Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR is seeking candidates for the AJNR Podcast Editor. Read the position description.

Research ArticlePediatrics
Open Access

Arterial Spin-Labeling Perfusion for PHACE Syndrome

M.D. Mamlouk, A. Vossough, L. Caschera, M. Maheshwari and C.P. Hess
American Journal of Neuroradiology January 2021, 42 (1) 173-177; DOI: https://doi.org/10.3174/ajnr.A6871
M.D. Mamlouk
aFrom the Department of Radiology (M.D.M.), The Permanente Medical Group, Kaiser Permanente Medical Center, Santa Clara, Santa Clara, California
bDepartment of Radiology and Biomedical Imaging (M.D.M., C.P.H.), University of California, San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.D. Mamlouk
A. Vossough
cDepartment of Radiology (A.V., L.C.), Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Vossough
L. Caschera
cDepartment of Radiology (A.V., L.C.), Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
dDepartment of Radiology (L.C.), La Fondazione Institute for Research, Hospitalization and Health Care Ca' Granda Ospedale Maggiore di Milano Policlinico, Milan, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Caschera
M. Maheshwari
eDepartment of Radiology (M.M.), Medical College of Wisconsin, Children’s Hospital of Wisconsin, Milwaukee, Wisconsin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Maheshwari
C.P. Hess
bDepartment of Radiology and Biomedical Imaging (M.D.M., C.P.H.), University of California, San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.P. Hess
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Siegel DH,
    2. Tefft KA,
    3. Kelly T, et al
    . Stroke in children with posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities (PHACE) syndrome: a systematic review of the literature. Stroke 2012;43:1672–74 doi:10.1161/STROKEAHA.112.650952 pmid:22442177
    Abstract/FREE Full Text
  2. 2.
    1. Drolet BA,
    2. Dohil M,
    3. Golomb MR, et al
    . Early stroke and cerebral vasculopathy in children with facial hemangiomas and PHACE association. Pediatrics 2006;117:959–64 doi:10.1542/peds.2005-1683 pmid:16510684
    Abstract/FREE Full Text
  3. 3.↵
    1. Hess CP,
    2. Fullerton HJ,
    3. Metry DW, et al
    . Cervical and intracranial arterial anomalies in 70 patients with PHACE syndrome. AJNR Am J Neuroradiol 2010;31:1980–86 doi:10.3174/ajnr.A2206 pmid:20705698
    Abstract/FREE Full Text
  4. 4.
    1. Heyer GL,
    2. Millar WS,
    3. Ghatan S, et al
    . The neurologic aspects of PHACE: case report and review of the literature. Pediatr Neurol 2006;35:419–24 doi:10.1016/j.pediatrneurol.2006.06.021 pmid:17138012
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Jack AS,
    2. Chow MM,
    3. Fiorillo L, et al
    . Bilateral pial synangiosis in a child with PHACE syndrome. J Neurosurg Pediatr 2016;17:70–75 doi:10.3171/2015.5.PEDS1578 pmid:26405843
    CrossRefPubMed
  6. 6.↵
    1. Jernigan S,
    2. Storey A,
    3. Hammer C, et al
    . Moyamoya syndrome and PHACE syndrome: clinical and radiographic characterization of the intracranial arteriopathy and response to surgical revascularization. J Neurosurg Pediatr 2019;23:493–97 doi:10.3171/2018.10.PEDS18582 pmid:30717056
    CrossRefPubMed
  7. 7.↵
    1. Metry DW,
    2. Garzon MC,
    3. Drolet BA, et al
    . PHACE syndrome: current knowledge, future directions. Pediatr Dermatol 2009;26:381–98 doi:10.1111/j.1525-1470.2009.00944.x pmid:19689512
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Haggstrom AN,
    2. Garzon MC,
    3. Baselga E, et al
    . Risk for PHACE syndrome in infants with large facial hemangiomas. Pediatrics 2010;126:e418–26 doi:10.1542/peds.2009-3166 pmid:20643720
    Abstract/FREE Full Text
  9. 9.↵
    1. Garzon MC,
    2. Epstein LG,
    3. Heyer GL, et al
    . PHACE syndrome: consensus-derived diagnosis and care recommendations. J Pediatr 2016;178:24–33.e22 doi:10.1016/j.jpeds.2016.07.054 pmid:27659028
    CrossRefPubMed
  10. 10.↵
    1. Haller S,
    2. Zaharchuk G,
    3. Thomas DL, et al
    . Arterial spin labeling perfusion of the brain: emerging clinical applications. Radiology 2016;281:337–56 doi:10.1148/radiol.2016150789 pmid:27755938
    CrossRefPubMed
  11. 11.↵
    1. Lee S,
    2. Yun TJ,
    3. Yoo RE, et al
    . Monitoring cerebral perfusion changes after revascularization in patients with Moyamoya disease by using arterial spin-labeling MR imaging. Radiology 2018;288:565–72 doi:10.1148/radiol.2018170509 pmid:29714677
    CrossRefPubMed
  12. 12.↵
    1. Mamlouk MD,
    2. Hess CP
    . Arterial spin-labeled perfusion for vascular anomalies in the pediatric head and neck. Clin Imaging 2016;40:1040–46 doi:10.1016/j.clinimag.2016.06.009 pmid:27372212
    CrossRefPubMed
  13. 13.↵
    1. Mamlouk MD,
    2. Nicholson AD,
