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LetterLETTER
Open Access

Chimeric Antigen Receptor T-Cell Neurotoxicity Neuroimaging: More Than Meets the Eye

J. Gust and G.E. Ishak
American Journal of Neuroradiology October 2019, 40 (10) E50-E51; DOI: https://doi.org/10.3174/ajnr.A6184
J. Gust
aSeattle Children's Division of Pediatric Neurology Department of Neurology University of Washington Seattle, Washington
bCenter for Integrative Brain Research Seattle Children's Research Institute Seattle, Washington
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G.E. Ishak
cSeattle Children's Division of Radiology Department of Radiology University of Washington Seattle, Washington
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References

  1. 1.↵
    1. Gust J,
    2. Hay KA,
    3. Hanafi LA, et al
    . Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T Cells. Cancer Discov 2017;7:1404–19 doi:10.1158/2159-8290.CD-17-0698
    Abstract/FREE Full Text
  2. 2.↵
    1. Gust J,
    2. Taraseviciute A,
    3. Turtle CJ
    . Neurotoxicity associated with CD19-targeted CAR-T cell therapies. CNS Drugs 2018;32:1091–101 doi:10.1007/s40263-018-0582-9 pmid:30387077
    CrossRefPubMed
  3. 3.↵
    1. Gust J,
    2. Finney OC,
    3. Li D, et al
    . Glial injury in neurotoxicity after pediatric CD19-directed CAR-T cell therapy. Ann Neurol 2019;86:42–54 doi:10.1002/ana.25502 pmid:31074527
    CrossRefPubMed
  4. 4.↵
    1. Santomasso BD,
    2. Park JH,
    3. Salloum D, et al
    . Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with b-cell acute lymphoblastic leukemia. Cancer Discov 2018;8:958–71 doi:10.1158/2159-8290.CD-17-1319 pmid:29880584
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 40 (10)
American Journal of Neuroradiology
Vol. 40, Issue 10
1 Oct 2019
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Cite this article
J. Gust, G.E. Ishak
Chimeric Antigen Receptor T-Cell Neurotoxicity Neuroimaging: More Than Meets the Eye
American Journal of Neuroradiology Oct 2019, 40 (10) E50-E51; DOI: 10.3174/ajnr.A6184

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Chimeric Antigen Receptor T-Cell Neurotoxicity Neuroimaging: More Than Meets the Eye
J. Gust, G.E. Ishak
American Journal of Neuroradiology Oct 2019, 40 (10) E50-E51; DOI: 10.3174/ajnr.A6184
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  • Neurotoxic complications of chimeric antigen receptor (CAR) T-cell therapy
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy
    Robert C. Sterner, Rosalie M. Sterner
    Frontiers in Immunology 2022 13
  • Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies
    Xiang Zhou, Leo Rasche, K. Martin Kortüm, Sophia Danhof, Michael Hudecek, Hermann Einsele
    Frontiers in Immunology 2020 11
  • A systematic framework for predictive biomarkers in immune effector cell-associated neurotoxicity syndrome
    Omar H. Butt, Alice Y. Zhou, Beau M. Ances, John F. DiPersio, Armin Ghobadi
    Frontiers in Neurology 2023 14
  • Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation
    Susanne H. C. Baumeister, Gopi S. Mohan, Alaa Elhaddad, Leslie Lehmann
    Frontiers in Oncology 2022 12
  • Automated detection of immune effector cell‐associated neurotoxicity syndrome via quantitative EEG
    Christine A. Eckhardt, Haoqi Sun, Preeti Malik, Syed Quadri, Marcos Santana Firme, Daniel K. Jones, Meike van Sleuwen, Aayushee Jain, Ziwei Fan, Jin Jing, Wendong Ge, Husain H. Danish, Caron A. Jacobson, Daniel B. Rubin, Eyal Y. Kimchi, Sydney S. Cash, Matthew J. Frigault, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover
    Annals of Clinical and Translational Neurology 2023 10 10
  • Imaging of pediatric hematopoietic stem cell transplant recipients: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
    Sherwin S. Chan, Ailish Coblentz, Aashim Bhatia, Sue C. Kaste, Joyce Mhlanga, Marguerite T. Parisi, Paul Thacker, Stephan D. Voss, Elizabeth K. Weidman, Marilyn J Siegel
    Pediatric Blood & Cancer 2023 70 S4
  • Neurotoxic complications of chimeric antigen receptor (CAR) T-cell therapy
    Frederick W Vonberg, Imran Malik, Maeve O’Reilly, Harpreet Hyare, Aisling S Carr, Claire Roddie
    Journal of Neurology, Neurosurgery & Psychiatry 2025

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