Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy

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FIGURE.
An 11-year-old child (A and B) with left-lateralized language on tb-fMRI and bilateral language on rs-fMRI. A 14-year-old adolescent (C and D) with bilateral language on tb-fMRI and left-lateralized language on rs-fMRI.

Table 1:

Language task-based fMRI tasks

Language Task	Description (Task and Control Condition)
ADDT	Task: decide whether a sentence is true or false and taps leg if correct. Control: listen to reverse speech and taps leg each time in response to hearing a beep
ACT	Task: decide whether a list of words falls into a previously presented category (eg, animals) and taps leg when target word matches category. Control: listen to reverse speech and taps leg each time in response to hearing a beep
VF	Task: generate words from a series of letters, ie, must generate as many words covertly/silently in head that begin with a particular letter (5 letters presented per task block via MR imaging goggle system). Control: constant right hand tapping during each 30-minute control block
SWG	Task: generate verbs from a series of nouns, ie, must generate as many verbs covertly/silently from each noun presented (5 nouns presented per task block via MR imaging goggle system). Control: constant left hand tapping during each 30-minute control block

Table 2:

Language laterality based on resting-state and task-based fMRI