COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern
Abstract
SUMMARY: Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of “endotheliitis” associated with this novel coronavirus.
ABBREVIATIONS:
- ACE2
- angiotensin converting enzyme 2
- COVID-19
- coronavirus disease 2019
- SARS-CoV-2
- Severe Acute Respiratory Syndrome coronavirus 2
- © 2020 by American Journal of Neuroradiology
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