    3. Cooke DL, et al
    . Tips and tricks to optimize MRI protocols for cutaneous vascular anomalies. Clin Imaging 2017;45:71–80 doi:10.1016/j.clinimag.2017.05.019 pmid:28622551
    CrossRefPubMed
  14. 14.↵
    1. Boulouis G,
    2. Dangouloff-Ros V,
    3. Boccara O, et al
    . Arterial spin-labeling to discriminate pediatric cervicofacial soft-tissue vascular anomalies. AJNR Am J Neuroradiol 2017;38:633–38 doi:10.3174/ajnr.A5065 pmid:28104640
    Abstract/FREE Full Text
  15. 15.↵
    1. Wright JN,
    2. Wycoco V
    . Asymmetric Meckel cave enlargement: a potential marker of PHACES syndrome. AJNR Am J Neuroradiol 2017;38:1223–27 doi:10.3174/ajnr.A5140 pmid:28408631
    Abstract/FREE Full Text
  16. 16.↵
    1. Krowchuk DP,
    2. Frieden IJ,
    3. Mancini AJ, et al
    ; Subcommittee on The Management of Infantile Hemangiomas. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics 2019;143:e20183475 doi:10.1542/peds.2018-3475 pmid:30584062
    Abstract/FREE Full Text
  17. 17.↵
    1. Léaute-Labrèze C,
    2. Boccara O,
    3. Degrugillier-Chopinet C, et al
    . Safety of oral propranolol for the treatment of infantile hemangioma: a systematic review. Pediatrics 2016;138:e20160353 doi:10.1542/peds.2016-0353 pmid:27688361
    Abstract/FREE Full Text
  18. 18.↵
    1. Olsen GM,
    2. Hansen LM,
    3. Stefanko NS, et al
    . Evaluating the safety of oral propranolol therapy in patients with PHACE syndrome. JAMA Dermatol 2020;156:186–90 doi:10.1001/jamadermatol.2019.3839 pmid:31825455
    CrossRefPubMed
  19. 19.↵
    1. Holland KE,
    2. Frieden IJ,
    3. Frommelt PC, et al
    . Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol 2010;146:775–78 doi:10.1001/archdermatol.2010.158 pmid:20644039
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Siegel DH
    . PHACE syndrome: infantile hemangiomas associated with multiple congenital anomalies—clues to the cause. Am J Med Genet C Semin Med Genet 2018;178:407–13 doi:10.1002/ajmg.c.31659 pmid:30580483
    CrossRefPubMed
  21. 21.↵
    1. Mitchell S,
    2. Siegel DH,
    3. Shieh JT, et al
    . Candidate locus analysis for PHACE syndrome. Am J Med Genet A 2012;158a:1363–67 doi:10.1002/ajmg.a.35341 pmid:22544659
    CrossRefPubMed
  22. 22.↵
    1. Mamlouk MD,
    2. Zimmerman B,
    3. Mathes EF, et al
    . Hearing loss in PHACE syndrome: clinical and radiologic findings. Childs Nerv Syst 2018;34:1717–24 doi:10.1007/s00381-018-3822-x pmid:29748705
    CrossRefPubMed
  23. 23.↵
    1. Bolar DS,
    2. Gagoski B,
    3. Orbach DB, et al
    . Comparison of CBF measured with combined velocity-selective arterial spin-labeling and pulsed arterial spin-labeling to blood flow patterns assessed by conventional angiography in pediatric Moyamoya. AJNR Am J Neuroradioly 2019;40:1842–49 doi:10.3174/ajnr.A6262 pmid:31694821
    CrossRefPubMed
  24. 24.↵
    1. Alsop DC,
    2. Detre JA,
    3. Golay X, et al
    . Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 2015;73:102–16 doi:10.1002/mrm.25197 pmid:24715426
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (1)
American Journal of Neuroradiology
Vol. 42, Issue 1
1 Jan 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Arterial Spin-Labeling Perfusion for PHACE Syndrome
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M.D. Mamlouk, A. Vossough, L. Caschera, M. Maheshwari, C.P. Hess
Arterial Spin-Labeling Perfusion for PHACE Syndrome
American Journal of Neuroradiology Jan 2021, 42 (1) 173-177; DOI: 10.3174/ajnr.A6871

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Arterial Spin-Labeling Perfusion for PHACE Syndrome
M.D. Mamlouk, A. Vossough, L. Caschera, M. Maheshwari, C.P. Hess
American Journal of Neuroradiology Jan 2021, 42 (1) 173-177; DOI: 10.3174/ajnr.A6871
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (3)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Facing PHACE Twenty-five Years Later
    Mitchell T. Braun, Erin F. Mathes, Dawn H. Siegel, Christopher P. Hess, Christine K. Fox, Ilona J. Frieden
    Journal of Vascular Anomalies 2021 2 4
  • Arterial Spin Labeling Applications in Neuroimaging
    Kevin Hsu
    Advances in Clinical Radiology 2021 3
  • Imaging of Vascular Anomalies in the Pediatric Musculoskeletal System
    Nadeen Abu Ata, Arthur B. Meyers, Arnold C. Merrow
    Seminars in Roentgenology 2021 56 3

More in this TOC Section

Pediatrics

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Dual-Layer Detector CT for PEDS Image Quality
Show more Pediatrics

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • AJNR Awards
  • ASNR Foundation Special Collection
  • Most Impactful AJNR Articles
  • Photon-Counting CT
  • Spinal CSF Leak Articles (Jan 2020-June 2024)

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire