 aneurysms (1.9%).

Intraoperative thromboembolic events were reported in 8 patients (8/55, 14.5%). Four of these 8 patients had 1 antiplatelet agent, and 4 had 2 antiplatelet agents before the complication. There was no clinical worsening in 2 patients (3.6%), a transient deficit in 3 patients (5.4%), and a permanent deficit in 3 patients (5.4%). These 3 patients had a 1-month mRS of, respectively, 1, 2, and 3.

Another thromboembolic event was reported 5 months postprocedure, related to a concurrent condition (history of stroke). The patient had dual antiplatelet treatment before and after the procedure. The patient had a small cerebral infarct, which was not associated with a permanent deficit.

Intraoperative rupture was reported in 1/55 patients (1.8%) and was not symptomatic.

Mortality/Morbidity at 1 Month

At 30 days, all patients enrolled in the study had a clinical evaluation with mRS scoring. There was no mortality at 1 month. Procedural morbidity was observed in 1/55 patients (1.8%) related to a thromboembolic event (mRS 3). One patient (1.8%) with a ruptured aneurysm was mRS 4 at 1 month due to the initial bleeding. Global morbidity at 1 month was 3.6% (2/55).

Mortality/Morbidity at 1 Year

At 12 months, 51 of the 55 patients enrolled in the study were clinically evaluated with mRS scoring. Four patients were not included in the 1 year mortality/morbidity analysis (2 patients not treated with the WEB, 1 patient lost for follow-up, and 1 patient withdrawing his consent before 12-month follow-up).

One patient died between 1 month and 1 year follow-up: This patient had a huge retroperitoneal hematoma after the WEB procedure, further associated with intensive care complications (cardiac and respiratory). Mortality at 1 year was 1/51 (2.0%). Among the 2 patients who had mRS > 2 at 1 month, the patient with the initial ruptured aneurysm improved at 1 year (mRS 2). The patient with a TE event due to the procedure was still mRS 3 at 1 year. Another patient retreated at 14 months with a flow diverter had a thromboembolic complication with mRS 3 at discharge. Global morbidity at 1 year was 2/51 (3.9%).

Retreatment

Of the 53 aneurysms treated with the WEB, aneurysm occlusion and retreatment were not evaluated in 3 patients at 1 year: One patient died, 1 patient withdrew consent, and follow-up was missing for 1 patient. During the 12 ± 3 months' follow-up period, 4/50 aneurysms (8.0%) were retreated or had an attempted retreatment (Table 2). In all 4 cases, aneurysm remnants were detected at 6 months. In 1 patient, additional treatment by clipping was attempted 8 months after the initial procedure. Clipping was unsuccessful, and the patient had hemiplegia immediately after the procedure. Neurologic improvement was rapid, and the patient was mRS 2 at 1 year. This aneurysm was successfully retreated with the WEB SLS at 14 months. In another case, retreatment with Y-stent placement and coiling took place 10 months after the initial treatment.

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Table 2:

Retreatment completed 12 ± 3 months

In the 2 other cases, aneurysm retreatment took place after the 1-year DSA showed that the aneurysm remnant remained. Retreatment was performed in these 2 patients at 14 months. One was successfully retreated with Y-stent placement and coiling, and 1 patient was treated with a flow diverter. For this last patient, an intrastent thrombosis occurred during the procedure and the flow diverter was removed. The patient had clinical worsening with mRS 3 at discharge.

Anatomic Results at 1 Year

The vascular imaging technique was digital subtraction angiography in 39/50 patients (78.0%), MRA in 10 patients (20.0%), and CTA in 1 patient (2.0%).

Complete occlusion was observed in 27/50 aneurysms (54.0%); neck remnant, in 13/50 aneurysms (26.0%); and aneurysm remnant, in 10/50 aneurysms (20.0%). Adequate occlusion (complete occlusion or neck remnant) was observed in 40/50 aneurysms (80.0%).

Discussion

The rapid technologic evolution of the WEB device (Single-Layer, Enhanced Visualization) makes it necessary to have a proper evaluation of the latest generation of devices. In continuity with previously published WEB Good Clinical Practice studies (WEBCAST, French Observatory) and in parallel with ongoing Good Clinical Practice studies (WEB- Intrasaccular Therapy Study under FDA investigational device exemption in the United States, and CLinical Assessment of WEB Device in Ruptured aneurYSms [CLARITY] in Europe), WEBCAST 2 was designed according to the same protocol as WEBCAST to evaluate the WEB-SL with Enhanced Visualization in wide-neck bifurcation aneurysms.17 However, recent reports have outlined the possibility of using the WEB in other indications, including sidewall and narrow-neck aneurysms not included in WEBCAST 2.14

The results of WEBCAST 2 confirm that WEB treatment, with lower profile devices and smaller inner diameter microcatheters, is highly feasible, with a technical success rate of 96.4%, similar to that observed in the WEBCAST (94.1%) and the French Observatory (98.4%) studies.16,17 All patients in WEBCAST were treated with the WEB-DL, and in the French Observatory, 31/63 aneurysms were treated with the WEB-DL, with the remaining aneurysms treated with the WEB-SL or -SLS (most without the EV materials). Of note, the feasibility rate is not higher in WEBCAST 2 than in WEBCAST, given that the WEB-SL and SLS were thought to be easier to navigate and deploy. In fact, the selection of patients and aneurysms for WEB treatment was different in WEBCAST and WEBCAST 2 as illustrated by the higher percentage of anterior communicating artery aneurysms treated in WEBCAST 2 (29.1%) compared with WEBCAST (7.8%). A similar difference in patient/aneurysm selection when treating with the WEB-DL and WEB-SL and SLS was also observed in the French Observatory study.15,16

WEBCAST 2 confirms the high safety of aneurysm treatment with the WEB observed in the WEBCAST study. Morbidity and mortality at 1 month were very similar at 2.0% and 0.0%, respectively.17 Similar results were also reported in the French Observatory with 1-month morbidity at 3.2% and mortality at 0.0%.15,16 Moreover, morbidity and mortality at 1 month were not different in the DL and SL/SLS groups.

Efficacy as evaluated with anatomic results at 1-year is as good in WEBCAST 2 as in the WEBCAST (at 6 months) and French Observatory studies. Adequate occlusion was observed in 80.0% in WEBCAST 2, 85.4% in WEBCAST, and 79.3% in French Observatory.16,17 This result is quite important because it means that the new braiding of the single-layer devices provides a low-porosity equivalent, at least in term of anatomic results, to the previous braiding placed in 2 layers at the level of the neck. The new braiding decreases the porosity and provides a single-layer device that is less rigid than a dual-layer one, and easier to navigate, without worsening its efficacy. Also, the single-layer device has permitted a reduction in the size of the microcatheter used for delivery and deployment.

Finally, the retreatment rate is similar to that reported in the cumulative population of the WEBCAST and French Observatory studies, in which the retreatment rate was 6.4%, including retreatment effectively performed (3.6%), failed retreatment (0.9%), and planned retreatment (1.8%). In WEBCAST 2, retreatment was performed in 2 patients when the WEB device was not oversized (as currently recommended) and in 1 patient with a giant partially thrombosed aneurysm. A recent, single-center series showed that adequate occlusion was more frequent (but not significantly so) when the WEB device was appropriately sized (92.9%) than undersized (70.0%).22 In WEBCAST 2, two patients were retreated as a consequence of WEB undersizing; this scenario must be avoided.

Compared with alternative therapeutics, the safety of aneurysms treatment with the WEB-SL is similar to that of coiling. In CLARITY (ruptured aneurysms) and Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms (ATENA) (unruptured aneurysms), intraoperative rupture occurred in 3.7% and 2.6%, respectively, and thromboembolic events, in 13.3% and 7.1%, respectively.1,2 In ATENA, morbidity and mortality rates at 1 month were 1.7% and 1.4%, respectively, whereas in CLARITY, treatment morbidity and mortality were 3.7% and 1.5%, respectively. Comparison with surgical series is more difficult because the rate of thromboembolic events and intraoperative rupture is rarely reported, possibly because it is less frequent or underestimated.23 When we looked at the morbidity/mortality, in the largest meta-analysis dealing with unruptured aneurysms treated by clipping, the rate of death (1.7%) was higher compared with that in WEBCAST 2 (0.0%) and the rate of unfavorable outcome at 1 year was 6.7% compared with 5.9% in WEBCAST 2.23 The same meta-analysis showed interesting results regarding the efficacy of clipping. In 82.2% of all clipped aneurysms, the postoperative aneurysm occlusion rate was not reported. When it was reported, it was not independently evaluated (unlike the entire series of Good Clinical Practice WEB studies). When reported, complete occlusion was 91.8% (neck remnant in 3.9% and aneurysm remnant in 4.3%). There are no data on long-term follow-up.

This study has several limitations. First, the population was relatively small (55 patients). However, it is the first prospective, multicenter study evaluating the safety and efficacy of aneurysm treatment with WEB-SL and WEB-SLS devices with independent assessment of adverse events and anatomic results. Second, it is not a randomized study, and comparison with other techniques is not easy. However, safety data are excellent and quite comparable with those observed in large coiling series. Efficacy data are more difficult to compare with historical series because most are mixed sidewall and bifurcation locations, with both narrow- and wide-neck aneurysms. Third, the potential WEB “compression” phenomenon has not been evaluated in this study, and further work is being conducted on this topic.24,25 Finally, anatomic results were evaluated with heterogeneous imaging techniques (DSA, MRA, and CTA), and MRA has a relatively low sensitivity for aneurysm remnant detection.26

Conclusions

WEBCAST 2 results are in line with WEBCAST and French Observatory results, showing high safety and great efficacy of aneurysm treatment with WEB-SL devices.

Footnotes

  • Disclosures: Laurent Pierot—RELATED: Consulting Fee or Honorarium: Sequent Medical; UNRELATED: Consultancy: Blockade Medical, Medtronic, MicroVention, Neuravi, Penumbra. Jan Hendrik Buhk—UNRELATED: Consultancy: Acandis, Codman Neurovascular, MicroVention, Sequent Medical. Markus Holtmannspötter—UNRELATED: Consultancy: MicroVention, Covidien, Sequent Medical, Mentice, Stryker, Comments: consultancy and proctoring fees; Payment for Lectures Including Service on Speakers Bureaus: MicroVention, Covidien, Sequent Medical; Travel/Accommodations/Meeting Expenses Unrelated to Activities Listed: MicroVention, Covidien, Sequent Medical, Mentice, Stryker. Denis Herbreteau—RELATED: Support for Travel to Meetings for the Study or Other Purposes: Sequent Medical; Other: Sequent, Comments: proctoring; UNRELATED: Payment for Manuscript Preparation: Sequent Medical; Travel/Accommodations/Meeting Expenses Unrelated to Activities Listed: Sequent Medical. Laurent Spelle—UNRELATED: Consultancy: Sequent, Medtronic, Stryker. Joachim Berkefeld—RELATED: Consulting Fee or Honorarium: Sequent Medical; Support for Travel to Meetings for the Study or Other Purposes: Sequent Medical, Comments: invited speaker for user meetings and sponsored symposium; UNRELATED: Board Membership: Acandis, Pforzheim, Germany, Comments: member of the scientific advisory board; Consultancy: Siemens, Erlangen, Germany, Comments: scientific cooperation.* Anne-Christine Januel—UNRELATED: Grant: Association pour le développement de la Neuroradiologie, Comments: for data monitoring*; Travel/Accommodations/Meeting Expenses Unrelated to Activities Listed: Sequent, Comments: fees and accommodation paid for participation in meetings. Andrew Molyneux—RELATED: Grant: Sequent; Consulting Fee or Honorarium: Sequent Medical, Comments: time for consulting to review adverse events*; Fees for Participation in Review Activities such as Data-Monitoring Boards, Statistical Analysis, Endpoint Committees, and the Like: attended the Society of NeuroInterventional Surgery investigator meeting. James V. Byrne—UNRELATED: Employment: Oxford University Hospital National Health Service Trust, Comments: salary as consultant interventional neuroradiologist; Fees for Participation in Review Activities such as Data-Monitoring Boards, Statistical Analysis, Endpoint Committees, and the Like: Nuffield Department of Surgical Sciences, Oxford University, Comments: contracted core laboratory services.* Jens Fiehler—RELATED: Consulting Fee or Honorarium: Sequent Medical; Support for Travel to Meetings for the Study or Other Purposes: Sequent Medical; UNRELATED: Consultancy: MicroVention, Covidien, Stryker, Codman, Medina, Penumbra; Payment for Lectures Including Service on Speakers Bureaus: MicroVention, Covidien, Stryker, Codman, Medina, Penumbra. Istvan Szikora—RELATED: Consulting Fee or Honorarium: Sequent Medical, Comments: clinical trial fee; Support for Travel to Meetings for the Study or Other Purposes: Sequent Medical*; Other: Sequent Medical, Comments: clinical trial fee*; UNRELATED: Consultancy: Stryker, Codman, Medtronic. Xavier Barreau—RELATED: Consulting Fee or Honorarium: Sequent; Support for Travel to Meetings for the Study or Other Purposes: Sequent; UNRELATED: Consultancy: Stryker. *Money paid to the institution.

  • The WEBCAST 2 trial was supported by Sequent Medical.

  • Clinical Trial Registration is provided at http://www.clinicaltrials.gov. The unique identifier is NCT01778322.

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  • Received November 15, 2016.
  • Accepted after revision February 7, 2017.
  • © 2017 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 38 (6)
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L. Pierot, I. Gubucz, J.H. Buhk, M. Holtmannspötter, D. Herbreteau, L. Stockx, L. Spelle, J. Berkefeld, A.-C. Januel, A. Molyneux, J.V. Byrne, J. Fiehler, I. Szikora, X. Barreau
Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study
American Journal of Neuroradiology Jun 2017, 38 (6) 1151-1155; DOI: 10.3174/ajnr.A5178

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Safety and Efficacy of Aneurysm Treatment with the WEB: Results of the WEBCAST 2 Study
L. Pierot, I. Gubucz, J.H. Buhk, M. Holtmannspötter, D. Herbreteau, L. Stockx, L. Spelle, J. Berkefeld, A.-C. Januel, A. Molyneux, J.V. Byrne, J. Fiehler, I. Szikora, X. Barreau
American Journal of Neuroradiology Jun 2017, 38 (6) 1151-1155; DOI: 10.3174/ajnr.A5178
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